Protective effects and potential mechanism of salvianolic acid B on sodium laurate-induced thromboangiitis obliterans in rats

Zhang, Ziru; Ji, Jianbo; Zhang, Dawei; Ma, Maoqiang; Sun, Leilei

doi:10.1016/j.phymed.2019.153110

Cited by 29 publications

(17 citation statements)

References 20 publications

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“…The existing research on TAO mainly focuses on in vitro and clinical research. Although animal models of TAO (induced by sodium laurate) have been generated, the establishment and confirmation of these models are only confirmed by pathological examinations (162,163). However, it still has its advantages and limitations in vivo animal models (162,164) (Table 3).…”

Section: Smoking and Animal Models Of Taomentioning

confidence: 99%

Smoking and the Pathophysiology of Peripheral Artery Disease

Wang

Zhao

Geng

et al. 2021

Front. Cardiovasc. Med.

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Smoking is one of the most important preventable factors causing peripheral artery disease (PAD). The purpose of this review is to comprehensively analyze and summarize the pathogenesis and clinical characteristics of smoking in PAD based on existing clinical, in vivo, and in vitro studies. Extensive searches and literature reviews have shown that a large amount of data exists on the pathological process underlying the effects of cigarette smoke and its components on PAD through various mechanisms. Cigarette smoke extracts (CSE) induce endothelial cell dysfunction, smooth muscle cell remodeling and macrophage phenotypic transformation through multiple molecular mechanisms. These pathological changes are the molecular basis for the occurrence and development of peripheral vascular diseases. With few discussions on the topic, we will summarize recent insights into the effect of smoking on regulating PAD through multiple pathways and its possible pathogenic mechanism.

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Section: Smoking and Animal Models Of Taomentioning

confidence: 99%

Smoking and the Pathophysiology of Peripheral Artery Disease

Wang

Zhao

Geng

et al. 2021

Front. Cardiovasc. Med.

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“…Twenty known secondary metabolites were isolated from the antioxidant active fractions: seven phenolic acids (rosmarinic acid (1) [25], chlorogenic acid (2) [26], caffeic acid (3) [25], 4hydroxybenzoic acid (4), benzoic acid (5) [27], salvianolic acid A (8) [28], salvianolic acid B (9) [16]), a flavone (luteolin 7-O-glucoside (6) [29]), one phthalate ester (bis-(2-ethylhexyl)benzene-1,2dicarboxylate ( 7) [24]), five abietane-type diterpenes (7-acetylroyleanone (10) [30], 6,7dehydroroyleanone (11) [31], ferruginol (12) [32], inuroyleanol (13) [33],12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14) [34]), four triterpenes (ursolic acid (15), [24], oleanolic acid (16) [24, taraxasterol (17) [35], lupenone (18) [36]), two steroids (β-sitosterol (19) [24], stigmasterol (20) [37]) (Figure 1). Their structures were elucidated by spectroscopic methods (UV, IR, 1 H-and 13 C-NMR (APT), HMQC, HMBC, Mass).…”

Section: Structure Elucidationmentioning

confidence: 99%

“…Turkish Salvia species have been investigated phytochemically and biologically since 1968; many new and known secondary metabolites were isolated from their roots and aerial parts [6,[10][11][12][13][14][15]. Phytochemical studies on Salvia species indicated the presence of various secondary metabolites belonging mainly to terpenoids, flavonoids, phenolic acids, phenolic glycosides, and other groups [6,[10][11][12][13][14][15][16][17][18][19][20]. While the aerial parts of Salvia species contain especially flavonoid-, terpenoid-and steroid-type secondary metabolites, their roots are rich in diterpenoids.…”

Section: Introductionmentioning

confidence: 99%

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Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

Ertaş¹,

Cakirca²,

Yener³

et al. 2021

Rec.Nat.Prod.

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In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemic species, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and tested for determination of their antioxidant activity using DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity (CUPRAC) test assays. Twenty known secondary metabolites were isolated from the active antioxidant fractions; rosmarinic acid (1), chlorogenic acid (2), caffeic acid (3), 4-hydroxybenzoic acid (4), benzoic acid (5), luteolin 7-O-glucoside (6), bis-(2-ethylhexyl)benzene-1,2-dicarboxylate (7), salvianolic acid A (8), salvianolic acid B (9), 7-acetylroyleanone (10), 6,7-dehydroroyleanone (11), ferruginol (12), inuroyleanol (13), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (14), ursolic acid (15), oleanolic acid (16), taraxasterol (17), lupenone (18), β-sitosterol (19), and stigmasterol (20). Rosmarinic acid, which was obtained from the aerial parts, was found to be the best antioxidant compound among the isolated secondary metabolites in DPPH free radical and ABTS cation radical scavenging, and CUPRAC assays (IC50: 1.20±0.04 µg/mL, IC50: 1.74±0.06 µg/mL, A0.5: 1.22±0.02 µg/mL, respectively). Chlorogenic and caffeic acids, luteolin 7-O-glucoside, salvianolic acids A and B, and inuroyleanol exhibited also high antioxidant activity in the mentioned assays.

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“…The injection was listed in 2004 and is currently included in « Guidelines on the Rational Use of Chinese Drugs in Ischemic Stroke » as a recommended medication for the treatment of cerebral infarction and coronary heart disease. Mechanistic studies showed that DSCXQ could inhibit the production of malondialdehyde (MDA), effectively eliminating oxygen free radicals in rats and increasing the resistance of vascular endothelium to thrombosis (Fei et al, 2017;Zhang et al, 2020). However, previous studies did not fully explore the relevant mechanism of DSCXQ therapy in stroke at the level of metabolites.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Danshen Chuanxiongqin Injection Against Ischemic Stroke: Metabolomic Insights by UHPLC-Q-Orbitrap HRMS Analysis

Zhou

Shi

et al. 2021

Front. Mol. Biosci.

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The incidence of cerebral ischemic stroke characterized by high mortality is increasing every year. Danshen Chuanxiongqin Injection (DSCXQ), a traditional Chinese medicine (TCM) preparation, is often applied to treat cerebral apoplexy and its related sequelae. However, there is a lack of systematic research on how DSCXQ mediates its protective effects against cerebral ischemia stroke. Metabolomic analysis based on UHPLC-Q-Orbitrap HRMS was employed to explore the potential mechanisms of DSCXQ on ischemic stroke induced by transient middle cerebral artery occlusion (MCAO). Pattern analysis and metabolomic profiling, combined by multivariate analysis disclosed that 55 differential metabolites were identified between Sham group and Model group, involving sphingolipid metabolism, glycerophospholipid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, primary bile acid biosynthesis, pantothenate and CoA synthesis and valine, leucine and isoleucine biosynthesis pathways. DSCXQ could reverse brain metabolic deviations in stroke by significantly upregulating the levels of L-tryptophan, Lyso (18:0/0:0), LPC (18:2), Indole-3-methyl acetate, and downregulating the levels of sphinganine 1-phosphate, L-threonic acid, glutaconic acid and N6,N6,N6-Trimethyl-L-lysine. In our study, we focused on the neuroprotective effects of DSCXQ against neuroinflammatory responses and neuronal apoptosis on a stroke model based on sphingolipid metabolism. The expressions of Sphk1, S1PR1, CD62P, Bcl-2, Bax, and cleaved Caspase-3 in brain tissue were evaluated. The neurological deficit, cerebral infarct size and behavioral abnormality were estimated. Results showed that DSCXQ intervention significantly reduced cerebral infarct size, ameliorated behavioral abnormality, inhibited the expression of Sphk1, S1PR1, CD62P, Bax, Cleaved Caspase-3, while increased the level of Bcl-2, and prevented neuronal apoptosis. The limitations are that our study mainly focused on the verification of sphingolipid metabolism pathway in stroke, and while other metabolic pathways left unverified. Our study indicates that SphK1-SIP axis may potentiate neuroinflammatory responses and mediate brain damage through neuronal apoptosis, and DSCXQ could suppress the activity of SphK1-SIP axis to protect brain tissue in cerebral ischemia. In conclusion, this study facilitates our understanding of metabolic changes in ischemia stroke and the underlying mechanisms related to the clinical application of DSCXQ.

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Protective effects and potential mechanism of salvianolic acid B on sodium laurate-induced thromboangiitis obliterans in rats

Cited by 29 publications

References 20 publications

Smoking and the Pathophysiology of Peripheral Artery Disease

Smoking and the Pathophysiology of Peripheral Artery Disease

Bioguided Isolation of Secondary Metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa

Neuroprotective Effects of Danshen Chuanxiongqin Injection Against Ischemic Stroke: Metabolomic Insights by UHPLC-Q-Orbitrap HRMS Analysis

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