Protective effects of a combination of quercetin and vitamin E against cyclosporine A‐induced oxidative stress and hepatotoxicity in rats

Mostafavi‐Pour, Zohreh; Zal, Fatemeh; Monabati, Ahmad; Vessal, Mahmood

doi:10.1111/j.1872-034x.2007.00273.x

Cited by 64 publications

(49 citation statements)

References 28 publications

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“…In the future, Arg and nanoparticle preparations might be frequently used in practice, and previous experiments have shown a decrease in the toxic effects of nano ZnO using Arg (Faddah et al, 2012). In addition, dietary L-Arg has protective effects against oxidative stress and inflammation (Huang et al, 2008;Mostafavi-Pour et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Sizova¹,

Yausheva²,

Kosyan³

et al. 2015

MAS

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We studied the influence of highly dispersed elemental iron preparations on the productivity and metabolism of broiler chicks. Iron nanoparticles were synthesized using high-temperature condensation. No toxicity of the nanoparticles and their agglomerates was observed in an experiment utilizing a genetically engineered luminescent strain of Escherichia coli (K12 TG1). The efficiency of single intramuscular injections in 120 broiler chicks (Smena 7) of preparations containing iron particles with sizes of 80 ± 5 nm (nanoparticles), 923.7 ± 29.6 nm (nanoparticle agglomerates) or 9.8 ± 0.4 nm (microparticles) was compared. The use of these preparations increased the live weight of the chickens. The maximum difference in live weight was observed 4 days after the injection of nanoparticles (9.8%; P ≤ 0.01), 17 days after the injection of agglomerates (4.97%; P ≤ 0.01), and 17 days after the injection of microparticles (8.5%; P ≤ 0.01). Injections with iron preparations were accompanied by increased protein deposition, causing daily weight gain in chickens. This gain was higher by 1.3 -4.3 g when nanoparticles were used, by 0.6 -1.4 g for agglomerates, and by 0.1 -1.4 g for microparticles. The iron preparations promoted an increase in the arginine content of the chicken liver compared with that of control animals. After the use of nanoparticles, the arginine content increase was 2.25% (P ≤ 0.05) within 1 day and 3.78% (P ≤ 0.05) 7 days after injection. The arginine content increased by 2.08% (P ≤ 0.05) 7 days after the use of agglomerates and by 3.86% (P ≤ 0.05) 21 days after the use of microparticles. Thus, similar biological effects were shown for different sizes of elemental iron particles. These effects were enhanced as the particle size decreased, although further investigation is required before the joint use of metal nanoparticles and arginine.

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Section: Resultsmentioning

confidence: 99%

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Sizova¹,

Yausheva²,

Kosyan³

et al. 2015

MAS

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“…Loke et al [55] conducted an eloquent in vitro study demonstrating that free quercetin provides greater protection from oxidative stress than its conjugated metabolites found in the plasma. While quercetin supplementation studies demonfoods, n3-polyunsaturated fatty acids (n3-PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) [59] and the nutrients vitamins C, E and folate [10,60]. In a recent experiment we found that 2-weeks ingestion of a mixed flavonoid-fish oil supplement significantly decreased acute exerciseinduced oxidative stress (20% decrease in plasma F 2 -isoprostanes) and inflammation (50% decrease in C-reactive protein (CRP), 39% decrease in IL-6) compared to quercetin alone or placebo [25].…”

Section: Discussionmentioning

confidence: 99%

Quercetin supplementation does not alter antioxidant status in humans

Shanely

Knab

Nieman

et al. 2009

Free Radical Research

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This study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18-85 years) and body mass index (BMI) (16.7-52.7 kg/ m2) were studied. Subjects were randomized to one of three groups using double-blinded methods: placebo, 500 mg or 1000 mg quer-cetin/day with 125 mg or 250 mg vitamin C/day, respectively. Pre-and post-study fasting blood samples show that plasma quercetin increased in a dose-responsive manner. The pattern of change in plasma F2-isoprostanes, oxidized low density lipoprotein, reduced glutathione, ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) did not differ between supplementation groups or after adjustment for gender, age, BMI and disease status. In summary, quercetin supplementation over 12 weeks in doses of 500 mg or 1000 mg/day significantly increased plasma quercetin levels, but had no influence on several measures of oxidative stress and antioxidant capacity AbstractThis study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18-85 years) and body mass index (BMI) (16.7-52.7 kg/m 2 ) were studied. Subjects were randomized to one of three groups using double-blinded methods: placebo, 500 mg or 1000 mg quercetin/day with 125 mg or 250 mg vitamin C/day, respectively. Pre-and post-study fasting blood samples show that plasma quercetin increased in a dose-responsive manner. The pattern of change in plasma F 2 -isoprostanes, oxidized low density lipoprotein, reduced glutathione, ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) did not differ between supplementation groups or after adjustment for gender, age, BMI and disease status. In summary, quercetin supplementation over 12 weeks in doses of 500 mg or 1000 mg/day significantly increased plasma quercetin levels, but had no influence on several measures of oxidative stress and antioxidant capacity.

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“…In a study performed by Mostafavi-pour et al, no significant change was observed in SOD activity of the liver in hepatotoxic rats, after vitamin E and/or Quercetin administration. 38 However, in their study, there was no significant reduction in SOD levels of hepatotoxic rats compared to HCs. In our study, although there was a significant reduction in kidney SOD of diabetic rats compared to HCs, no statistical increase was observed upon administration of silymarin or milk thistle extract.…”

Section: Prevention Of Diabetic Nephropathy By Milk Thistle Extract Imentioning

confidence: 99%

Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

et al. 2010

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Objectives:To investigate the effect of silymarin and milk thistle extract on the progression of diabetic nephropathy (DN) in rats. Methods: Diabetes was induced with a single intraperitoneal (IP) injection of streptozotocin (STZ) (60 mg/kg). Silymarin (100 mg/kg/d) or the extract (1.2 g/kg/d) was gavaged for 4 weeks. Blood glucose (BS), serum urea (S u ), serum creatinine (S cr ), and 24-h urine protein (Up) were measured and glomerular filtration rate (GFR) was calculated. Concentration of thiobarbituric acid reactive species (TBARS) and activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were evaluated in the renal tissue. Results: Data were expressed as mean ± SEM. Silymarin or the extract had no significant effect on BS, S cr , and GFR. Both milk thistle extract and silymarin, respectively, decreased S u (mg/dL) (87.1 ± 7.78, p < 0.001; 84.5 ± 7.15, p < 0.001), Up (mg) (5.22 ± 1.56, p = 0.014; 5.67 ± 0.86, p = 0.034), and tissue TBARS (nmol/mg protein) (0.67 ± 0.04, p < 0.001; 0.63 ± 0.07, p < 0.001) in diabetic rats, compared to diabetic control (DC) (S u : 131.0 ± 4.55, Up: 8.3 ± 0.84, TBARS: 0.94 ± 0.06). Both the extract and silymarin could increase the activity of CAT (IU/mg protein) (25.5 ± 4.0, p = 0.005; 20 ± 1.8, p = 0.16) and GPx (IU/mg protein) (0.86 ± 0.05, p = 0.005; 0.74 ± 0.04, p = 0.10), respectively, in diabetic rats compared to DC (CAT = 14.4 ± 2.0, GPx = 0.57 ± 0.02). Conclusion: Milk thistle extract, to a lesser extent silymarin, can attenuate DN in rats possibly by increasing kidney CAT and GPx activity and decreasing lipid peroxidation in renal tissue.

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Protective effects of a combination of quercetin and vitamin E against cyclosporine A‐induced oxidative stress and hepatotoxicity in rats

Cited by 64 publications

References 28 publications

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Quercetin supplementation does not alter antioxidant status in humans

Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

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