Protective Effects of Curcumin against Oxidative Damage on Skin Cells In Vitro: Its Implication for Wound Healing

Phan, Toan Thang; See, Patrick; Lee, Seng-Teik; Chan, Ssc

doi:10.1097/00005373-200111000-00017

Cited by 213 publications

(128 citation statements)

References 23 publications

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“…Certain reports have shown that curcumin can quench singlet oxygen and can inhibit the production of H 2 O 2 in an aqueous environment (Phan et al, 2001;Das and Das, 2002). The ameliorated process of such antioxidant and free radical scavenging properties of cAuNps over free curcumin can be due to their interaction patterns of phenolic-OH and by abstraction of H atom from C12 methylene group of curcumin (Balasubramanyam et al, 2003;Hatcher et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

A comparative study on the antioxidant and immunomodulatory properties of curcumin conjugated gold nanospheres and free curcumin

2017

J App Pharm Sci

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Curcumin, a phenolic compound isolated from the rhizomes of the plant Curcuma longa, has been known for decades. Owing to the fact of its hydrophobic nature and rapid metabolization, it has not been used as an effective drug so far. To solve the problem of bioavailability of curcumin, gold nanoparticles (cAuNps) reduced and stabilized with curcumin have been prepared. Afterwards, study for their antioxidant defenses and its effect on oxidative stress has been implemented. Cell cytotoxicity of both cAuNps (2.91677×10 2 -2.91677×10 12 particles ml -1 ) and free curcumin (1mM-128mM) were studied by 3-(4, 5-dimethylazol-2-yl)-2, 5-diphenyltetrazolium bromide) (MTT) assay. From the above studies, it was found that cAuNps could ameliorate the antioxidants defenses and could quench the ROS and RNS generated in the cells more significantly compared to free curcumin. This phenomenon is due to the abstraction of H atoms from phenolic functional groups of curcumin in the nanoconjugate form. Thus, the study proposes a strategy for increasing the bioavailability of curcumin as a therapeutic agent as well as increasing its activity due to the synergistic effect of gold conjugated to it.

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Section: Discussionmentioning

confidence: 99%

A comparative study on the antioxidant and immunomodulatory properties of curcumin conjugated gold nanospheres and free curcumin

2017

J App Pharm Sci

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“…It exhibits strong antioxidant, anti-inflammatory, and antimicrobial properties that make it a great candidate for wound healing applications. [8][9][10][11] Besides these properties, it is also attractive for its availability, stability, low cost, and safety, which was demonstrated in numerous clinical trials. The effect of curcumin depends mainly on the dose to which cells are exposed.…”

Section: Introductionmentioning

confidence: 99%

Investigating the use of curcumin-loaded electrospun filaments for soft tissue repair applications

Mouthuy¹,

Škoc²,

Gašparović³

et al. 2017

IJN

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Electrospun filaments represent a new generation of medical textiles with promising applications in soft tissue repair. A potential strategy to improve their design is to combine them with bioactive molecules. Curcumin, a natural compound found in turmeric, is particularly attractive for its antioxidant, anti-inflammatory, and antimicrobial properties. However, investigating the range of relevant doses of curcumin in materials designed for tissue regeneration has remained limited. In this paper, a wide range of curcumin concentrations was explored and the potential of the resulting materials for soft tissue repair applications was assessed. Polydioxanone (PDO) filaments were prepared with various amounts of curcumin: 0%, 0.001%, 0.01%, 0.1%, 1%, and 10% (weight to weight ratio). The results from the present study showed that, at low doses (≤0.1%), the addition of curcumin has no influence on the spinning process or on the physicochemical properties of the filaments, whereas higher doses lead to smaller fiber diameters and improved mechanical properties. Moreover, filaments with 0.001% and 0.01% curcumin stimulate the metabolic activity and proliferation of normal human dermal fibroblasts (NHDFs) compared with the no-filament control. However, this stimulation is not significant when compared to the control filaments (0%). Highly dosed filaments induce either the inhibition of proliferation (with 1%) or cell apoptosis (with 10%) as a result of the concentrations of curcumin found in the medium (9 and 32 μM, respectively), which are near or above the known toxicity threshold of curcumin (~10 μM). Moreover, filaments with 10% curcumin increase the catalase activity and glutathione content in NHDFs, indicating an increased production of reactive oxygen species resulting from the large concentration of curcumin. Overall, this study suggested that PDO electrospun filaments loaded with low amounts of curcumin are more promising compared with higher concentrations for stimulating tissue repair. This study also highlighted the need to explore lower concentrations when using polymers as PDO, such as those with polycaprolactone and other degradable polyesters.

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“…Likewise, it also increases the synthesis of hexosamine, collagen, nitrite, DNA, and histologic determination of wound biopsy specimens that improves the collagen deposition and also enhances in fibroblast ( Jagetia & Rajanikant 2005). Phan et al (2001) determined that the oral dose of curcumin (2.5 µg/ml) showed the significant protective effect against H 2 O 2 to human dermal fibroblasts. Lee (2006) reported that curcumin has an inhibitory effect on platelet aggregation induced by collagen and arachidonic acid.…”

Section: Curcumin Enhanced Wound Healingmentioning

confidence: 97%

Curcumin and its allied analogues: epigenetic and health perspectives - a review

Imran¹,

Nadeem²,

Khan³

et al. 2017

Czech J. Food Sci.

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Curcumin (diferuoyl methane) is a yellow active ingredient present in turmeric. It is a homodimer of feruloylmethane that comprises a hydroxyl and methoxy group (heptadiene with two Michael acceptors), and α-, β-diketone. It contains various metabolites, i.e. hexahydrocurcumin (HHC), tetrahydrocurcumin (THC), octahydrocurcumin (OHC), dihydrocurcumin (DHC), curcumin sulphate, and curcumin glucuronide. Curcumin has been proven the most effective histone deacetylase (HDAC) inhibitor in HeLa nuclear extracts. It has the ability to affect the Akt, growth factors, NF-kB, and metastatic and angiogenic pathways. Curcumin has a strong therapeutic or preventive potential against several major human ailments, i.e. suppression of inflammation, cardiovascular, diabetes, tumorigenesis, chronic fatigue, antidepressant and neurological activities, depression, loss of muscle and bone, and neuropathic pain. In future, higher utilisation of curcumin as an active agent in food based products is required to curtail the human health disorders.

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Protective Effects of Curcumin against Oxidative Damage on Skin Cells In Vitro: Its Implication for Wound Healing

Abstract: The findings indicate that curcumin indeed possessed powerful inhibition against hydrogen peroxide damage in human keratinocytes and fibroblasts.

Cited by 213 publications

References 23 publications

A comparative study on the antioxidant and immunomodulatory properties of curcumin conjugated gold nanospheres and free curcumin

A comparative study on the antioxidant and immunomodulatory properties of curcumin conjugated gold nanospheres and free curcumin

Investigating the use of curcumin-loaded electrospun filaments for soft tissue repair applications

Curcumin and its allied analogues: epigenetic and health perspectives - a review

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