Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death

Park, Euteum; Chun, Hong Sung

doi:10.1248/bpb.b17-00160

Cited by 17 publications

(15 citation statements)

References 43 publications

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“…Despite the hydrophilic nature of TA/MnP-PVPON, there is a reasonable concern about its cytotoxicity due to cationic pyridinium groups and manganese cations , of the MnP pendant groups which can be cytotoxic if released from PVPON. To examine the potential cytotoxic effects of TA/MnP-PVPON, we performed an MTT assay to assess the viability of splenocytes from NOD mice, a spontaneous mouse model of Type 1 diabetes, following a 48 h incubation with (PVPON/TA) 2 (MnP-PVPON/TA) 2 (PVPON/TA), and (PVPON/TA) 2 (MnP-PVPON/TA) 2 (PVPON/TA) 1.5 capsules, with (PVPON/TA) 5 and (PVPON/TA) 5.5 as negative cytotoxicity controls .…”

Section: Resultsmentioning

confidence: 99%

Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers

et al. 2018

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Local modulation of oxidative stress is crucial for a variety of biochemical events including cellular differentiation, apoptosis, and defense against pathogens. Currently employed natural and synthetic antioxidants exhibit a lack of biocompatibility, bioavailability, and chemical stability, resulting in limited capability to scavenge reactive oxygen species (ROS). To mediate these drawbacks, we have developed a synergistic manganoporphyrin-polyphenol polymeric nanothin coating and hollow microcapsules with efficient antioxidant activity and controllable ROS modulation. These materials are produced by multilayer assembly of a natural polyphenolic antioxidant, tannic acid (TA), with a synthesized copolymer of polyvinylpyrrolidone containing a manganoporphyrin modality (MnP-PVPON) which mimics the enzymatic antioxidant superoxide dismutase. The redox activity of the copolymer is demonstrated to dramatically increase the antioxidant response of MnP-PVPON/TA capsules versus unmodified PVPON/TA capsules through reduction of a radical cationic dye and to significantly suppress the proliferation of superoxide via cytochrome C competition. Inclusion of MnP-PVPON as an outer layer enhances radical-scavenging activity as compared to localization of the layer in the middle or inner part of the capsule shell. In addition, we demonstrate that TA is crucial for the synergistic radical-scavenging activity of the MnP-PVPON/TA system which exhibits a combined superoxide dismutase-like ability and catalase-like activity in response to the free radical superoxide challenge. The MnP-PVPON/TA capsules exhibit a negligible, 8% loss of shell thickness upon free radical treatment, while PVPON/TA capsules lose 39% of their shell thickness due to the noncatalytic free-radical-scavenging of TA, as demonstrated by small angle neutron scattering (SANS). Finally, we have found the manganoporphyrin-polyphenol capsules to be nontoxic to splenocytes from NOD mice after 48 h incubation. Our study illustrates the strong potential of combining catalytic activity of manganoporphyrins with natural polyphenolic antioxidants to design efficient free-radical-scavenging materials that may eventually be used in antioxidant therapies and as free radical dissipating protective carriers of biomolecules for biomedical or industrial applications.

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Section: Resultsmentioning

confidence: 99%

Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers

et al. 2018

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“…Shin et al [61] reported that curcumin (200 mg/kg by intraperitoneal route (i.p.)) reduced kainic acid-induced seizures in mice through the increased expression of HO-1 and endothelial nitric oxide synthase (eNOS) in hippocampal astrocytes, whereas Park and Chun [62] demonstrated that curcumin (0.1–10 µM) reduces oxidative stress, apoptosis, and mitochondrial damage through the direct involvement of HO-1 in BV-2 microglial cells.…”

Section: Curcumin Neuroprotection and The Ho/bvr Pathwaymentioning

confidence: 99%

Curcumin and Heme Oxygenase: Neuroprotection and Beyond

Mhillaj

Tarozzi

Pruccoli

et al. 2019

IJMS

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Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti-inflammatory pathways involved in neurodegeneration. Although its poor systemic bioavailability after oral administration and low plasma concentrations represent restrictive factors for curcumin therapeutic efficacy, innovative delivery formulations have been developed in order to overwhelm these limitations. This review provides a summary of the main findings involving the heme oxygenase/biliverdin reductase system as a valid target in mediating the potential neuroprotective properties of curcumin. Furthermore, pharmacokinetic properties and concerns about curcumin’s safety profile have been addressed.

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“…these results in mat be caused by the ability of curcumin to prevent GSH decrease, thus protecting the cell from caspase 3 activation and DNA fragmentation [38]. On the same line, [39] concluded downregulation of caspase 3 expression, as well as elevation of intracellular GSH level in manganese exposed microglial cells.…”

Section: Discussionmentioning

confidence: 95%

Ethnopharmacological Study of Brain Oxidative Stress Improving Potential of Curcumin in Intoxicated Rats

Elsayed

2021

Int J Pharm Pharm Sci

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Objective: The following study aimed to investigate the efficacy of curcumin at preventing amikacin neurotoxicity Methods: Twenty-four male Wister albino rats were randomly divided into four groups including-G (1): control group includes six rats, they were administered 0.5 ml of saline orally for 14 consecutive days. G (2): includes six rats; they were administered 200 mg/kg curcumin orally for 14 consecutive days. G (3): includes six rats, they were administered 300 mg/kg body weight/day of amikacin intraperitoneally for 14 consecutive days G (4): includes six rats, they were administered 200 mg/kg curcumin orally concurrently with 300 mg/kg body weight/day of amikacin. All animals were kept in the same conditions from feed, heat and humidity. Results: According to the result obtained after sacrification of all animals after the end of 14 d, Results revealed that amikacin at the dose rate of 300 mg/kg b. wt for 14 d induces significant changes in oxidative stress markers compared to the control group, a significant reduction in CAT. SOD. GSH (1.51±0.16, 77.00±0.73 and 84.06±4.42) respectively compared to control (3.63±0.11, 98.48±0.18 and 117.05±0.52) along with a significant increase in MDA activity (219.02±3.34) compared to control group (180.42±0.19), That indicate oxidative stress effect of it. On the beneficial side rats received amikacin 300 mg/kg B. wt I/p concurrently with 200 mg/kg b. wt curcumin for successive 14day result in a significant increase in CAT. SOD. GSH (2.23±0.09,92.00±0.26, 102.25±1.71) and decrease in MDA concentration (139.23±3.89) compared to amikacin treated group levels along with histopathological changes appear in brain tissue in the group treated with amikacin include nuclear pyknosis and degeneration in some neurons in the hippocampus, multiple focal eosinophilic plaque formation in the striatum also this results enhanced by activated caspase-3 expression in the brain tissue following amikacin administration. Conclusion: The present study proved that Oral administration of curcumin at the dose of 200 mg/kg for 14 d concurrently with amikacin significantly mitigates its neurotoxic and oxidative stress effects.

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Protective Effects of Curcumin on Manganese-Induced BV-2 Microglial Cell Death

Cited by 17 publications

References 43 publications

Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers

Manganoporphyrin-Polyphenol Multilayer Capsules as Radical and Reactive Oxygen Species (ROS) Scavengers

Curcumin and Heme Oxygenase: Neuroprotection and Beyond

Ethnopharmacological Study of Brain Oxidative Stress Improving Potential of Curcumin in Intoxicated Rats

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