Protective effects of chlorogenic acid on the meat quality of oxidatively stressed broilers revealed by integrated metabolomics and antioxidant analysis

Zhang, Kai; Li, Xuemin; Zhao, Jinshan; Wang, Yang; Hao, Xiaoyan; Liu, Kaidong; Liu, Huawei

doi:10.1039/d1fo03622j

Cited by 20 publications

(21 citation statements)

References 48 publications

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“…In the present study, CGA increased the GSH content in the intestines of immune-stressed broiler breeders, in agreement with Shi [ 30 ], who found that CGA significantly increased GSH levels in liver tissue and reduced oxidative stress. Several studies have noted that CGA significantly enhanced antioxidant activity in broilers [ 11 , 12 , 25 , 26 ] and pigs [ 13 , 31 ], which was in agreement with our findings. The antioxidant effects of CGA were potentially attributed to its chemical structure for direct scavenging of free radicals and activation of endogenous antioxidant defenses against radicals [ 32 ].…”

Section: Discussionsupporting

confidence: 93%

“…CGA remarkably downregulated serum corticosterone levels, alleviating the stress response of broiler breeders. Our results are in line with other studies showing that dietary CGA supplementation significantly decreased serum corticosterone concentration in DEX-challenged broilers [ 25 ].…”

Section: Discussionsupporting

confidence: 93%

“…Contrary to our findings, Zhao [ 11 ] reported that adding CGA extracted from E. ulmoides leads to an improved diet and the growth performance of heat-stressed broilers. Broiler chickens fed with CGA had a higher ADG than the dexamethasone-challenged animals [ 25 ]. Dietary CGA reduced F/G and increased the survival rate from Clostridium perfringens type A infection [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Bai

Liu

et al. 2022

Veterinary Sciences

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The study was conducted to evaluate the effects of dietary chlorogenic acid supplementation on the growth performance, antioxidant function, and immune response of broiler breeders exposed to immune stress or high stocking density stress. The test was divided into two stress models. For the immune stress test, 198 birds were distributed into three experimental treatments with six replicates per treatment. The treatments were: (1) saline control (birds injected with saline and fed basal diet), (2) LPS group (birds injected with 0.5 mg LPS/kg body weight and fed basal diet), and (3) CGA + LPS group (birds injected with LPS and fed basal diet supplemented with 1 g/kg CGA. LPS was intraperitoneally injected from day 14, and then daily for 10 days. For the high stocking density stress model, 174 birds were distributed into three experimental treatments with six replicates per treatment. The treatments were: (1) controls (birds fed basal diet and raised at a stocking density of 14 broilers per m2), (2) high-density group (birds fed with basal diet and raised at a stocking density of 22 broilers per m2), and (3) high density + CGA group (birds fed with 1 g/kg CGA and raised at a stocking density of 22 broilers per m2). Results showed that LPS injection and high stocking density significantly decreased the body weight and feed intake of broiler breeders, while CGA supplementation increased feed intake of broiler breeders under LPS injection and high stocking density stress. Moreover, LPS injection and high stocking density increased the concentration of corticosterone in serum, and CGA addition remarkably downregulated serum corticosterone levels. The GSH level decreased with LPS injection and CGA increased the GSH concentration in the intestines of immune-stressed broiler breeders. LPS injection promoted the production of circulating proinflammatory cytokines (serum IL-1β and TNF-α) by 72 h after LPS injection. Dietary supplementation with CGA prevented the increase in serum TNF-α caused by LPS. These results suggest that dietary inclusion of 1 g/kg CGA could increase the feed intake of broiler breeders and alleviate the effects of inflammatory mediator stress and exposure to high stocking density.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Bai

Liu

et al. 2022

Veterinary Sciences

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“…After a 30-min blooming period, the meat color parameters, including lightness ( L* ), redness ( a* ) and yellowness ( b* ) values, were measured at room temperature using a colorimeter (CR-410; standard observer, 2°; illuminant, D65; Konica Minota, Inc., Tokyo, Japan), as described by Zhang et al (2022) . The meat color parameters were immediately measured 3 times at different locations of the medial portion of each sample.…”

Section: Methodsmentioning

confidence: 99%

Low-protein diets supplemented with isoleucine alleviate lipid deposition in broilers through activating 5′ adenosine monophosphate-activated protein kinase and janus kinase 2/signal transducer and activator of transcription 3 signaling pathways

Ma¹,

Zhang²,

Shi³

et al. 2023

Poultry Science

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“…Non-targeted liquid chromatography–mass spectrometry has been used to characterize lipid-related metabolites in the muscle of pigs [ 12 ]. Xiao et al adopted 1 H nuclear magnetic resonance spectroscopy to analyze the metabolic composition of chicken meat [ 13 ]. Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) has been used to investigate the underlying mechanisms responsible for chlorogenic acid-induced improvements in meat quality of broiler breast muscles [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Long-Term Protein Restriction on Meat Quality and Muscle Metabolites of Shaziling Pigs

Zheng

Duan

et al. 2022

Animals

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Background: It has been demonstrated that low-protein diets can improve the meat quality of pork. This study aimed to investigate the effects of long-term protein restriction from piglets to finishing pigs for 24 weeks on meat quality and muscle metabolites of Shaziling pigs. Results: Compared to the control group, reducing dietary protein levels by 20% reduced the L* value (p < 0.05), increased the a* value (p < 0.01), and tended to decrease pressing loss (p = 0.06) of longissimus thoracis muscle (LTM). Furthermore, compared to the control group, the −20% group had significantly lower levels of muscular danazol, N,N-dimethyl-Safingol, and cer(d18:0/14:0) (p < 0.05), all of which were positively associated with the L* value and negatively associated with the a* value (p < 0.05). Therefore, danazol, N,N-dimethyl-Safingol, and cer(d18:0/14:0) might be potential biomarkers for meat color. Conclusions: These results indicated that reducing dietary crude protein by 20% for 24 weeks could improve meat quality and alter muscular metabolites of Shaziling pigs, and the improvement in meat quality might be ascribable to decreased danazol, N,N-dimethyl-Safingol and cer(d18:0/14:0).

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Protective effects of chlorogenic acid on the meat quality of oxidatively stressed broilers revealed by integrated metabolomics and antioxidant analysis

Abstract: Oxidation is a major cause of meat quality deterioration during broiler production, leads to the undesirable meat color, impaired water holding capacity (WHC) and thereby impacting consumer appeal and satisfaction....

Cited by 20 publications

References 48 publications

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Low-protein diets supplemented with isoleucine alleviate lipid deposition in broilers through activating 5′ adenosine monophosphate-activated protein kinase and janus kinase 2/signal transducer and activator of transcription 3 signaling pathways

Effects of Long-Term Protein Restriction on Meat Quality and Muscle Metabolites of Shaziling Pigs

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