Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats

Kumaş, Meltem; Eşrefoğlu, Mukaddes; Bayındır, Nihan; Iraz, Mustafa; Ayhan, Sıddıka Kesgin; Meydan, Sedat

doi:10.14235/bs.2016.788

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Diclofenac has a beneficial effect on oxidative/antioxidants balance as it downregulates OSI and increases total thiols [ 47 ]. By reducing oxidative stress, Curcumin also reduces OSI [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Boarescu

Pop

et al. 2021

Biomedicines

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We investigated the in vivo effect of curcumin nanoparticles (nC) in addition to diclofenac sodium on local edema and oxidative stress parameters in carrageenan-induced paw edema on rats. Seven groups were investigated: control group (C), the acute inflammation (AI) group, an AI group treated with Diclofenac (AID, 5 mg/kg b.w. Diclofenac sodium), two AI groups treated with cC (conventional Curcumin)—AIC200 and AIcC200D (D = Diclofenac, 200 represent the concentration of active substance expressed in mg/kg b.w.), and two AI groups with nC (Curcumin nanoparticles)—AIC200 and AIcC200D. Serum and tissue oxidative stress was assessed by measuring five parameters. Curcumin nanoparticles alone and in combination with D better reduced the paw edema than D alone (p < 0.027). The rats treated with D and nC (AIcC200D) had the highest inhibition percentage on edema, reaching the maximum level of inhibition (81%) after 24 h. Conventional curcumin and nC presented antioxidant effects in acute inflammation, with significantly better results obtained for nC. The pro-oxidant markers were reduced up to 0.3 by the cC and up to 0.4 times by the nC and both solutions increased the antioxidant markers up to 0.3 times. The nC enhanced the antioxidative efficacy of D, as this combination reduced the pro-oxidant markers up to 1.3 times. Curcumin nanoparticles could represent a therapeutic option in association with classical nonsteroidal anti-inflammatory medication in acute inflammation, as they might offer a reduction of drug dose and possible limitation of their associated side effects.

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Section: Discussionmentioning

confidence: 99%

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Boarescu

Pop

et al. 2021

Biomedicines

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“…The kidney is the target organ of cadmium toxicity and exposure to it causes tissue damage represented by the destruction of the tubules, the appearance of gaps between them, the destruction of the glomeruli, the fibrosis of the region, the infiltration of the monocyte, bleeding, fluid collection and necrosis in the kidney tissue (42). Glycogen is deposited in the kidney cells and wrinkles glomeruli, which disrupts their work (43).…”

Section: Cadmium Toxicity In Kidneysmentioning

confidence: 99%

Cadmium Toxicity and some Target Organs: A Review

Farhan¹,

Jasim²

2020

AJVS

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Cadmium is dangerous pollutant in environment because it is difficult to excrete out of the body. It causes disease in humans and animals. When the body absorbs large quantities of cadmium or when constantly exposed to small quantities, it is toxic to the body. Cadmium affects many parts of the body, the most important of which are the liver, kidneys, lungs, and testes. Both the liver and the kidney are considered organs to excrete toxins, such as heavy metals. Therefore, they are most influenced by cadmium. This study focuses on the toxicity of cadmium in the liver, kidneys, lungs and testes and its toxic effects on the histological, cellular, and functional level of each organ. We will discuss the mechanism through which cadmium causes damage to the organs of the body and the interaction that results from it.

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The Effects of Chitosan Oligosaccharide (COS) Treatment on Oxidative Stress and Its Relation with Intestinal Microflora in Rats Exposed To Cadmium

Kısadere¹,

Tavşanlı²,

Gökmen³

2020

Kocatepe Veterinary Journal

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The aim of the study was to investigate the effects of chitosan oligosaccharide (COS) treatment on oxidative stress and its relation with intestinal microflora in rats exposed to chronic cadmium toxicity. Animals were randomly divided into four groups as control (C; n=8), cadmium (Cd; n=8), chitosan oligosaccharide (COS; n=8), cadmium+chitosan oligosaccharide (Cd+COS; n = 8). After, cadmium chloride (CdCl2) (2mg /kg/ day) was orally administered to Cd and Cd+COS groups three times a week for 4 weeks. Chitosan oligosaccharide (200 mg/kg/day) was also orally administered to COS and Cd+COS groups five times a week for 4 weeks. After completion of the experiment, serum TAS, TOS levels, plasma ALT, AST, GGT, T.pro, Alb, Bil, Creat and BUN values were measured. Enterobacteriaceae, Lactococcus spp. and Lactobacillus spp. counts were also detected. Serum TOS values were detected extremely higher in Cd group animals when compared COS group (p <0,05). In the small intestine of the Cd group animals, Cd administration caused a 0.66 log decrease in the Lactococcus spp. count. In conclusion, it was found that the antimicrobial effect of both compounds decreased as a result of COS-Cd chelating in Cd + COS group.

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Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats

Cited by 4 publications

References 29 publications

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Cadmium Toxicity and some Target Organs: A Review

The Effects of Chitosan Oligosaccharide (COS) Treatment on Oxidative Stress and Its Relation with Intestinal Microflora in Rats Exposed To Cadmium

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