Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice

Dong, Xuyan; Liu, Bing; Luan, Xiying; Sun, Junyan; Liu, Nana; Qin, Song; Du, Zhimin

doi:10.1007/s00343-015-4312-6

Cited by 10 publications

(3 citation statements)

References 24 publications

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“…In a mouse model of non-alcoholic fatty liver, the levels of mitochondrial ROS and inflammatory cytokines were significantly increased, but ROS in mice treated with PC did not change significantly compared to that in the control, indicating that PC can reduce oxidative stress, inhibit inflammation, and thus treat non-alcoholic fatty liver disease. Xia et al (2016) studied the protective effects of PC on alcoholic fatty liver, and found that PC reduced the serum levels of alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol and low-density lipoprotein, and increased the content of SOD and malondialdehyde (MDA) in the liver, thereby reducing oxidative stress. Ou et al (2010) demonstrated that PC could reduce CCl4-induced liver damage by scavenging ROS and enhancing the activity of SOD and glutathione peroxidase (GSH-Px).…”

Section: Antioxidant Effects In Human and Animal Diseases Atherosclerosismentioning

confidence: 99%

Phycobiliproteins: Molecular structure, production, applications, and prospects

et al. 2019

Biotechnology Advances

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178

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Phycobiliproteins (PBPs) are the main component of light-harvesting complexes in cyanobacteria and red algae. In addition to their important role in photosynthesis, PBPs have many potential applications in foods, cosmetics, medical diagnosis and treatment of diseases. However, basic researches and technological innovations are urgently needed for exploring those potentials, such as structure and function, their biosynthesis as well as downstream purification. For medical use and application, mechanisms underlying their therapeutic effects must be elucidated. Focusing on these issues, this article gives a critical review on the current status on PBPs, including their structures and functions, preparation processes and applications. In addition, key technical challenges and possible solutions are prospected.

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Section: Antioxidant Effects In Human and Animal Diseases Atherosclerosismentioning

confidence: 99%

Phycobiliproteins: Molecular structure, production, applications, and prospects

et al. 2019

Biotechnology Advances

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178

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“…This activity of Se-PC is thought to be able to reduce the release of inflammatory factors in the gut, to inhibit the expression of NF-κB and therefore to activate macrophages. Xia et al [ 159 ], in 2016, fed female KM mice with 30% ethanol to elicit symptoms of alcoholic liver disease and evaluated the preventive impact of PC derived from S. platensis . They revealed that PC decreased the blood levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).…”

Section: Pharmaceutical Potentials Of Phycobiliproteinsmentioning

confidence: 99%

Microalgae: A Promising Source of Bioactive Phycobiliproteins

Tounsi,

Ben Hlima,

Hentati

et al. 2023

Marine Drugs

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Phycobiliproteins are photosynthetic light-harvesting pigments isolated from microalgae with fluorescent, colorimetric and biological properties, making them a potential commodity in the pharmaceutical, cosmetic and food industries. Hence, improving their metabolic yield is of great interest. In this regard, the present review aimed, first, to provide a detailed and thorough overview of the optimization of culture media elements, as well as various physical parameters, to improve the large-scale manufacturing of such bioactive molecules. The second section of the review offers systematic, deep and detailed data about the current main features of phycobiliproteins. In the ultimate section, the health and nutritional claims related to these bioactive pigments, explaining their noticeable potential for biotechnological uses in various fields, are examined.

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“…Xia et al (2016) revealed that the phycocyanin could inhibit alcohol-induced acute liver cell damage eff ectively in dose-dependent manner as demonstrated in mice test.…”

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confidence: 91%