Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of<i>Glycyrrhiza glabra</i>flavonoid antioxidants

Singh, Paramdeep; Singh, Damanpreet; Goel, Rajesh Kumar

doi:10.3109/13880209.2015.1063673

Cited by 12 publications

(9 citation statements)

References 63 publications

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“… 43 In addition, G glabra reduced nitrogen radicals and enhanced mitochondrial function during cellular metabolism abating the initial production of free radicals. 20 , 44 Because of its ability to lower ROS, G glabra can decrease the total level of oxidative stress, which indirectly impedes cortisol release . Therefore, although G glabra has been shown to increase the release of cortisol, which is an immunosuppressant, and only has weak cortisol modulatory activity, the anti-inflammatory and antioxidant potential of G glabra may hinder cortisol release, lessening the immunosuppressive effect of cortisol.…”

Section: Discussionmentioning

confidence: 99%

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Martin

Reshamwala

Short

2018

Journal of Chiropractic Medicine

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Objective: The purpose of this case report is to describe the treatment of a patient with acute sinusitis using Glycyrrhiza glabra. Clinical Features: A 26-year-old woman presented with acute sinusitis of 10-day duration. Her symptoms included facial pressure and soreness around the frontal and maxillary sinuses, a headache, pharyngitis, a fever, rhinorrhea, nasal congestion with postnasal drip, a productive cough, myalgias, and fatigue. Intervention and Outcome: After administration of 12 to 15 drops of a 2 000-mg tincture of G glabra twice a day, improvements were noted. Resolution of her symptoms occurred after 3 days of treatment. Conclusion: For the treatment of acute sinusitis, G glabra may be a natural therapeutic remedy. (J Chiropr Med 2018;17:268-274)

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Section: Discussionmentioning

confidence: 99%

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Martin

Reshamwala

Short

2018

Journal of Chiropractic Medicine

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“…D. spatulata contain several flavonoids 28 and it has been reported that flavonoids have antioxidant properties 8,29,30 . Therefore it seems that these compounds have some role in the analgesic effect.…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The aim of the present study is to investigate and evaluate analgesic and anti-inflammatory potential of aqueous and methanolic extracts of Drosera spatulata using different models in rats. The aqueous and methanolic extracts of D. spatulata (at the doses of 3, 4, 5, 8 and 10 mg/Kg body weight) investigated for anti-inflammatory and analgesic activities using various experimental models. Analgesic activity was evaluated using formalin induced paw licking models in rats. Antiinflammatory activity was evaluated using measurement of paw edema volume model in rats. Our results showed that both extracts caused a significant (P < 0.05) dose-dependent reduction of inflammation and pains induced by agent used. These results provide support for the use of aqueous and methanolic extracts of Drosera spatulata in relieving inflammatory, pain and insight into the development of new agents for treating inflammatory and pain diseases but further studies are needed to elucidate the mechanism (s) of action and phytochemical constituents of the plant.

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“…The mice were then placed into a cage and behavior was observed. Seizures were scored according to a modified Racine scale (Racine, 1972;Lüttjohann et al, 2009;Singh et al, 2016) with the following scores: 1 -sudden behavioral arrest; 2 -facial jerking; 3 -myoclonic jerks; 4 -clonic seizure, sitting; 5 -clonic, tonic-clonic seizure, lying on belly; 6, clonic, tonic-clonic seizure with loss of posture and wild jumping; with notation of time of onset of each intensity of seizure and tallying of maximal seizure intensity in two-minute bins. Seizure behavior typically subsides by thirty minutes after PTZ administration, so animals were then returned to their home cages.…”

Section: Behavioral Studymentioning

confidence: 99%

Selective Overexpression of Collybistin in Mouse Hippocampal Pyramidal Cells Enhances GABAergic Neurotransmission and Protects against PTZ-Induced Seizures

George

James

Blas

2021

eNeuro

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Collybistin (CB) is a rho guanine exchange factor found at GABAergic and glycinergic postsynapses that interacts with the inhibitory scaffold protein, gephyrin, and induces accumulation of gephyrin and GABA A receptors (GABA A Rs) to the postsynapse. We have previously reported that the isoform without the src homology 3 (SH3) domain, CBSH3-, is particularly active in enhancing the GABAergic postsynapse in both cultured hippocampal neurons as well as in cortical pyramidal neurons after chronic in vivo expression in in utero electroporated (IUE) rats. Deficiency of CB in knockout mice results in absence of gephyrin and gephyrin-dependent GABA A Rs at postsynaptic sites in several brain regions, including hippocampus. In the present study, we have generated an adeno-associated virus (AAV) that expresses CBSH3-in a cre-dependent manner. Using male and female VGLUT1-IRES-cre or VGAT-IRES-cre mice, we explore the effect of overexpression of CBSH3-in hippocampal pyramidal cells or hippocampal interneurons. The results show that: 1) the accumulation of gephyrin and GABA A Rs at inhibitory postsynapses in hippocampal pyramidal neurons or interneurons can be enhanced by CBSH3-overexpression, 2) overexpression of CBSH3-in hippocampal pyramidal cells can enhance the strength of inhibitory neurotransmission, and 3) these enhanced inhibitory synapses provide protection against PTZ-induced seizures. The results indicate that this AAV vector carrying CBSH3-can be used for in vivo enhancement of GABAergic synaptic transmission in selected target neurons in the brain.Significance statement: Excessive or imbalanced excitation in the hippocampus can result in acute or chronic pathological conditions, such as seizures, epilepsy, and learning impairments. It is therefore important to uncover target genes that can be manipulated to restore or prevent this imbalance. This study uses a novel adeno-associated virus to express collybistin SH3-in select cells of the hippocampus. We have found that overexpression of this protein enhances GABAergic inhibitory synaptic transmission. The results also bring attention to collybistin as a possible target for therapeutic intervention aimed to restore the balance between excitation and inhibition.

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Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire ofGlycyrrhiza glabraflavonoid antioxidants

Abstract: From the results, it can be concluded that the flavonoid rich fraction in combination with phenytoin reduces seizure severity and improve cognitive functions in PTZ-kindled mice.

Cited by 12 publications

References 63 publications

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Treatment of a Woman With Glycyrrhiza glabra for Acute Sinusitis: A Case Report

Untitled

Selective Overexpression of Collybistin in Mouse Hippocampal Pyramidal Cells Enhances GABAergic Neurotransmission and Protects against PTZ-Induced Seizures

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