Protective Effects of Adenosine on Myocyte Contractility During Cardioplegic Arrest

Updates in theAmericanHeartAssociation guidelines for cardiopulmonary resuscitation and potential applications to veterinary patients

“…Despite most laboratory animals having a laterally compressed thorax, many experimental CPR models are performed delivering compressions in a ventrodorsal manner, contrary to how canine and feline CPR is often performed in clinical practice . In people, adenosine is recommended to treat regular monomorphic tachyarrhythmias, and has been studied in swine models of arrest . However, there is some information to suggest a different adenosine receptor subtype in canine hearts (eg, dogs have predominantly A 2 receptor subtypes in the myocardium rather than A 1 ), which may limit the utility of adenosine for arrhythmias in dogs .…”

“…5,9,29 In people, adenosine is recommended to treat regular monomorphic tachyarrhythmias, 30 and has been studied in swine models of arrest. 31 However, there is some information to suggest a different adenosine receptor subtype in canine hearts (eg, dogs have predominantly A 2 receptor subtypes in the myocardium rather than A 1 ), which may limit the utility of adenosine for arrhythmias in dogs. 32 Canine models have been utilized to study therapeutic hypothermia; however, the target temperatures are more often determined relative to normal human body temperature, rather than taking into account normal canine temperature (ie, 1-2 • C [1.8-3.6 • F]) higher than people).…”