Protective effects of 17beta-estradiol on post-ischemic cardiac dysfunction and norepinephrine overflow through the non-genomic estrogen receptor/nitric oxide-mediated pathway in the rat heart

Fukumoto, Taiki; Tawa, Masashi; Yamashita, Naoto; Ohkita, Mamoru; Matsumura, Yasuo

doi:10.1016/j.ejphar.2012.11.042

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…Estrogen was shown to have a role in cardioprotection against I/R injury. Short-term estrogen treatment (15 minutes before ischemia and 5 minutes at the beginning of reperfusion) improved heart function similar to that seen with pacing postconditioning 3, 103 . In addition, these beneficial effects of estrogen were not observed in the presence of a NOS inhibitor, suggesting that nitric oxide production via ER activation plays a key role in this process 103 .…”

Section: Membrane Delimited (Non-genomic) Signalingsupporting

confidence: 52%

“…Short-term estrogen treatment (15 minutes before ischemia and 5 minutes at the beginning of reperfusion) improved heart function similar to that seen with pacing postconditioning 3, 103 . In addition, these beneficial effects of estrogen were not observed in the presence of a NOS inhibitor, suggesting that nitric oxide production via ER activation plays a key role in this process 103 . Also, there are a number of studies showing that estrogen prevents cardiac hypertrophy; in particular through ERβ 4, 104 .…”

Section: Membrane Delimited (Non-genomic) Signalingsupporting

confidence: 52%

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The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System

Menazza

Murphy

2016

Circulation Research

171

118

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Estrogen has important effects on cardiovascular function including regulation of vascular function, blood pressure, endothelial relaxation, the development of hypertrophy and cardioprotection. However, the mechanisms by which estrogen mediates these effects are still poorly understood. As detailed in this review, estrogen can regulate transcription by binding to two nuclear receptors, ERα and ERβ, which differentially regulate gene transcription. ERα and ERβ regulation of gene transcription is further modulated by tissue specific co-activators and co-repressors. Estrogen can bind to ERα and ERβ localized at the plasma membrane as well as GPER to initiate membrane delimited signaling, which enhances kinase signaling pathways that can have acute and long term effects. The kinase signaling pathways can also mediate transcriptional changes, and can synergize with the estrogen receptor to regulate cell function. This review will summarize the beneficial effects of estrogen in protecting the cardiovascular system through ER-dependent mechanisms with an emphasis on the role of the recently described ER-membrane signaling mechanisms.

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Section: Membrane Delimited (Non-genomic) Signalingsupporting

confidence: 52%

Section: Membrane Delimited (Non-genomic) Signalingsupporting

confidence: 52%

The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System

Menazza

Murphy

2016

Circulation Research

171

118

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“…The pathways involved differ with the severity of ischemia. In this stunning model, MPTP was not opened and so it cannot be involved in the cardioprotective effect of Gen. Possible pathways could be PI3K/Akt and its downstream effector eNOS, as described in PC and in the cardioprotection of estradiol via GPER . Nevertheless, the effects of Gen were unaffected by NOS inhibition with L‐NAME in our stunned rat hearts.…”

Section: Discussionmentioning

confidence: 74%

“…Finally, Gen could release nitric oxide, which is part of a cardioprotective mechanism mediated by the estrogenic receptor under estradiol stimulation . In order to evaluate this, the hearts were treated with the selective inhibitor of NO‐synthase L‐NAME before and during perfusion with Gen.…”

Section: Resultsmentioning

confidence: 99%

Sex differences in the mechano‐energetic effects of genistein on stunned rat and guinea pig hearts

Colareda

Ragone

Consolini

2015

Clin Exp Pharma Physio

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Although the phytoestrogen genistein (Gen) is considered protective in cardiovascular diseases, its direct effects on stunned hearts after transient ischemia-reperfusion (I/R) are unknown. This report studied the effects of 20 μmol/L Gen on the mechano-calorimetric behaviour during I/R of rat and guinea pig hearts to evaluate the energetics of Ca(2+) homeostasis. Isolated beating hearts were perfused with control Krebs solution inside a calorimeter with or without perfusion of Gen before a transient period of I/R. Left ventricular pressure development (P) and total heat rate (Ht) were continuously measured. At 37°C, Gen did not change post-ischemic contractile recovery (PICR), but it increased the relaxation rate. However, PICR was reduced in hearts of male rats and guinea pigs at 30°C. Total muscle economy (P/Ht) showed the same behaviour as P at each temperature. Inhibition of phosphatases with orthovanadate during Gen perfusion prevented a decrease in PICR in male rat hearts, suggesting that this effect is due to tyrosine kinase inhibition. Reperfusing ischemic hearts with 10 mmol/L caffeine-36 mmol/L Na(+)-Krebs induced contracture dependent on the sarcoreticular Ca(2+) content. Contracture relaxation depends on mitochondrial Ca(2+) uptake and Gen reduced the relaxation rate. Moreover, Gen prevented the increase in Rhod-2 fluorescence (free [Ca(2+)]m) of rat cardiomyocytes. In guinea pig hearts, Gen maintained ischemic preconditioning, but was reduced by 5-hydroxydecanoate, suggesting the participation of mitochondrial adenosine triphosphate (ATP)-dependent K channels. Results suggest that Gen acts on several mechanisms that regulate myocardial calcium homeostasis and energetics during I/R, which differ in a temperature- and sex-dependent manner.

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“…Natural estrogens include estrone (E 1 ), 17βestradiol (E 2 ) and estriol (E 3 ), and E 2 plays a particularly important role in the gonadal development and uptake of vitellogenin into oocytes (Gustafsson, 2003;Hess, 2003;Heldring et al, 2007;Hara et al, 2016;Liu et al, 2017) via nuclear estrogen receptors (ERs) (Auchus and Fuqua 1994;Fukumoto et al, 2013;Tsai and O'Malley, 1994). There are three reported isoforms of ER, namely ERα, ERβ and ERγ (Sabo-Attwood et al, 2004;Nagler et al, 2012), and only ERα is known to have a high affinity to estrogens in the ovary.…”

Section: Introductionmentioning

confidence: 99%

Immunoreactivity of estrogen receptor alpha in brain and ovary of the short mackerel Rastrelliger brachysoma (Bleeker, 1851)

Senarat

Kettratad

Kangwanrangsan

et al. 2019

APJMBB

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The reproductive physiology concerning the gonadotropin hormone (GTH) and its downstream target estrogen receptor alpha (ERα) is not well understood in the short mackerel Rastrelliger brachysoma, an economically important marine fish in Thailand. In this study, we tested the hypothesis that the expression of both GTH and ERα in the brain and ovary of R. brachysoma was as reported in other fish species. By applying immunohistochemical techniques, we identified the distribution of ERα-immunoreactive (ir) neurons in the brain and ovary of wild female R. brachysoma during the spawning season along with the distribution of GTHs-ir cells in the ovary. The nucleus lateralis tuberis in the diencephalon had a high number of ERα-ir neurons. In the mesencephalon, dense ERα-ir neuronal fibers were mainly found in the mesencephalic cells, stratum opticum, stratum fibrosum et griseum superficiale and stratum album centrale. Both the valvula and corpus cerebelli in the metencephalon contained ERα-ir neurons in granular and Purkinje cell layers as well as the molecular layer. The ERα-ir neurons were also observed in the medulla oblongata. In the ovary, weak ERα and moderate GTHs immunoreactivities were observed in follicular cells of oocytes in early and late vitellogenic stages. This information provides baseline data required to understand not only the activity of estrogen (E2) on the brain but also the regulatory mechanism of the hypothalamo-pituitary-ovarian axis of R. brachysoma.

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Protective effects of 17beta-estradiol on post-ischemic cardiac dysfunction and norepinephrine overflow through the non-genomic estrogen receptor/nitric oxide-mediated pathway in the rat heart

Cited by 13 publications

References 34 publications

The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System

The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System

Sex differences in the mechano‐energetic effects of genistein on stunned rat and guinea pig hearts

Immunoreactivity of estrogen receptor alpha in brain and ovary of the short mackerel Rastrelliger brachysoma (Bleeker, 1851)

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