Protective effects of 4-nerolidylcatechol against genotoxicity induced by cyclophosphamide

Valadares, Marize Campos; Rezende, Kênnia Rocha; Pereira, Enir Raquel Tavares; Sousa, Marília Cordeiro de; Gonçalves, Bruno Bastos; Assis, J.C. de; Kato, Massuo Jorge

doi:10.1016/j.fct.2007.04.016

Cited by 22 publications

(16 citation statements)

References 14 publications

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“…This recorded data was in complete agreement with earlier reports (Datta and Schliermacher, 1969;Rohrborn and Basler, 1977;Machemer and Lorke, 1978;Iarc, 1981;Valadares et al, 2007;Barekati et al, 2008;Tripathi and Jena, 2009). Also, in the present study, the infection of mice with the three different concentrations of rabies virus CVS showed a significant increase in both structural and numerical chromosomal aberrations and in micronuclei as well, while the mitotic activity of mice bone marrow cells were decreased.…”

Section: Discussionsupporting

confidence: 82%

Protective role of interferon against cytotoxcicity induced by rabies virus in mice

Tohamy¹,

Fahmy²,

Dkhil³

et al. 2010

Afr. J. Biotechnol.

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Rabies remains an important public health problem in the world due to uncontrolled enzootic rabies, lack of safe efficient vaccines and poor information on the risk of contracting rabies post animal exposure. The lethality and mutagenic potential of challenge virus standard (CVS) was evaluated in mice. Mice were intracerebrally infected (MIC) with low, medium and high viral LD 50 (MICLD 50 ). Mice were subjected to immunomodulation using interferon (IFNα-2a) pre-infection. The infected groups pretreated with IFN-α 2a showed a higher survival rate than the infected group. Statistically significant increase in structural and numerical chromosomal aberrations and a decreased mitotic activity of mice bone marrow cells was observed post infection. Pretreatment of the infected groups with IFN α-2a showed a marked and significant reduction of these cytogenetic changes. The increased survival rate and reduced cytogenetic changes suggest that protection induced by interferon against rabies virus activity could be, at least partially, attributable to blockage of the replication of CVS strain of rabies virus. It could be concluded that interferon can be used as an immune enhancer to the application of vaccine administration.

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Section: Discussionsupporting

confidence: 82%

Protective role of interferon against cytotoxcicity induced by rabies virus in mice

Tohamy¹,

Fahmy²,

Dkhil³

et al. 2010

Afr. J. Biotechnol.

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“…On the contrary, there was a protective effect against genotoxicity induced by cyclophosphamide. The effect of the isolated 4-nerolidylcatechol (dosis 12.5, 25 and 50 mg/kg/day, orally) was even better (Valadares et al, 2007).…”

Section: -Nerolidylcatecholmentioning

confidence: 98%

Piper umbellatum L.: A comparative cross-cultural analysis of its medicinal uses and an ethnopharmacological evaluation

Roersch

2010

Journal of Ethnopharmacology

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“…Several biological properties has been attributed to this compound, including antioxidant , chemopreventive (Valadares et al 2007), antitumor (Sacoman et al 2008), cytotoxic Mongelli et al 1999), antimalarial ) and antifungal (Rodrigues et al 2012) …”

Section: -Nerolidylcatechol (4-nrc) (1) Is a Phenolic Compound Isolamentioning

confidence: 99%

4-Nerolidylcatechol analogues as promising anticancer agents

Cortez

Ávila

Cunha

et al. 2015

European Journal of Pharmacology

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4-Nerolidylcatechol (1) is an isolated compound from Pothomorphe umbellata L. (Piperaceae) with promising antitumor cells properties. However it presents lability under light and room temperatures. Many efforts have been directed towards discovering anticancer agents endowed with cytotoxic activities. Here, we evaluated cytotoxic effects of 4-NRC analogues (LQFMs 2-6) and the cell death pathways induced by these compounds in multidrug-resistant K562 cells. Compounds (2-6) exhibited cytotoxic activities in a concentration-dependent manner against leukaemic cells, specially the compounds (3) and (5). Additionally, compounds (1), (3) and (5) promoted marked alterations on the cell morphology, including nuclear changes as demonstrated by Hoescht 33342 staining. Moreover, these compounds promoted apoptosis induction in K562 cells by phosphatidylserine exposure, increase of sub-G1 cells and modulation of the caspases-3/7, -8 and -9 activation. In addition, the pancaspase inhibitor z-VAD-fmk partially reduced the apoptosis induced by the compounds (1) and (5)-induced, suggesting caspase-dependent and caspase-independent cell death pathways. Compounds (1) and (5) also modified the cell cycle progression by G0/G1 and S arrest, respectively. Furthermore, compounds (1), (3) and (5) promoted mitochondrial dysfunction associated to accumulation of cytosolic cytochrome c and modulated the NF-ĸB activation. In addition, unlike their analogues, 4-NRC (1) also promoted a significant cyclin D1 inhibition. Together, these data suggest that the mechanism of cell death of 4-NRC and its analogues (3) and (5) occurs by apoptosis through mitochondrial mechanisms. Considering that LQFMs are biocompatible synthetic analogues produced by molecular simplification of (1) without the chiral centre, which is associated with the instability found in compound (1), we suggest that these compounds are promising candidates for further pre-clinical studies.

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Protective effects of 4-nerolidylcatechol against genotoxicity induced by cyclophosphamide

Cited by 22 publications

References 14 publications

Protective role of interferon against cytotoxcicity induced by rabies virus in mice

Protective role of interferon against cytotoxcicity induced by rabies virus in mice

Piper umbellatum L.: A comparative cross-cultural analysis of its medicinal uses and an ethnopharmacological evaluation

4-Nerolidylcatechol analogues as promising anticancer agents

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