Protective effects of berberine in chronic copper-induced liver and gill injury in freshwater grouper (Acrossocheilus fasciatus)

Wang, Chenyang; Wang, Lei; Yang, Leqi; Gao, Chang; Wang, Bin; Shu, Yilin; Wang, Heng; Yan, Yunzhi

doi:10.1016/j.ecoenv.2023.115672

Cited by 7 publications

(3 citation statements)

References 69 publications

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“…An in vitro study has further confirmed berberine's capability to protect hepatocytes from hypoxia/reoxygenation (H/R)-induced damage [39]. In fish, berberine has been shown to protect against chronic copper-induced liver injury in A. fasciatus, significantly diminishing the serum levels of GPT and GOT [24]. Consistent with these findings, our study revealed a marked elevation in the activities of GPT and GOT in tilapia subjected to an HFD alone, indicative of severe liver injury.…”

Section: Discussionmentioning

confidence: 88%

“…Furthermore, it has been demonstrated that berberine could promote lipid metabolism and enhance antioxidant capacity in Mylopharyngodon piceus [22]. In studies focusing on liver health, berberine has shown its effectiveness by reducing hepatocyte apoptosis induced by an HFD in M. amblycephala [23] and by alleviating chronic liver injury induced by copper exposure in Acrossocheilus fasciatus [24]. These findings highlight the necessity for further investigations into the impact of berberine on liver functions across a broader spectrum of fish species.…”

Section: Introductionmentioning

confidence: 94%

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Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Jia,

Hou,

Zhang

et al. 2024

Antioxidants

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Berberine, a natural alkaloid found abundantly in various medicinal plants, exhibits antioxidative, anti-inflammatory, and lipid metabolism-regulatory properties. Nonetheless, its protective effects and the molecular mechanisms underlying liver injury in fish have not been fully elucidated. The aims of this study were to investigate the antioxidative, anti-inflammatory, and lipid metabolism-regulating effects of berberine against high-fat diet (HFD)-induced liver damage and to clarify the underlying molecular mechanisms. Tilapia were fed diets containing two doses of berberine (50 and 100 mg/kg diet) alongside high fat for 60 days. The results showed that berberine treatments (50 and/or 100 mg/kg) significantly reduced elevated aminotransferases, triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) in the plasma. In the liver, berberine treatments significantly increased the expression of peroxisome proliferator-activated receptor α (pparα) and carnitine palmitoyltransferase 1 (cpt-1) genes, leading to a reduction in lipid accumulation. Meanwhile, berberine treatment suppressed lipid peroxidation formation and enhanced antioxidant capacity. Berberine upregulated the mRNA levels of erythroid 2-related factor 2 (nrf2) and its downstream genes including heme oxygenase 1 (ho-1) and glutathione-S-transferase (gstα). Additionally, berberine attenuated the inflammation by inhibiting the expression of toll-like receptor 2 (tlr2), myeloid differential protein-88 (myd88), relb, and inflammatory cytokines such as interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), and il-8. In summary, this study suggested that berberine offers protection against HFD-induced liver damage in tilapia via regulating lipid metabolism, antioxidant status, and immune response. This protective effect may be attributed to the modulation of the Nrf2, TLR2/MyD88/NF-κB, and PPARα signaling pathways.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 94%

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Jia,

Hou,

Zhang

et al. 2024

Antioxidants

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“…Thus, it has been demonstrated that SM reduced negative effects induced by a sublethal level of deltamethrin in common carp [43] and ameliorated the lesions caused by oxidative stress and hepatotoxicity in common carp exposed to sublethal cadmium chloride toxicity [44] or in African catfish (Clarias gariepinus) subjected to fluoride toxicity [45]. Likewise, BBR has demonstrated protective effects in chronic copper-induced liver and gill injury in freshwater grouper (Acrossocheilus fasciatus), through enhanced antioxidant capacity, reduced inflammation responses, and mitigation of the liver and gill's structure damage [46]. Starting from the premise that both compounds have, in general, detoxifying potential and that some medical studies on mice highlighted the potential of SM [27,47,48] or BBR [49,50] to protect the liver against acetaminophen-induced damage, we directed the current study to evaluate these nutraceuticals in mitigating APAP toxicity in carp.…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity in Cyprinus carpio L.

Grădinariu,

Dediu,

Crețu

et al. 2024

Animals

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Berberine (BBR) and silymarin (SM) are natural compounds extracted from plants known for their antioxidant and chemoprotective effects on the liver. The present study aimed to investigate the beneficial properties of BBR and SM and the association of BBR with SM on liver function using fish as “in vivo” models. Moreover, the study investigated their hepatoprotective role after acetaminophen (APAP) exposure. For this purpose, the fish (N = 360; 118.4 ± 11.09 g) were fed with control or experimental diets for 9 weeks. In the experimental diets, the feed was supplemented with either SM (1 g/kg feed), BBR (100 and 200 mg/kg feed), or a combination of BBR with SM (SM 1 g/kg feed + BBR 100 mg/kg feed and, respectively, SM 1 g/kg feed + BBR 200 mg/kg feed). After the feeding trial, seven fish from each tank were randomly selected and exposed to a single APAP dose. The selected serum biochemical markers, oxidative stress markers, and lysozyme activity were used to evaluate the efficiency of the supplements on carp’s health profile, particularly regarding the hepatopancreas function. Our results showed that the inclusion of SM and BBR (either as a single or in combination) reduced the serum contents of total cholesterol, triglyceride, and alanine transaminase. An increase in the high-density cholesterol was observed after the administration of BBR or BBR in association with SM. Both supplements showed hepatoprotective activity against APAP-induced hepatotoxicity, especially BBR. The ameliorative effects of SM (1 g) in association with BBR (100 mg) were highlighted by the modulation of the nonspecific immune system and oxidative stress alleviation after APAP exposure.

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Combination of herbal extracts regulates growth performance, liver and intestinal morphology, antioxidant capacity, and intestinal microbiota in Acrossocheilus fasciatus

Shen,

Ding,

Wang

et al. 2025

Aquaculture

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Protective effects of berberine in chronic copper-induced liver and gill injury in freshwater grouper (Acrossocheilus fasciatus)

Cited by 7 publications

References 69 publications

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding

The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity in Cyprinus carpio L.

Combination of herbal extracts regulates growth performance, liver and intestinal morphology, antioxidant capacity, and intestinal microbiota in Acrossocheilus fasciatus

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