Protective Effects of Basic Fibroblast Growth Factor in Early Atherosclerosis

Six, Isabelle; Mouquet, Frédéric; Corseaux, Delphine; Bordet, Régis; Letourneau, Thierry; Vallet, B.; Dosquet, Christine; Dupuis, B; Jude, Brigitte; Bertrand, Michel E.; Bauters, Christophe; Belle, Éric Van

doi:10.1080/08977190410001724505

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…FGF-2 increases proliferation and migration of endothelial cells (34) and furthermore, maintains their integrity (15,35), antagonizing endothelial dysfunction. In addition, administration of FGF-2 improves endothelial function, decreasing vascular endothelial adhesion molecule expression and macrophage infiltration early on in the course of experimental atherosclerosis (36).…”

Section: Discussionmentioning

confidence: 99%

Association of FGF-2 Concentrations with Atheroma Progression in Chronic Kidney Disease Patients

Božić

Betriu

Bermúdez-López

et al. 2018

CJASN

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Section: Discussionmentioning

confidence: 99%

Association of FGF-2 Concentrations with Atheroma Progression in Chronic Kidney Disease Patients

Božić

Betriu

Bermúdez-López

et al. 2018

CJASN

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“…The NG2 core protein is also responsible for binding several other types of ligands, including kringle domain proteins 39 , integrins 40 , type VI collagen 40 , MT-MMP-1 41 , and growth factors 42, 43 . For example, the NG2 core protein has been shown to bind FGF-1 42 and PDGF-AA 43 , two growth factors that may affect atherogenesis 44, 45 . As a chondroitin sulfate proteoglycan, NG2 may also bind chemokines, which are also critical for atherogenesis 46, 47 .…”

Section: Discussionmentioning

confidence: 99%

NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells

She

Chang

Pang

et al. 2016

ATVB

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Objectives Obesity and hyperlipidemia are critical risk factors for atherosclerosis. Since ablation of NG2 proteoglycan in mice leads to hyperlipidemia and obesity, we investigated the impact of NG2 ablation on atherosclerosis in ApoE null mice. Approach and Results Immunostaining indicates that NG2 expression in plaque, primarily by synthetic smooth muscle cells, increases during atherogenesis. NG2 ablation unexpectedly results in decreased (30%) plaque development, despite aggravated obesity and hyperlipidemia. Mechanistic studies reveal that NG2-positive plaque synthetic smooth muscle cells in culture can sequester low density lipoprotein to enhance foam-cell formation, processes in which NG2 itself plays direct roles. In agreement with these observations, low density lipoprotein retention and lipid accumulation in the NG2/ApoE knockout aorta is 30% less than that seen in the control aorta. Conclusion These results indicate that synthetic smooth muscle cell-dependent low density lipoprotein retention and foam cell formation outweigh obesity and hyperlipidemia in promoting mouse atherogenesis. Our study sheds new light on the role of synthetic smooth muscle cells during atherogenesis. Blocking plaque NG2 or altering synthetic smooth muscle cells function may be promising therapeutic strategies for atherosclerosis.

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“…The vascular rings were prepared as described previously 19 in adapting the technical to the mouse aorta. The vascular rings were stretched to 1.3 g (previously determined as the optimal point of their length-tension relationship).…”

Section: Vascular Reactivity Analysismentioning

confidence: 99%

Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification

et al. 2009

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Background-Chronic renal failure (CRF) is associated with cardiac dysfunction and increased aortic stiffness. The mechanisms involved are not clearly understood. We examined changes over time in cardiac and aortic function in a murine CRF model. Methods and Results-Eight-week-old mice were randomly assigned to 1 of 4 groups: wild-type non-CRF, wild-type CRF, apolipoprotein E knockout non-CRF, and apolipoprotein E knockout CRF. Echocardiography was performed and blood samples were taken at baseline and after 6 and 10 weeks of CRF. Vascular reactivity and adhesion molecule expression were studied after 6 and 10 weeks of CRF. Left ventricular hypertrophy, altered left ventricular relaxation, and increased aortic stiffness were observed after 6 weeks of CRF and persisted after 10 weeks. The 4 groups of mice did not significantly differ in terms of arterial blood pressure and aortic structure. The degree of vascular calcification and serum total cholesterol concentration were higher in the CRF groups than in the non-CRF groups. These changes, however, could not explain the cardiac and vascular differences seen in the 2 CRF groups. In contrast, alterations in vascular reactivity, the upregulation of adhesion molecule expression, and CRF status were significantly associated with these changes. Conclusions-In a mouse model of CRF, left ventricular hypertrophy, cardiac diastolic dysfunction, and increased aortic stiffness were not related to structural changes in the aorta (including aortic calcification) or high serum cholesterol levels. However, cardiac and aortic abnormalities were associated with the extent of subendothelial dysfunction and the severity of CRF.

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Protective Effects of Basic Fibroblast Growth Factor in Early Atherosclerosis

Abstract: Administration of bFGF is associated with important beneficial structural and functional effects in the early stage of experimental atherosclerosis. These results may help us to understand the role of growth factors in atherosclerosis and to anticipate their effects in human arteries.

Cited by 13 publications

References 27 publications

Association of FGF-2 Concentrations with Atheroma Progression in Chronic Kidney Disease Patients

Association of FGF-2 Concentrations with Atheroma Progression in Chronic Kidney Disease Patients

NG2 Proteoglycan Ablation Reduces Foam Cell Formation and Atherogenesis via Decreased Low-Density Lipoprotein Retention by Synthetic Smooth Muscle Cells

Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification

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