Protective effects of curcumin against traumatic brain injury

Khayatan, Danial; Razavi, Seyed Mehrad; Arab, Zahra Najafi; Niknejad, Amir Hossein; Nouri, Kiana; Momtaz, Saeideh; Gumpricht, Eric; Jamialahmadi, Tannaz; Abdolghaffari, Amir Hossein; Barreto, George E.; Sahebkar, Amirhossein

doi:10.1016/j.biopha.2022.113621

Cited by 75 publications

(25 citation statements)

References 74 publications

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“…In relation to melatonin, it has been evaluated in clinical assays related to cranial nerve diseases, multiple sclerosis, epilepsy, sleep disorders, spinal cord injuries, migraine, trauma brain injury, dementia, Huntington, Alzheimer and Parkinson Diseases [ 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 ]. Of note, some of these diseases have also been studied in experimental models, evaluating the neuroprotective effect of these compounds mainly by their antioxidant and anti-inflammatory properties [ 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 ]. Moreover, the effects of quercetin, melatonin and curcumin have been explored in obese patients in different studies, but they have not proposed gliosis as an important comorbidity [ 2...…”

Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients. Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation. Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management. Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.

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Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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“…In addition to flavonoid phytochemicals, several nonflavonoid phytochemicals like curcumin and resveratrol, have been revealed to possess proteasome-inhibitory action in multiple cancers. Hitherto, curcuminoids have been shown to be effective in various pathological states [343][344][345][346][347][348][349][350][351][352] including malignancies. [353][354][355][356][357] Nevertheless, despite the long history of research, the therapeutic targets and signaling cascades altered by curcumin are still a mystery.…”

Section: Curcuminmentioning

confidence: 99%

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

et al. 2023

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Regarding the multimechanistic nature of cancers, current chemo‐ or radiotherapies often fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur. Brain malignancies, particularly glioblastomas, are difficult‐to‐treat cancers due to their highly malignant and multidimensional biology. Unfortunately, patients suffering from malignant tumors often experience poor prognoses and short survival periods. Thus far, significant efforts have been conducted to discover novel and more effective modalities. To that end, modulation of the ubiquitin‐proteasome system (UPS) has attracted tremendous interest since it affects the homeostasis of proteins critically engaged in various cell functions, for example, cell metabolism, survival, proliferation, and differentiation. With their safe and multimodal actions, phytochemicals are among the promising therapeutic tools capable of turning the operation of various UPS elements. The present review, along with an updated outline of the role of UPS dysregulation in multiple cancers, provided a detailed discussion on the impact of phytochemicals on the UPS function in malignancies, especially brain tumors.

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“…41 Curcumin has been shown to have antibacterial properties since 1949, 42 and other studies have established its numerous pharmacological effects including anti-inflammatory, anticancer, anti-oxidant, wound-healing, and anti-viral activities, all of which are thought to have therapeutic benefits for a number of human-related ailments. [43][44][45][46][47][48][49][50][51][52][53][54] In vitro, curcumin inhibits many enzymes, including cyclooxygenase and the sarcoplasmic/reticulum calcium pump (SERCA). [55][56][57][58][59][60] The mechanisms of action associated with the use of curcumin in CF patients are depicted in Figure 5.…”

Section: Curcuminmentioning

confidence: 99%

Therapeutic potential of phytochemicals for cystic fibrosis

et al. 2023

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The aim of this review was to review and discuss various phytochemicals that exhibit beneficial effects on mutated membrane channels, and hence, improve transmembrane conductance. These therapeutic phytochemicals may have the potential to decrease mortality and morbidity of CF patients. Four databases were searched using keywords. Relevant studies were identified, and related articles were separated. Google Scholar, as well as gray literature (i.e., information that is not produced by commercial publishers), were also checked for related articles to locate/identify additional studies. The relevant databases were searched a second time to ensure that recent studies were included. In conclusion, while curcumin, genistein, and resveratrol have demonstrated effectiveness in this regard, it should be emphasized that coumarins, quercetin, and other herbal medicines also have beneficial effects on transporter function, transmembrane conductivity, and overall channel activity. Additional in vitro and in vivo studies should be conducted on mutant CFTR to unequivocally define the mechanism by which phytochemicals alter transmembrane channel function/activity, since the results of the studies evaluated in this review have a high degree of heterogenicity and discrepancy. Finally, continued research be undertaken to clearly define the mechanism(s) of action and the therapeutic effects that therapeutic phytochemicals have on the symptoms observed in CF patients in an effort to reduce mortality and morbidity.

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Protective effects of curcumin against traumatic brain injury

Cited by 75 publications

References 74 publications

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors

Therapeutic potential of phytochemicals for cystic fibrosis

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