Protective effects of chronic resveratrol treatment on vascular inflammatory injury in streptozotocin-induced type 2 diabetic rats: Role of NF-kappa B signaling

Zheng, Xiaoying; Zhu, Shirley; Chang, Shufang; Cao, Yanni; Dong, Jie; Li, Juan; Long, Rodney; Zhou, Yifei

doi:10.1016/j.ejphar.2013.10.034

Cited by 70 publications

(45 citation statements)

References 37 publications

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“…2. Diabetic rats suffered mild weight loss [21], which also appeared in our study, but it was reversed by kaempferol (KPF) (Fig. 2A).…”

Section: Effect Of Kpf On Body Weight Blood Glucose and Serum Insulinmentioning

confidence: 56%

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Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

Luo

Yang

Tang

et al. 2015

International Immunopharmacology

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149

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“…2. Diabetic rats suffered mild weight loss [21], which also appeared in our study, but it was reversed by kaempferol (KPF) (Fig. 2A).…”

Section: Effect Of Kpf On Body Weight Blood Glucose and Serum Insulinmentioning

confidence: 56%

“…Immunoreactive insulin was determined by a specific RIA kit (Beijing North Institute of Biology Technology, Beijing, China). Insulin resistance was evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) index, calculated as follows: FPG (mg/dL) × IRI (μU/mL) / 405 [20,21].…”

Section: Serum Biochemical Assaysmentioning

confidence: 99%

Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

Luo

Yang

Tang

et al. 2015

International Immunopharmacology

Self Cite

149

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“…Thus, inhibiting the activation of NF-jB alleviates renal tubular cell apoptosis and renal fibrosis in obstructed kidneys (Tashiro et al 2003). Furthermore, blocking the nuclear translocation of NF-jB p65 attenuates pro-inflammatory cytokines (TNF-a, IL-1b) and chemokines (MCP-1), which dissolve inflammation (Zheng et al 2013). Baicalein possesses a protective effect in radiationinduced injury by modulating NF-jB-mediated inflammatory response via the MAPKs and Akt pathways.…”

Section: Discussionmentioning

confidence: 96%

Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-κB and MAPK signal pathways

Wang

Zhou

et al. 2015

J Mol Hist

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Baicalein is a natural flavonoid that possesses notable anti-inflammatory effects. In this study, we detected whether baicalein protects against inflammatory response in unilateral ureteral obstruction mice model to ameliorate tubulointerstitial fibrosis. Baicalein treatment significantly attenuated tubulointerstitial fibrosis by markedly reducing fibronectin and collagen-I. The downregulation of alpha-smooth muscle actin and upregulation of E-cadherin indicated that the epithelial-mesenchymal transition process was suppressed. Furthermore, baicalein administration blocked the infiltration of macrophages and lymphocytes, as evidenced by the significantly reduced CD68 and CD3 positive cells. Meanwhile, the mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1β, and monocyte chemotactic protein in baicalein-treated groups was markedly reduced compared with the vehicle-treated group. More importantly, unilateral ureteral obstruction induced the activation of NF-κB and mitogen-activated protein kinase signal pathways to switch on inflammatory response to aggravate kidney fibrosis, but these effects were mitigated by baicalein. These data demonstrate that baicalein could inhibit inflammatory process via inactivation of NF-κB and MAPK signal pathways to execute its anti-fibrotic actions in obstructive kidney disease.

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“…In addition, RSV attenuates the inflammatory response of the vascular wall in T2DM rats with high fat diets, and the effects are associated with down-regulation of the NF-κB signaling pathway [30] . Studies in animal models as well as in humans have revealed that the expression of proinflammatory cytokines such as IL-6 and TGF-α is elevated and sustained by hyper glycemia [31,32] .…”

Section: Discussionmentioning

confidence: 99%

Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling

et al. 2014

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Aim: To investigate the therapeutic effects of resveratrol (RSV) on periodontitis in diabetic mice and to explore the underlying mechanisms in vitro. Methods: Experimental periodontitis was induced in db/db mice by ligature application of porphyromonas gingivalis. The mice were treated with RSV (20 mg/kg, po) daily for 4 weeks. Alveolar bone loss, proinflammatory cytokines and TLR4 expression in the gingival tissue were measured. Cultured gingival epithelial cells (GECs) were used for in vitro studies. The transcriptional activity of TLR4 downstream signaling was analyzed using Western blotting. Results: RSV administration significantly decreased the blood glucose levels, and ameliorated alveolar bone loss in db/db mice with experimental periodontitis. RSV administration also suppressed the high levels of IL-1β, IL-6, IL-8, TNF-α, and TLR4 in gingival tissue of the mice. In the GECs incubated in high glucose medium, TLR4 expression was substantially upregulated, which was partly blocked in the presence of RSV. Lipopolysaccharides markedly increased the expression and secretion of IL-1β, IL-6, IL-8, and TNF-α in the GECs cultured in high glucose medium, which was also partly blocked in the presence of RSV. Furthermore, RSV significantly suppressed the phosphorylation of TLR4 downstream factors NF-κB p65, p38MAPK, and STAT3. Conclusion: RSV exerts protective effects against experimental periodontitis in db/db mice via negative regulation of TLR4 signaling.

show abstract

Protective effects of chronic resveratrol treatment on vascular inflammatory injury in streptozotocin-induced type 2 diabetic rats: Role of NF-kappa B signaling

Cited by 70 publications

References 37 publications

Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats

Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-κB and MAPK signal pathways

Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling

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