Protective effects of curcumin against thyroid hormone imbalance after gas explosion-induced traumatic brain injury via activation of the hypothalamic-pituitary-thyroid axis in male rats

Dong, Xiushuai; Deng, Lvfei; Yao, Sanqiao; Wu, Weidong; Cao, Jia; Sun, Lei; Bai, Yichun; Li, Haibin; Weng, Xiaogang; Ren, Houcheng; Ren, Wenjie

doi:10.1007/s11356-022-20943-2

Cited by 6 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, CMN exhibited antioxidant and anti-inflammatory effects and restored the normal morphology of the thyroid gland, which had been altered by the action of lithium carbonate [48]. In other studies, it was shown that the administration of CMN to rats after gas explosion-induced traumatic brain injury significantly increased the level of FT3 and FT4 to control values [49]. Interestingly, consumption of turmeric rich in CMN in goiter-prone areas in Pakistan reduces the risk of developing this disease [50].…”

Section: Discussionmentioning

confidence: 90%

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Papież

2023

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry

show abstract

Section: Discussionmentioning

confidence: 90%

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Papież

2023

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Cur: 100 mg/kg/every 2-day, 7 days GE disrupts thyroid function, and Cur modulated TH biosynthesis, conversion, and transport. (Dong et al, 2022) Cold-stressed KM male mice Cur: 12.5-50 mg/kg/day, 8 days…”

Section: Gas Explosion (Ge)-induced Traumatic Brain Injury (Tbi)mentioning

confidence: 99%

“…In rats exposed to gas explosions, Cur treatment restored near-normal thyroid hormone levels and tissue structure, modulating key proteins in the HPT axis. This protection involved modulating thyroid hormone biosynthesis, conversion, and transport, mitigating oxidative stress and inflammatory responses (Dong et al, 2022).…”

Section: The Multifaceted Therapeutic Potential Of Curcumin In Thyroi...mentioning

confidence: 99%

Multifaceted physiological and therapeutical impact of curcumin on hormone‐related endocrine dysfunctions: A comprehensive review

Wang,

Zhang,

Zhou

2024

Phytotherapy Research

View full text Add to dashboard Cite

Over the past five decades, Curcumin (Cur), derived from turmeric (Curcuma longa), has gained considerable attention for its potential therapeutic applications. Synthesizing insights from clinical trials conducted over the last 25 years, this review delves into diseases where Cur has demonstrated promise, offering a nuanced understanding of its pharmacokinetics, safety, and effectiveness. Focusing on specific examples, the impact of Cur on various human diseases is explored. Endocrine glands and associated signaling pathways are highlighted, elucidating how Cur influences cellular signaling. The article underscores molecular mechanisms such as hormone level alteration, receptor interaction, cytokine and adipokine expression inhibition, antioxidant enzyme activity, and modulation of transcription factors. Cur showcases diverse protective mechanisms against inflammation and oxidative damage by suppressing antiapoptotic genes and impeding tumor promotion. This comprehensive overview emphasizes the potential of Cur as a natural agent for countering aging and degenerative diseases, calling for further dedicated research in this realm.

show abstract

Curcumin, inflammation, and neurological disorders: How are they linked?

Garodia¹,

Hegde

Kunnumakkara

et al. 2023

Integrative Medicine Research

View full text Add to dashboard Cite

Protective effects of curcumin against thyroid hormone imbalance after gas explosion-induced traumatic brain injury via activation of the hypothalamic-pituitary-thyroid axis in male rats

Cited by 6 publications

References 55 publications

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Multifaceted physiological and therapeutical impact of curcumin on hormone‐related endocrine dysfunctions: A comprehensive review

Curcumin, inflammation, and neurological disorders: How are they linked?

Contact Info

Product

Resources

About