Protective Effects of Aloe Vera on Superovulated Oocytes and Folliculogenesis in Diabetic Mice

Afrough, Mahsa; Majd, Naeem Erfani; Najafzadeh, Hossein

doi:10.17795/zjrms-7939

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Previous research on STZ-induced diabetic models suggests that the size of oocytes in the antral follicle is less than other nondiabetic groups (4). Also, Afrough and colleagues reported that diabetes causes a delay in the arrival of oocyte into metaphase II and decreases oocyte diameter and increases the perivitelline space (25). The results further show that the ratio of the diameter of the nucleus to the ooplasm increases significantly in the metformintreated compared to the STZ-induced diabetic rats.…”

Section: Discussionmentioning

confidence: 87%

The effects of metformin on stereological and ultrastructural features of the ovary in streptozotocin-induced diabetes adult rats: An experimental study

Mehrabianfar

Dehghani²,

Karbalaei

et al. 2020

IJRM

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Background: Diabetes is a chronic disease that can affect almost all of the body organs, including male and female reproductive systems. Objective: This study was designed to investigate the preventive effects of metformin on stereological and ultrastructure characteristics of the ovary in the streptozotocin-induced diabetes adult female rats. Materials and Methods: Seventy adult (8-10 wk) female Sprague-Dawley rats (180-200 gr) were equally divided, as follows: (n = 10/each) control; STZ-induced diabetes (single dose of 65 mg/kg STZ, IP); metformin-treated (50 mg/100 gr of body weight, orally); diabetic-metformin-treated; sham 1, (single dose of sodium citrate); sham 2, (0.5 ml of daily oral distilled water); and sham 3, (sodium citrate + distilled water treated). The body mass index, ovarian weight, blood sugar level, cholesterol, and triglyceride were measured. The stereological and ultrastructural features of ovary were assessed. Results: The blood sugar of induced-diabetic rats was increased (p < 0.01). The BMI (p < 0.01), number of granulosa cells (p = 0.04), primordial, primary and secondary follicles (p = 0.03), total volume of ovary (p < 0.01) and cortex, nucleus diameter ratio to the ooplasm were decreased. The number of atretic follicles in the diabetic and diabetic + metformin-treated rats were increased (p < 0.01). The ultrastructural characteristics of ovary were more damaged in diabetic rats. Conclusion: Diabetes has destructive effects on ovarian follicles and causes follicular atresia. Also, the size of oocytes, numbers of granulosa cells and ooplasmic organelles, which are involved in the folliculogenesis are affected by diabetes and metformin has no preventive effects. Key words: Diabetes, Metformin, Ovary, Tissue.

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Section: Discussionmentioning

confidence: 87%

The effects of metformin on stereological and ultrastructural features of the ovary in streptozotocin-induced diabetes adult rats: An experimental study

Mehrabianfar

Dehghani²,

Karbalaei

et al. 2020

IJRM

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“…Whereas aloe vera improves the follicular development and ovulation in diabetic mice by defending against the damages of oxidative stress. 21 The graafian follicles of experimental group B showed decreased size, vacuolization and atrophy of the oocyte. The current research revealed that the mean diameter of graafian follicle in all groups was statistically significant (p-value = 0.004).…”

Section: Discussionmentioning

confidence: 92%

Effects of Aloe Vera Gel on Monosodium Glutamate Induced Ovarian Toxicity in Rats

Majid

2020

Pak Postgrad Med J.

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Aim and Objective: Monosodium glutamate (MSG) is commonly used as a flavor enhancer. The aim of the study was to evaluate the possible protective effect of aloe vera gel on reproductive toxicity induced by MSG in female albino rats. Study design: Experimental study. Place of study: Anatomy department of Shaikh Zayed Postgraduate Medical Institute, Lahore. Material and Method: 36 female Wistar albino rats were randomly divided into three groups. Group A was the control group, it was given distilled water. The experimental group B was treated with 200 mg/kg b.w of MSG dissolved in 1.5 ml of distilled water, for 14 days by gastric intubation. While the experimental group C was provided with 400 mg/kg b.w of aloe vera gel extract, along with 200 mg/kg body weight of MSG dissolved in 1.5 ml of distilled water by gastric intubation for 14 consecutive days at an interval of 24 hours. The rats were dissected on the 15th day and their ovaries were removed. Light microscopic examination was done to study the histological changes. Results: The ovaries demonstrated deformed secondary and graafian follicles with vacuolization and there was a significant decrease in the diameters of secondary follicles (p value= 0.018) in group B. Histopathological changes induced by MSG in the ovaries were improved by co-administration of aloe vera gel in group C (p value=0.003). Conclusion: Aloe vera gel when consumed with MSG minimizes its harmful effects.

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Protective Effects of Aloe Vera on Superovulated Oocytes and Folliculogenesis in Diabetic Mice

Cited by 2 publications

References 13 publications

The effects of metformin on stereological and ultrastructural features of the ovary in streptozotocin-induced diabetes adult rats: An experimental study

The effects of metformin on stereological and ultrastructural features of the ovary in streptozotocin-induced diabetes adult rats: An experimental study

Effects of Aloe Vera Gel on Monosodium Glutamate Induced Ovarian Toxicity in Rats

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