Protective effects of Asparagus officinalis extract against Bisphenol A- induced toxicity in Wistar rats

Poormoosavi, Seyedeh Mahsa; Najafzadehvarzi, Hossein; Behmanesh, Mohammad Amin; Amirgholami, Reza

doi:10.1016/j.toxrep.2018.02.010

Cited by 51 publications

(34 citation statements)

References 38 publications

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“…Asparagus officinalis (ASP) is a perennial vegetable with remarkable anti-fungal, anti-hepatotoxic, cytotoxic, antimutagenic, anti-inflammatory and diuretic properties (6). The roots and buds of ASP are rich in many bioactive phytochemicals including oligosaccharides, steroidal saponins, amino acid derivatives and essential minerals, which has been used for treatment of various chronic inflammation diseases and cancers in Chinese traditional medicine (6)(7)(8). Polysaccharides, steroidal saponins and flavonoids extracted from ASP have been reported as main bioactive constituents that might have anti-tumor properties (9).…”

Section: Introductionmentioning

confidence: 99%

Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer

Kong

Fang

et al. 2021

Front. Oncol.

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Ovarian cancer is one of the leading causes of female cancer death. Emerging evidence suggests that many dietary natural products have anti-tumorigenic activity, including that of asparagus officinalis. The current study aimed to assess the anti-tumorigenic and anti-metastatic effects of asparagus officinalis on serous ovarian cancer cell lines and a transgenic mouse model of high grade serous ovarian cancer. Asparagus officinalis decreased cellular viability, caused cell cycle G1 phase arrest and induced apoptosis in the OVCAR5 and SKOV3 cells. Induction of apoptosis and inhibition of cell proliferation was rescued by the pan-caspase inhibitor, Z-VAD-FMK, implying that its cytotoxic effects were mainly dependent on caspase pathways. Asparagus officinalis increased levels of ROS and decreased mitochondrial membrane potential with corresponding increases in PERK, Bip, Calnexin PDI and ATF4 in both cell lines. Treatment with asparagus officinalis also reduced ability of adhesion and invasion through epithelial–mesenchymal transition and reduction of VEGF expression. The combination of Asparagus officinalis with paclitaxel had synergistic anti-proliferative activity. Furthermore, Asparagus officinalis significantly inhibited tumor growth and reduced serum VEGF in a genetically engineered mouse model of ovarian cancer under obese and lean conditions, accompanied with a decrease in the expression of Ki67, VEGF and phosphorylated S6, and in an increase in phosphorylation of AMPK in the ovarian tumor tissues. Overall, our data provide a pre-clinical rationale for asparagus officinalis in the prevention and treatment of ovarian cancer as a novel natural product.

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Section: Introductionmentioning

confidence: 99%

Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer

Kong

Fang

et al. 2021

Front. Oncol.

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“…In the present study, the serum parameters of kidney function (Cr and BUN) elevated in the iron oxide exposure group; these parameters are considered to be important indicators of kidney damage (27). On the same note, our findings indicated that the serum levels of AST, ALT, ALP, and bilirubin were high in the animals exposed to iron ox-ide since they were sensitive to the liver damage indices due to the cell leakage and loss of the functional integrity of the liver membrane induced by iron intoxication (28).…”

Section: Discussionmentioning

confidence: 75%

Effects of Spirulina platensis on the Improvement of Hepatorenal Toxicity Induced by Iron Oxide in Wistar Rats Using Biochemical and Histological Methods

2019

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Background: Iron is a key element in different aspects of life, with a remarkable role in the formation of cell structures. Iron is a hazardous substance with potential toxicity due to involvement in oxidation-reduction reactions, causing oxidative stress. Objectives: The present study aimed to evaluate the protection induced by Spirulina platensis against the toxicity caused by iron in Wistar rats. Methods: This experimental research was conducted on 32 adult male rats of the Wistar breed (mean weight: 200 ± 20 g). The animals were divided into four groups of control (group one), iron oxide intraperitoneal administration (group two; 15 mg/kg bw/day), oral S. platensis and iron oxide administration (group three; 400 mg/kg bw/day), and daily S. platensis (group four). Treatments continued for 16 days. In addition, serum, renal, and hepatic tissue examinations were carried out. Results: According to the biomechanical tests, liver and kidney biomarkers significantly increased in group two (P ≤ 0.05). On the other hand, total antioxidant capacity and thiol protein reduced, while malondialdehyde increased in this group. According to the results of histopathology in group two, there were congested and dilated portal and central veins, while inflammatory areas were also observed in the liver. In addition, casts and acute tubular necrosis were detected in the urinary tubules in the renal examination. In group three, S. platensis and iron oxide-enhanced anti-oxidative properties, resulting in the treatment of liver and kidney functions and tissues. Conclusions: According to the results, Spirulina platensis can overcome the damaging effects of iron on the hepatorenal system of rats and protects rats' liver and kidneys against iron-induced toxicity.

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“…Asparagaceae family is a nutritious garden vegetable, which is native to most parts of Europe, Africa and Asia consumed throughout the world (Poormoosavi et al, 2018). The consumable shoot of A. officinalis is about 20-35cm in length, which is approximately onehalf to two-thirds of the stem (Zhao et al, 2011) and often used to prepare vegetable dishes, soups and salads (Hafizur et al, 2012).…”

Section: Asparagus Officinalis L (Asparagus) Frommentioning

confidence: 99%

“…The seed extract of this plant also had anti-diabetic (Hafizur et al, 2012) and antifungal (Wang and Ng, 2001) activities. It has been reported root extracts of A. officinalis had beneficial impacts on oogenesis in female rats (Jashni et al, 2016), protective effects against liver and kidney damages (Poormoosavi et al, 2018) and neuroprotective activity in an animal model of neurodegenerative disease (Sakurai et al, 2014). Moreover, A. officinalis juice potentiated cyclophosphamide-induced antimutagenic activities in mice (Xinhui and Jing, 2001).…”

Section: Asparagus Officinalis L (Asparagus) Frommentioning

confidence: 99%

Antioxidant and antinociceptive effects of hydroalcoholic root extract of Asparagus officinalis L.

et al. 2020

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Introduction: Asparagus officinalis L. is a medicinal plant, which contains various natural bioactive phytochemicals with potential different pharmacological activities. The present study was designed to investigate the antioxidant and antinociceptive activities of the hydroalcoholic extract obtained from asparagus roots. Methods: The plant material was extracted using ethanol 70% and preliminary phytochemical analyses were carried out. The in vitro antioxidant effects of the plant extract were evaluated using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals and total reducing ability compared to the butylated hydroxytoluene (BHT) as a standard control. The antinociceptive effects were also assessed using formalin and tail-flick test in male Wistar rats. Results: The plant extract was relatively rich in flavonoids. The IC50 value for DPPH scavenging activity of the extract (1117.65±14.26 μg/ml) was significantly higher than that of BHT (64.35±4.09 μg/ml). The plant extract exerted a significantly lower total reducing ability compared to that of BHT. The extract exhibited a significant antinociceptive effect at the early stage of formalin test in the dose of 500mg/kg intraperitoneally. The results of tail-flick test also demonstrated antinociceptive effects compared to control in a dose-dependent manner. However, these antinociceptive activities were not comparable with morphine as a reference agent. Conclusion: A. officinalis roots extract demonstrated considerable antioxidant and antinociceptive activities and it might be attributed to its flavonoids content.

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Protective effects of Asparagus officinalis extract against Bisphenol A- induced toxicity in Wistar rats

Abstract: Graphical abstract

Cited by 51 publications

References 38 publications

Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer

Asparagus officinalis Exhibits Anti-Tumorigenic and Anti-Metastatic Effects in Ovarian Cancer

Effects of Spirulina platensis on the Improvement of Hepatorenal Toxicity Induced by Iron Oxide in Wistar Rats Using Biochemical and Histological Methods

Antioxidant and antinociceptive effects of hydroalcoholic root extract of Asparagus officinalis L.

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