Protective Effects and Mechanisms of Procyanidins on Parkinson’s Disease In Vivo and In Vitro

Cheng, Juan; Chen, Yixuan; Zheng, Yangfan; Zhao, Jiawen; Yu, Huilin; Jin, Zhu; Li, Duo

doi:10.3390/molecules26185558

Cited by 10 publications

(10 citation statements)

References 67 publications

(69 reference statements)

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“…Nuclear factor-erythroid 2-related factor 2 (Nrf2) is released from Keap1 after ROS activation. It will bind to the nucleus's antioxidant response element (ARE), and increased the expression of peroxidase, such as heme oxygenase-1 (HO-1), glutamate-cysteine ligase catalase (GCLC), glutamate-cysteine ligase (GCLM), and quinone oxidoreductase 1 (NQO1) [22]. ACR treatment could also altered the expression of Nrf2 [23].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats

Gao

Xue

et al. 2022

Molecules

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Acrylamide (ACR) is formed during tobacco and carbohydrate-rich food heating and is widely applied in many industries, with a range of toxic effects. The antioxidant properties of Lycium ruthenicum polyphenols (LRP) have been established before. This study aimed to research the protective effect of LRP against ACR-induced liver injury in SD rats. Rats were divided into six groups: Control, ACR (40 mg/kg/day, i.g.), LRP (50, 100, and 200 mg/kg/day, i.g.) plus ACR, and LRP groups. After 19 days, we evaluated oxidative status and mitochondrial functions in the rat’s liver. The results showed that glutathione (GSH) and superoxide dismutase (SOD) levels increased after LRP pretreatment. In contrast, each intervention group reduced reactive oxygen species (ROS) and malondialdehyde (MDA) levels compared to the ACR group. Meanwhile, alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver mitochondrial ATPase activity, mRNA expression of mitochondrial complex I, III, and expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) and its downstream proteins were all increased. This study suggested that LRP could reduce ACR-induced liver injury through potent antioxidant activity. LRP is recommended as oxidative stress reliever against hepatotoxicity.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats

Gao

Xue

et al. 2022

Molecules

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“…The present findings demonstrated that ApoAI MP increased antioxidant properties of PD mouse model by increasing the activities of SOD, CAT and GSH-Px and reducing the content of MDA (Figure 5). During PD, the activities of SOD and the CAT and GSH-Px of the antioxidant defense system are relatively weak, and the improvement of their activities is an important approach in the prevent of PD progression and development (Wang et al, 2018;Chen et al, 2021). Monoamine oxidase promotes the generation of H 2 O 2 , which increases high levels of oxidative stress state and cause injury in PD patients (Youdim, 2018).…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice

Jiang

Bai

2022

Front. Pharmacol.

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Purpose: Parkinson’s disease (PD) is closely associated with oxidative stress and inflammatory situation. Apolipoprotein A-I mimetic peptides (ApoAI MP) have antioxidant and anti-inflammatory properties. We aimed to study the therapeutic effect of ApoAI MP on PD mice, and to explore the related mechanisms.Methods: PD mice were induced by using 1-methyl-4-phenyl-1,2,3,6-tetrathydropyridine (MPTP). The model mice were treated with different concentrations of ApoAI MP. The open-field behavioral test assesses the total distance moved, the rest time, and the number of crossings and Rota-rod was used to evaluate motor coordination. Oxidative stress was identified by measuring the levels of superoxide dismutase (SOD), catalase (CAT), glutathionperoxidase (GSH-Px), malondialdehyde, ROS and H2O2. Inflammatory situation was analyzed by measuring the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Meanwhile, the scavenging activities of ApoAI MP for ABTS, DPPH, hydroxyl radical and superoxide anion, and the effects of the peptide on neurotransmitters were evaluated.Results: PD model establishment increased oxidative stress and inflammatory status by increasing the concentrations of ROS and H2O2 production, and the levels of TNF-α, IL-1β and IL-6 (p < 0.05). ApoAI MP intervention improved PD symptoms by reducing the total moved distance and the number of passes (p < 0.01), and the falling times from Rota-rod, and increasing rest time (p < 0.05). ApoAI MP increased antioxidant properties by increasing the activities of SOD, CAT and GSH-Px, and reducing MDA concentration (p < 0.05). ApoAI MP addition reduced oxidative stress by scavenging ABTS, DPPH, hydroxyl radicals and superoxide anion and reducing the concentrations of ROS and H2O2 production (p < 0.05). ApoAI MP treatment increased anti-inflammatory capacities by reducing the concentrations of TNF-α, IL-1β and IL-6 (p < 0.05). HPLC analysis showed that the peptide treatment improved neurotransmitters.Conclusion: ApoAI MP can improve the behavioral performance of PD mice by improving antioxidant and anti-inflammatory capacities.

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“…The neuroprotective effects of CA are well documented, but these effects are generally attributed to the bioactive triterpenes found in the plant (Xu et al, 2012;Zhang et al, 2012). Though the etiology of PD is not exactly figured out, oxidative stress (Trist et al, 2019) and inflammatory responses (Gao et al, 2022) preventing PD advance and development (Wang et al, 2018;Chen et al, 2021). SOD is a strong endogenous antioxidant enzyme for Superoxide radicals.…”

Section: Pretreatmentmentioning

confidence: 99%

Centella Asiatica Neuroprotective Effect on 6-Ohda-Stimulated Oxidative Stress in Differentiated Sh-Sy5y Cells

YENİ,

ÇİÇEK

2023

SSTB

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Aim: Parkinson's disease is qualified by advancing the loss of dopaminergic neurons and depletion of dopamine. However, the pathophysiological mechanisms need new perspectives for therapeutic strategies that alleviate and abolish neurodegenerative. The last searches have demonstrated that Centella Asiatica is commonly used in conventional medicine. The aim of our study is to reveal the neuroprotective effect of Centella Asiatica, which we will use in the treatment, on the neurotoxicity stimulated by 6 OHDA. Method: First, the SH-SY5Y cell line was grown in prepared media. Then, 25-50-75 and 100 µg/ml concentrations of Centella Asiatica were supplemented to the wells that reached 85% confluence 2 hours before (except for the control and 6-OHDA groups). Afterward, 200 µM 6-OHDA was added to the wells (except for the control group) and incubated for 24 hours. Then, IL-1β, GSH, MTT, LDH, GPx, TNF-α, SOD, MPO, CAT, and MDA analyses were performed. One-way analysis of variance was performed using the IBM SPSS 22.0 package program. The results were compared with the control and 6-OHDA groups, and values below p<.05 were considered statistically significant. Results: It was found that Centella Asiatica demonstrated a dose-dependent rise in the vivacity rate and the cell vivacity was 92% at the highest concentration. Moreover, antioxidant parameters (GSH, GPx, SOD, CAT) correlated with MTT and LDH assay. In IL-1β, TNF-α, MPO, and MDA activities, it was observed that the oxidant amount reduced depending on the concentration. Conclusion: These findings revealed that Centella Asiatica exerts a neuroprotective effect opposite 6-OHDA induction by rising cell viability and reducing oxidative stress.

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Protective Effects and Mechanisms of Procyanidins on Parkinson’s Disease In Vivo and In Vitro

Cited by 10 publications

References 67 publications

Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats

Protective Effect of Lycium ruthenicum Polyphenols on Oxidative Stress against Acrylamide Induced Liver Injury in Rats

Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice

Centella Asiatica Neuroprotective Effect on 6-Ohda-Stimulated Oxidative Stress in Differentiated Sh-Sy5y Cells

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