Protective Effects Of Curcumin Against Benzopyrene Induced Liver Toxicity In Albino Rats.

Kolade, O. Y.; Oladiji, Temidayo Adenike

doi:10.1088/1755-1315/210/1/012013

Cited by 6 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our histopathological findings, which including nephrotoxic adverse effects of B[a]P, including degeneration, atrophy of glomerular tuft and necrotic lining epithelium and disorganization of the hepatic parenchyma, necrosis, and leucocytic cells infiltration agree with previously published studies [44][45][46] . And can be interpreted by a previously published study who recorded that increasing free radical and ROS production by BaP reinforce tissue damages and considered the central causative factor responsible for pathological finding through membrane lipid peroxidation and DNA mutations 47 .…”

Section: Discussionsupporting

confidence: 92%

Zinc Oxide Nanoparticles Improve Testicular Steroidogenesis Machinery Dysfunction In Benzo [α] Pyrene Challenged Rats

Daoud

Mohamed

Ezzo

et al. 2021

Preprint

View full text Add to dashboard Cite

Although Zinc oxide nanoparticles (ZnO NPs) in low doses have potentially positive effects on reproduction by their antioxidant effects, the defensive role of Zinc nanomaterials against environmental pollutants that affect male reproduction has not been adequately studied. We designed our study to assess the impact of ZnO NPs towards reproductive dysfunction induced by Benzo[α]Pyrene (B[a]P). Forty-eight mature male rats were randomly distributed into six equal groups: G1; negative control, G2&3- positive control I &II (either 10 or 30 mg ZnO NPs / kg BW); G4. (150 mg Bap / kg BW), G 5 & 6 (Co- administrated B[a]P with different concentrations of ZnO NPs). Oxidative stress biomarkers, semiquantitative real-time PCR for steroidogenic enzymes (CY11A1, StAR, and 3β- HSD), testosterone levels and histopathology in the liver, kidney, and testicles were examined for this investigation. B[a] P treated group showed significant deterioration in all reproductive parameters and induced oxidative stress. Co-administration ZnO NPs eased oxidative stress and effectively increased the expression of CY11A1, StAR, and 3β- HSD and improved histopathological changes in the examined organs. Our results using the selected doses and with Nano particle properties confirm that ZnO NPs have an obvious ameliorative effect against B[a] P.

show abstract

Section: Discussionsupporting

confidence: 92%

Zinc Oxide Nanoparticles Improve Testicular Steroidogenesis Machinery Dysfunction In Benzo [α] Pyrene Challenged Rats

Daoud

Mohamed

Ezzo

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The effect of benzopyrene in decreasing the average concentration of total protein in the liver may be caused by damage and inflammation of the liver through its effect on the plasma membrane of hepatocytes. He agrees with (Kolade & Oladiji, 2018) about the toxic effect of benzopyrene on the decrease in the total protein concentration resulting from the effect of benzopyrene on the liver, as it destroys it functionally and structurally.…”

Section: Total Protein In the Liversupporting

confidence: 68%

The protective effect of the alcoholic extract Lactuca serriola on some physiological parameters in the liver in white mice induced with Benzo(a)pyrene

Dawood¹,

Hameed²,

Sayer³

2022

Journal of Pharmaceutical Negative Results

View full text Add to dashboard Cite

This study was conducted to investigate the possibility of using the alcoholic extract Lactuca serriole as a protective agent against the chemical compound benzopyrene that causes cancer. Alkanes are the dominant group in addition to the presence of phenol, alkene and ester, the highest concentration of the compound (1-Heneicosyl formate) (42.579) and the lowest concentration of the compound (1,6-Octadien3-ol, 3,7-dimethyl-, 2- aminobenzoate) by (1.009%), the results showed a significant decrease at the level of probability (P≥ 0.05) in the level of total protein in the liver in the group of animals that were dosed with carcinogenic benzopyrene in comparison with the healthy control group, while the effect on the level of total protein was less than in the group of animals that were dosed with carcinogenic benzopyrene, while the effect on the level of total protein was less than in the healthy control group In the groups that were dosed with alcoholic extract of wild lettuce plant with a concentration of 0.006mg/kg for the first group, 0.003 mg/kg for the second group, and a concentration of 0.0015mg/kg for the third group in conjunction with the benzene and pyrene carcinogen in comparison with the control group. It also showed a significant increase at the level of probability (0.05≥P) in the activity of the transaminase enzymes AST and ALT in the liver in the group of animals that were dosed with the carcinogenic substance benzopyrene compared to the healthy control group, while the effect on the level of enzymes was less in the groups that were dosed with alcoholic extract of wild lettuce plant with a concentration of 0.006mg/kg for the first group and 0.003mg/kg for the second group and 0.0015mg/kg for the third group in conjunction with the carcinogenic benzopyrene and compared with the control group.

show abstract

“…Curcumin, for instance, exhibits a protective effect against B[a]P-induced liver toxicity in rats. Its administration counteracted the toxic effects of B[a]P, restoring the normal histological architecture of the liver tissues [165]. Isoorientin, a bioactive flavonoid, displayed significant antitumor and antioxidant properties, effectively mitigating the stimulatory effect of B[a]P on ROS levels.…”

Section: B[a]p-induced Liver Disease and Flavonoidmentioning

confidence: 99%

Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

Kim,

Jee,

Sung

2024

Antioxidants

View full text Add to dashboard Cite

Benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon primarily formed during incomplete organic matter combustion, undergoes a series of hepatic metabolic reactions once absorbed into the body. B[a]P contributes to liver damage, ranging from molecular DNA damage to the onset and progression of various diseases, including cancer. Specifically, B[a]P induces oxidative stress via reactive oxygen species generation within cells. Consequently, more research has focused on exploring the underlying mechanisms of B[a]P-induced oxidative stress and potential strategies to counter its hepatic toxicity. Flavonoids, natural compounds abundant in plants and renowned for their antioxidant properties, possess the ability to neutralize the adverse effects of free radicals effectively. Although extensive research has investigated the antioxidant effects of flavonoids, limited research has delved into their potential in regulating B[a]P metabolism to alleviate oxidative stress. This review aims to consolidate current knowledge on B[a]P-induced liver oxidative stress and examines the role of flavonoids in mitigating its toxicity.

show abstract

Protective Effects Of Curcumin Against Benzopyrene Induced Liver Toxicity In Albino Rats.

Cited by 6 publications

References 44 publications

Zinc Oxide Nanoparticles Improve Testicular Steroidogenesis Machinery Dysfunction In Benzo [α] Pyrene Challenged Rats

Zinc Oxide Nanoparticles Improve Testicular Steroidogenesis Machinery Dysfunction In Benzo [α] Pyrene Challenged Rats

The protective effect of the alcoholic extract Lactuca serriola on some physiological parameters in the liver in white mice induced with Benzo(a)pyrene

Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

Contact Info

Product

Resources

About