2007
DOI: 10.1159/000103265
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Protective Effects of Chronic Lithium Treatment against Spatial Memory Retention Deficits Induced by the Protein Kinase AII Inhibitor H-89 in Rats

Abstract: We have previously shown that infusion of the PKAII inhibitor H-89 in the CA1 area of the hippocampus impaired spatial memory retention. There is some evidence suggesting the neuroprotective effects of chronic lithium administration including its ability to attenuate a deleterious effect of chronic stress on spatial memory in rats. In the present study, we investigated whether chronic administration of lithium can improve memory as well as influence the inhibitory effect of H-89 on spatial memory retention. Ma… Show more

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Cited by 24 publications
(15 citation statements)
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“…In addition, a large number of studies indicate the important roles of protein kinases in memory processing [6,12,[20][21][22]33]. For instance, our previous findings show that the inhibition of PKA can affect spatial memory retention [12,15,21]. Thus, we assume that the spatial memory retention enhancement observed in this study is caused in part by the interaction of Boswellia papyrifera extract and BAs fraction with protein kinase pathways in the brain.…”
Section: Discussionsupporting
confidence: 51%
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“…In addition, a large number of studies indicate the important roles of protein kinases in memory processing [6,12,[20][21][22]33]. For instance, our previous findings show that the inhibition of PKA can affect spatial memory retention [12,15,21]. Thus, we assume that the spatial memory retention enhancement observed in this study is caused in part by the interaction of Boswellia papyrifera extract and BAs fraction with protein kinase pathways in the brain.…”
Section: Discussionsupporting
confidence: 51%
“…Protein phosphorylation is mediated by protein kinases and appears to be necessary as a key regulatory mechanism for the establishment of plasticity and long-term memory [32]. In addition, a large number of studies indicate the important roles of protein kinases in memory processing [6,12,[20][21][22]33]. For instance, our previous findings show that the inhibition of PKA can affect spatial memory retention [12,15,21].…”
Section: Discussionmentioning
confidence: 93%
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“…Interestingly, learning and memory centers of the brain are influenced by lithium, since lithium increases performance in hippocampal-dependent spatial memory tasks [95]. An extensive study using GSK-3β heterozygous knockout mice analyzed behavioral parameters from apomorphine-induced stereotypic behavior to startle response and found no distinct difference in behavior [8].…”
Section: Lithiummentioning
confidence: 99%