Protective effects of a cream containing Dead Sea minerals against UVB‐induced stress in human skin

Portugal-Cohen, Meital; Soroka, Yoram; Ma’or, Ze’evi; Oron, Miriam; Zioni, Tamar; Brégégère, François; Neuman, Rami; Kohen, Ron; Milner, Yoram

doi:10.1111/j.1600-0625.2009.00865.x

Cited by 58 publications

(58 citation statements)

References 71 publications

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“…Several studies have shown that skin cell lines cultivated in vitro and treated with different pollutants are characterized by increased production of pro-inflammatory compounds [38][39][40]. HaCaT (cultured human keratinocyte) cells in the presence of particulate matter released increased amounts of transforming growth factor (TNF-α) and interleukins (IL-1α and IL-8), which resulted in the accumulation of the inflammatory cells causing an inflammatory response [39].…”

Section: Induction Of Inflammatory Cascadementioning

confidence: 99%

“…The microscopic images allow one to observe morphological changes in the epidermal and dermal cells or the density and structure of the collagen network, after exposure to pollution [39,51]. Cell viability in response to stress factors can be also estimated by caspase 3 activity, which is a marker for cell apoptosis [38].…”

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

“…Usually the cells are treated with the pollutant mixture, which consists of, e.g., particulate matter, urban dust, and heavy metals or cigarette smoke [39,48,50]. The impact of ozone or UV radiation can also be evaluated [38,39,47]. The impact of pollution on skin cells and the effect of the anti-pollution treatment are assessed by the quantification of specific markers and cell parameters.…”

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

“…The impact of pollution on skin cells and the effect of the anti-pollution treatment are assessed by the quantification of specific markers and cell parameters. The cell viability is often measured by a mitochondrial activity (MTT) assay [38,40], by an evaluation of lactate dehydrogenase (LDH) release, which is an indicator of cell damage [47], or by cell counting using microscopic techniques [39]. The microscopic images allow one to observe morphological changes in the epidermal and dermal cells or the density and structure of the collagen network, after exposure to pollution [39,51].…”

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

“…These cells can be formed in a single layer or as a reconstructed skin model to create a more differentiated and accurate model of human skin characterized inner alia in the presence of the stratum corneum [40]. Some studies use skin fragments obtained from volunteers after treatments such as skin surgeries, followed by assays performed under in vitro conditions [38,51].…”

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

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The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

et al. 2018

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Exposure to pollution can cause oxidative stress, premature ageing, inflammation, and diseases. Since most of us are exposed to pollution, protection is important. This can be achieved through skin protection or through protection with respect to food and food supplements. There is a wide range of products on the market with anti-pollution claims. However, it is important that these claims are thoroughly validated by proper efficacy testing. When skin cells are exposed to pollution factors, changes in a number of skin properties can be observed, such as lipid composition, lipid and protein oxidation, pH, sebum secretion rate, oxidative stress, inflammation markers, and collagen and elastin levels. These can be measured and used as markers to verify anti-pollution claims. In the present review, we summarize some of the most important in vitro and in vivo tests that are used to determine if an ingredient or formulation has anti-pollution efficacy.

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Section: Induction Of Inflammatory Cascadementioning

confidence: 99%

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

Section: In Vitro Efficacy Testingmentioning

confidence: 99%

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The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

et al. 2018

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Herbal Formulations as Denture Cleansers

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Pharmacological Studies in Natural Oral Care

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Cutaneous Nrf2‐Keap1 pathway modulation by environmental factors: The Dead Sea area as a test case

Cohen

Portugal-Cohen

Oron³

et al. 2022

BioFactors

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The skin is constantly exposed to exogenous environmental stressors and has to cope with excessive oxidative stress and tissue damage. However, exposure to moderate environmental stressors may be beneficial for the cutaneous tissue and assist in protecting against oxidative damage via the enhanced activation of the nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1) pathway. Such moderate stressors can be found in various locations around the globe. In this manuscript, we chose to focus on the Dead Sea (DS) area as a test case to study the effect of moderate stressors on the cutaneous tissue because of the unique combinations of moderate stressors in this area. The exceptional location of the DS at an altitude of À438 meters below sea level (the lowest place on earth) is responsible for its rare accumulation of moderate stressors such as high-water salinity, high atmospheric pressure, and unique solar radiation. In this manuscript, we hypothesized that the unique solar radiation in the DS area generates moderate oxidative stress in the skin leading to the induction of intracellular electrophiles, which in turn can activate the protecting Nrf2-Keap1 pathway. We showed that exposure of human skin organ culture from the same donor to solar radiation at the DS resulted in significant activation of the Nrf2-Keap1 pathway, induction of phase II enzymes, and lower apoptotic activity compared to a nearby location at a higher altitude (Jerusalem +700 m). This remarkable effect of activating the Nrf2 protecting pathway and the importance and characteristics of the solar irradiation at the DS is discussed.

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Protective effects of a cream containing Dead Sea minerals against UVB‐induced stress in human skin

Cited by 58 publications

References 71 publications

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution Claims

Herbal Formulations as Denture Cleansers

Cutaneous Nrf2‐Keap1 pathway modulation by environmental factors: The Dead Sea area as a test case

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