Protective effects of antioxidants on striatal dopamine release induced by organophosphorus pesticides

Faro, L.R.F.; Costas-Ferreira, Carmen; Pantoja, A.A.; Durán, R.

doi:10.1016/j.pestbp.2022.105035

Cited by 9 publications

(1 citation statement)

References 33 publications

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“…Moreover, the level of lipid peroxidation in the brain of animals was increased after morphine administration [ 37 ]. Furthermore, morphine can elevate dopamine concentration in the synapse, which is metabolized by monoamine oxidase-B in the human body for catalyzing the production of dihydroxyphenylacetic acid and hydrogen peroxide [ [38] , [39] , [40] ]. Thus, the endogenous hydrogen peroxide decomposition produces several cytotoxic reactive oxygen species like hydroxyl radicals [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats

Ma,

Zou,

Lou

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats

Ma,

Zou,

Lou

et al. 2024

Heliyon

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Evaluation of the potential role of glutamatergic, cholinergic, and nitrergic systems in the dopamine release induced by the pesticide glyphosate in rat striatum

Costas‐Ferreira,

Durán,

Faro

2024

J of Applied Toxicology

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Glyphosate (GLY) is a pesticide that severely alters nigrostriatal dopaminergic neurotransmission, inducing great increases in dopamine release from rat dorsal striatum. This GLY‐induced striatal dopamine overflow occurs through mechanisms not yet fully understood, hence the interest in evaluating the role of other neurotransmitter systems in such effects. So, the main objective of this mechanistic study was to evaluate the possible mediation of the glutamatergic, cholinergic, and nitrergic systems in the GLY‐induced in vivo dopamine release from rat dorsal striatum. The extracellular dopamine levels were measured by cerebral microdialysis and HPLC with electrochemical detection. Intrastriatal administration of GLY (5 mmol/L) significantly increased the dopamine release (1102%). Pretreatment with MK‐801 (50 or 400 μmol/L), a non‐competitive antagonist of NMDA receptors, significantly decreased the effect of GLY (by 70% and 74%, respectively), whereas AP‐5 (400 μmol/L), a competitive antagonist of NMDA receptors, or CNQX (500 μmol/L), an AMPA/kainate receptor antagonist, had no significant effect. Administration of the nitric oxide synthase inhibitors, L‐nitroarginine (L‐NAME, 100 μmol/L) or 7‐nitroindazole (7‐NI, 100 μmol/L), also did not alter the effect of GLY on dopamine release. Finally, pretreatment of the animals with mecamylamine, an antagonist of nicotinic receptors, decreased the effect of GLY on dopamine release by 49%, whereas atropine, a muscarinic antagonist, had no significant effect. These results indicate that GLY‐induced dopamine release largely depends on the activation of NMDA and nicotinic receptors in rat dorsal striatum. Future research is needed to determine the effects of this pesticide at environmentally relevant concentrations.

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L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities

Wang,

Huang,

Wang

et al. 2024

Mol Neurobiol

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Protective effects of antioxidants on striatal dopamine release induced by organophosphorus pesticides

Cited by 9 publications

References 33 publications

20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats

20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats

Evaluation of the potential role of glutamatergic, cholinergic, and nitrergic systems in the dopamine release induced by the pesticide glyphosate in rat striatum

L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities

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