Protective effects of cyanidin‐3‐O‐glucoside on UVB‐induced chronic skin photodamage in mice via alleviating oxidative damage and anti‐inflammation

Abstract

Excessive ultraviolet (UV) radiation exposure results in skin chronic photodamage via stimulating reactive oxygen species (ROS) and inflammation. Anthocyanins are a group of flavonoids frequently found in edible plants. Cyanidin-3-O-glucoside (C3G) as a typical anthocyanin shows effective anti-oxidative and anti-inflammatory properties. This study aims to investigate whether the topical application of C3G moisturizing gel on mice can protect the skin from UVB-induced chronic photodamage. The results of in vitro experiment showed that the active ingredient C3G can penetrate the mice skin. The dorsal of Kunming mice were treated with C3G moisturizing gel (100, 200, 300 μmol/L) after UVB exposure. The animal experiment demonstrated that C3G can reduce chronic photodamage caused by UVB. C3G could effectively ameliorate the UVB-induced epidermal barrier dysfunction including an increase in the skin hydration and decrease in the transepidermal water loss, and have statistically significance. Besides, our results also indicated that C3G inhibited UVB-induced epidermal hyperplasia, the destruction of collagen fibers, ROS levels, and the expression of COX-2 and IL-6. In brief, these results indicate that C3G can reduce UVB-induced chronic photodamage by inhibiting oxidative stress and inflammation.

Structural identification and in vitro antioxidant activities of anthocyanins in black chokeberry (Aronia melanocarpa lliot)

“…It has great application potential in the development of food and medicinal products. Research shows that anthocyanin has antiaging [13] antioxidant [14,15] , antiproliferative [16], antiinflammatory [17][18][19] , cardiovascular disease treatment [20,21] , neuroprotective [22], cholesterol reduction [23,24] , anticancer [25], stomach preservation [26], liver protection [27], and anti-ultraviolet radiation b (UVB) irradiation activity [28] and so on.…”

Molecular mechanisms of the chemical constituents from anti-inflammatory and antioxidant active fractions of Ganoderma neo-japonicum Imazeki

“…Oxidative stress levels determine the immune response of the body and regulate the production of inflammatory cytokines during viral infection ( Dragomanova et al, 2021 ).Although inflammation is a protective immune function against pathogen infection and danger signals, excessive and continuous inflammation can cause tissue damage and functional obstacles (Z. Liu et al, 2018 ; Peng et al, 2020 ). Anti-inflammatory therapy is also one of the effective strategies to suppress the cytokine storm of COVID-19 infection and other inflammatory diseases.…”

Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages

“…Excessive NO production is a typical sign of inflammation in activated RAW264.7 cells ( Peng et al, 2020 ). The nitric oxide release in the LPS group was significantly higher than the control group ( p < 0.0001) (data not shown).…”