Protective effects of anthocyanins from bilberry extract in rats exposed to nephrotoxic effects of carbon tetrachloride

Popović, Dejan; Kocić, Gordana; Katić, Vuka; Jović, Zorica; Zarubica, Aleksandra; Veličković, Ljubinka Janković; Nikolić, Valentina; Jović, Andrija; Kundalić, Braca; Rakić, Violeta; Ulrih, Nataša Poklar; Skrt, Mihaela; Sokolović, Dušan; Dinić, Ljubomir; Stojanović, Marko; Milosavljević, Aleksandar; Veličković, Filip; Sokolović, Dušan

doi:10.1016/j.cbi.2019.02.022

Cited by 37 publications

(34 citation statements)

References 49 publications

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“…However, Lut administration leads to an increase in GSH, SOD, and GPx activity when compared to the BPA group. Thus, enhancing the level of the endogenous antioxidant enzyme might be considered as the main mechanism for Lut's protective effects against BPA‐induced renal toxicity .…”

Section: Discussionmentioning

confidence: 99%

Protective role of luteolin against bisphenol A‐induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO‐1 pathway

Sita¹,

Gowthami²,

Srikanth³

et al. 2019

IUBMB Life

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For the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory process. Luteolin (Lut) is a plant flavonoid, a pharmacologically active component normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom; it exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Lut on bisphenol A (BPA)‐induced nephron toxicity in rats. Orally administering Lut (100 and 200 mg/kg) diminished BPA‐induced anomalies in the kidney, blood urea nitrogen, creatinine, and serum uric acid levels. Lut therapy reduced the BPA‐influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. This was coupled with significant improvement in kidney histopathologic features. Lut enhanced the nuclear factor‐like 2 (Nrf2) and heme oxygenase 1 (HO‐1) expression, which showed protection against OS induced by BPA. The current outcomes of the study showed that Lut has a strong reactive oxygen species scavenging property and potentially decreases the lipid peroxidation as well as inhibits DNA damage in renal toxicity induced by BPA. In conclusion, the potential antioxidant effect of Lut may be because of its modulatory effect on the Nrf2/antioxidant response element (ARE)/HO‐1 pathway, which means it protects the kidney from BPA‐induced oxidative injury. © 2019 IUBMB Life, 2019

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Section: Discussionmentioning

confidence: 99%

Protective role of luteolin against bisphenol A‐induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO‐1 pathway

Sita¹,

Gowthami²,

Srikanth³

et al. 2019

IUBMB Life

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“…It was found that pretreatment with the anthocyanin-rich extract resulted in a significant reduction in pro-oxidative (H 2 O 2 , oxidized glutathione, xanthine oxidase) and pro-inflammatory markers (myeloperoxidase, nitric oxide, and TNF-α), and a substantial increase of antioxidant enzyme levels (catalase, SOD, glutathione peroxidase, and S-transferase). Moreover, the anthocyanins significantly reduced the degree of damage to the proximal and distal tubules in the kidney cortex [99].…”

Section: Nephroprotective Effectsmentioning

confidence: 92%

“…Anthocyanins are considered to be a functional food factor and to play an important role in the prevention of kidney diseases. For example, a recent study [99] investigated the effects of anthocyanin-rich bilberry extract (200 mg/kg daily) on the antioxidant status of animals intoxicated with CCl 4 . Rats received the extract orally for 7 days, and on the last day, a single dose of CCl 4 was intraperitoneal (i.p.)…”

Section: Nephroprotective Effectsmentioning

confidence: 99%

Anthocyanins: From the Field to the Antioxidants in the Body

et al. 2020

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Anthocyanins are biologically active water-soluble plant pigments that are responsible for blue, purple, and red colors in various plant parts—especially in fruits and blooms. Anthocyanins have attracted attention as natural food colorants to be used in yogurts, juices, marmalades, and bakery products. Numerous studies have also indicated the beneficial health effects of anthocyanins and their metabolites on human or animal organisms, including free-radical scavenging and antioxidant activity. Thus, our aim was to review the current knowledge about anthocyanin occurrence in plants, their stability during processing, and also the bioavailability and protective effects related to the antioxidant activity of anthocyanins in human and animal brains, hearts, livers, and kidneys.

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“…The protein concentration in the tissue homogenate was determined according to the method previously described by Popović et al [30]. The reaction mixture contained 10 µL of the diluted prostate homogenate and 150 µL of the reagent C (1 mL of 1% CuSO 4 , 1 mL of 2% potassium sodium tartrate, and 98 mL Na 2 CO 3 dissolved in 0.1 M NaOH).…”

Section: Determination Of Protein Concentrationmentioning

confidence: 99%

Xanthine Oxidase/Dehydrogenase Activity as a Source of Oxidative Stress in Prostate Cancer Tissue

et al. 2020

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Prostate cancer (PC) is one of the most frequent malignancies. Better biomarkers are constantly wanted, such as those which can help with the prediction of cancer behavior. What is also needed is a marker which may serve as a possible therapeutic target. Oxidative stress (OS), which is a hallmark of cancer, is included in the pathogenesis and progression of PC. We have conducted the present study to determine whether xanthine oxidase/dehydrogenase activity is the source of OS in prostate tissue. We have also determined the concentration of TBA-reactive substances (TBARS) and advanced oxidation protein products (AOPP), as well as the activity of catalase. Xanthine oxidase (XO) activity is significantly higher (p < 0.001) in tumor tissue when compared to the control healthy tissue. The concentration of TBARS (p < 0.001) and AOPP (p < 0.05) are also higher in tumor tissue. Catalase has raised its activity (p < 0.05) versus the control. There is also a strong correlation between XO activity and prostate-specific antigen (PSA) levels in the serum. These results indicate a significant role of XO activity in OS in prostate carcinogenesis, and it could be a possible theranostic biomarker, which can be important for a better understanding of the disease, its evolution, and prognosis. A promising treatment may be using XO inhibitors such as allopurinol as adjuvant therapy.

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Protective effects of anthocyanins from bilberry extract in rats exposed to nephrotoxic effects of carbon tetrachloride

Cited by 37 publications

References 49 publications

Protective role of luteolin against bisphenol A‐induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO‐1 pathway

Protective role of luteolin against bisphenol A‐induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO‐1 pathway

Anthocyanins: From the Field to the Antioxidants in the Body

Xanthine Oxidase/Dehydrogenase Activity as a Source of Oxidative Stress in Prostate Cancer Tissue

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