Protective effects of agmatine against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice

El‐Agamy, Dina S.; Makled, Mirhan N.; Gamil, Nareman M.

doi:10.1007/s10787-013-0188-2

Cited by 21 publications

(24 citation statements)

References 40 publications

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“…Agmatine has multiple roles in several biological processes 3435. In the present study, we found several lines of evidence indicating that agmatine can enhance NSC differentiation into neurons by modulating expression of let-7a .…”

Section: Discussionsupporting

confidence: 59%

Suppression of MicroRNAlet-7aExpression by Agmatine Regulates Neural Stem Cell Differentiation

Song

Kim

et al. 2016

Yonsei Med J

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PurposeNeural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiation with roles in regulating genes associated with CNS neurogenesis.Materials and MethodsThis study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression.ResultsOur data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a.ConclusionOur study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.

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Section: Discussionsupporting

confidence: 59%

Suppression of MicroRNAlet-7aExpression by Agmatine Regulates Neural Stem Cell Differentiation

Song

Kim

et al. 2016

Yonsei Med J

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“…It is also known that AGM has hepatoprotective effects that may be related to its ability to suppress oxidative stress, NO synthesis and TNF-α production (El-Agamy et al 2014;Rushaidhi et al 2013). The beneficial effect of AGM could relate to the ability of AGM to inhibit iNOS or to block NMDA receptors and/or voltage-dependent Ca 2+ channels (Yang and Reis 1999).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of agmatine in acute chlorpromazine hepatotoxicity in rats

Dejanović¹,

Stevanović²,

Ninković³

et al. 2014

Acta Vet. Brno

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The present study focused on potentially beneficial effects of agmatine on oxidative stress development in the liver during chlorpromazine treatment in rats. We wanted to examine the role of reactive oxygen species and efficiency of antioxidant protection through the determination of malondylaldehyde and total glutathione concentrations in rat liver homogenate, as well as plasma concentrations of malonylaldehyde and sulfhydryl groups after the treatment. Also, liver tissue sections were examined to follow histological changes. Chlorpromazine was applied intraperitoneally at a single dose of 38.7 mg/kg b.w. The second group was treated with both chlorpromazine (at a single dose of 38.7 mg/kg b.w.) and agmatine (at a single dose of 75 mg/kg b.w.). Agmatine was applied immediately after the chlorpromazine. The control group was treated with 0.9% saline solution in the same manner. Rats were sacrificed by decapitation 24 h after the treatment and biochemical and immunohistochemical examinations were performed. Analysis of data showed that treatment with agmatine significantly attenuated the oxidative stress indicators as evidenced by lowering malonylaldehyde concentrations in the liver and in plasma while not affecting liver concentrations of total glutathione and plasma concentration of sulfhydryl groups. Additionally, histological evaluation revealed the improvement of liver damage in this respect. The presented data indicated that intraperitoneally administered agmatine protects against chlorpromazine-induced liver disease in rats.

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“…The blood and liver tissues were collected 8 h after LPS/GalN challenge for subsequent analysis. The chose of 8 h after LPS/GalN challenge were based on previous study [36]. …”

Section: Methodsmentioning

confidence: 99%

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

et al. 2017

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Andrographolide (ADH), a diterpenoid lactone extracted from Andrographis paniculata, has been found to have anti-inflammatory and anti-oxidative effects. However, its protective effects and mechanisms on liver injury have not been investigated clearly. This study takes an attempt to reveal the protective effects and mechanism of ADH on lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced acute liver injury in mice. The mice liver injury model was induced by LPS (60 mg/kg) and D-GalN (800 mg/kg), and ADH was given 1 h after LPS and D-GalN treatment. Hepatic tissue histology was measured by H&E staining. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were detected by detection kits. The levels of TNF-α and IL-1β were detected by ELISA. Moreover, malondialdehyde (MDA) and reactive oxygen species (ROS) contents were also detected. Meanwhile, the expression of Nrf2, HO-1, and NF-κB were detected by western blot analysis. The results showed that ADH treatment improved liver histology and decreased the levels of ALT, AST, MPO, IL-1β, TNF-α, as well as MDA and ROS levels of hepatic tissues in a dose-dependent manner. ADH also inhibited LPS/D-GalN-induced NF-κB activation. The expression of Nrf2 and HO-1 were increased by treatment of ADH. In conclusion, ADH protected against LPS/D-GalN-induced liver injury by inhibiting NF-κB and activating Nrf2 signaling pathway.

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Protective effects of agmatine against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice

Cited by 21 publications

References 40 publications

Suppression of MicroRNAlet-7aExpression by Agmatine Regulates Neural Stem Cell Differentiation

Suppression of MicroRNAlet-7aExpression by Agmatine Regulates Neural Stem Cell Differentiation

Protective effect of agmatine in acute chlorpromazine hepatotoxicity in rats

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

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