Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties

Yun, Nari; Kang, Jung‐Woo; Lee, Sun-Mee

doi:10.1016/j.jnutbio.2011.06.018

Cited by 213 publications

(146 citation statements)

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“…10) It has been reported that CGA could suppress inflammatory factors and attenuate remodeling of liver ischemic injury in mice. 11) Although they are well documented, their effects on MI have yet to be investigated.…”

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Chlorogenic Acid Attenuates Ventricular Remodeling After Myocardial Infarction in Mice

et al. 2013

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SummaryChlorogenic acid (CGA), which is a key component of coffee, has many biological effects such as anti-inflammation activity. However, the effects of CGA on ventricular remodeling after myocardial ischemia have not been well investigated. To test the hypothesis that CGA can attenuate chronic ventricular remodeling after myocardial ischemia, we orally administered CGA to murine myocardial ischemia models. Seven to nine week-old C57BL/6 mice were used. A myocardial infarction (MI) model was produced by permanent ligation of the left anterior descending coronary artery (LAD) using an 8-0 suture passed under the arteries. These mice were randomly assigned into 4 groups in each experimental model. Some MI mice were supplemented orally with CGA (30 mg/kg/day, MI+CGA group, n = 13) as a CGAtreated MI group, and other MI mice received vehicle (MI+vehicle group, n = 11) as a vehicle-treated MI group. Shamoperated mice without MI also received vehicle (Sham+vehicle group, n = 3) as a sham group, and sham-operated mice without MI received CGA (30 mg/kg/day, Sham+CGA group, n = 8) as a Sham+CGA group. Just before sacrifice on day 14, we measured blood pressure and heart rate and performed echocardiography. We obtained 3 transverse sections per heart for histopathologic examination. There were no differences in body weight, heart rate, or blood pressure among the groups on day 14. The vehicle-treated MI group showed significantly impaired left ventricular contraction compared to the sham-operated group. However, the CGA-treated MI group showed significantly improved ventricular contraction compared to the vehicle-treated MI group. Severe myocardial fibrosis with enhanced macrophage infiltration was observed in the vehicle-treated ischemia group on day 14. CGA attenuated these fibrotic changes with suppressed macrophage infiltration without systemic adverse effects. CGA may effectively suppress chronic ventricular remodeling after myocardial ischemia because it is critically involved in the suppression of macrophage infiltration. (Int Heart J 2013; 54: 176-180) Key words: Myocardial Ischemia, Coffee, Polyphenols, Inflammation, Cytokine T he mortality rate in patients with coronary arterial disease (CAD), including myocardial infarction (MI), is high. 1) Myocardial necrosis and ventricular remodeling after MI lead to arrhythmia, cardiac rupture, and heart failure. These complications often result in death. Many studies have shown that macrophage related inflammatory responses are increased by myocardial necrosis.2,3) These inflammatory responses lead to an increase in fibroblasts and increased collagen synthesis. 4-7)Chlorogenic acid (8-tetrahydroxycyclohexacarboxylic acid, 3-(3,4-dihydroxycinnamate, CGA) is a key component of coffee. 8,9) It is known that CGA has many biological effects, such as anti-inflammation, antioxidation, and antihypertension effects.10) It has been reported that CGA could suppress inflammatory factors and attenuate remodeling of liver ischemic injury in mice.11) Although they are well documented,...

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Chlorogenic Acid Attenuates Ventricular Remodeling After Myocardial Infarction in Mice

et al. 2013

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“…Moreover, we previously reported the protective effects of CGA against experimental inflammatory disorders: CGA inhibited high mobility group box 1 release and toll-like receptor 4 signaling pathways in liver during both septic and ischemic insult, suggesting its potential in immunomodulation Yun et al, 2012). Most recently, CGA was shown to suppress HCl/ethanol-and piroxicam-induced gastric mucosal injury (Shimoyama et al, 2013) while its high absorption capacity to gastric and intestinal cells by oral route is focused (Farah et al, 2008;Stalmach et al, 2010).…”

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confidence: 99%

Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats

Kang¹,

Lee²

2014

Biomol Ther

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.biomolther.orgEsophageal reflux of gastric contents causes esophageal mucosal damage and inflammation. Recent studies show that oxygenderived free radicals mediate mucosal damage in reflux esophagitis (RE). Chlorogenic acid (CGA), an ester of caffeic acid and quinic acid, is one of the most abundant polyphenols in the human diet and possesses anti-inflammatory, antibacterial and antioxidant activities. In this context, we investigated the effects of CGA against experimental RE in rats. RE was produced by ligating the transitional region between the forestomach and the glandular portion and covering the duodenum near the pylorus ring with a small piece of catheter. CGA (10, 30 and 100 mg/kg) and omeprazole (positive control, 10 mg/kg) were administered orally 48 h after the RE operation for 12 days. CGA reduced the severity of esophageal lesions, and this beneficial effect was confirmed by histopathological observations. CGA reduced esophageal lipid peroxidation and increased the reduced glutathione/oxidized glutathione ratio. CGA attenuated increases in the serum level of tumor necrosis factor-α, and expressions of inducible nitric oxide synthase and cyclooxygenase-2 protein. CGA alleviates RE-induced mucosal injury, and this protection is associated with reduced oxidative stress and the anti-inflammatory properties of CGA.

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“…Kidney failure is the development of acute kidney injury (Bonventre & Yang, 2011) AKI incidence is increasing both in developed and developing countries (William et al, 1997;Yun, et al, 2012). In Indonesia, the incidence rate of AKI reached 17% of 15,980 patients undergoing hemodialysis.…”

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confidence: 99%

Chlorogenic Acid Attenuated Inflammatory Response in Kidney Disease with Ischemic Reperfusion Injury

Multazam¹,

Rini²

2017

Proceedings of the Health Science International Conference (HSIC 2017)

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Background: Ischemia reperfusion injury (I/R) at kidney has known as the primary cause of AKI and the most seeing through it. Chlorogenic acid (chlorogenic acid/CGA) is one of the most common polyphenols in the human diet. Chlorogenic acid has an antioxidant effect, antiapoptosis, antiinflammation, antifobrosis. Objective: To investigate the anti-inflammatory effect of chlorogenic acid on the kidneys with I/R injury. Method: Twenty male mice (3 months-old). The animals were divided into 4 groups, Ischemia reperfusion (IR, n = 5), I/R injury given CGA dose 3.5 mg/kg/BW (IRCGA1, n = 5), I/R injury given CGA dose of 7 mg/kg/BW (IRCGA2, n = 5), and I/R injury given

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Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties

Cited by 213 publications

References 49 publications

Chlorogenic Acid Attenuates Ventricular Remodeling After Myocardial Infarction in Mice

Chlorogenic Acid Attenuates Ventricular Remodeling After Myocardial Infarction in Mice

Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats

Chlorogenic Acid Attenuated Inflammatory Response in Kidney Disease with Ischemic Reperfusion Injury

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