Protective Effects of Daidzein on Oxidative Stress-Induced Neurotoxicity and Scopolamine-Mediated Cognitive Defect

This study's objective was to clarify the ameliorative effects ferulic acid (4-hydroxy-3-methoxycinnamic acid) has against cognitive deficits and ChAT activation in trimethyltin (TMT) induced, memory injured mice following a 28-d ferulic acid treatment. After administering TMT for 3 d, each mouse performed Y-maze and passive avoidance tests to check immediate working memory performance and cognitive function. The results showed that ferulic acid administration attenuated TMT-induced memory injury and a decline in ChAT activity in the mice. This suggests that ferulic acid might be useful for preventing cognitive dysfunction as well as for boosting the activation of ChAT in dementia.

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Protective Effects of Daidzein on Oxidative Stress-Induced Neurotoxicity and Scopolamine-Mediated Cognitive Defect

Abstract: mine-induced cognitive deficit and that its anti-amnesic effect might be due to the activation of choline acetyltransferase. acetyltransferase. acetyltransferase. acetyltransferase. acetyltransferase.

Cited by 5 publications

References 25 publications

Daidzein’s potential in halting neurodegeneration: unveiling mechanistic insights

Daidzein’s potential in halting neurodegeneration: unveiling mechanistic insights

Inclusion complexes of isoflavones with two commercially available dendrimers: Solubility, stability, structures, release behaviors, cytotoxicity, and anti-oxidant activities

Ferulic Acid Supplementation Prevents Trimethyltin-Induced Cognitive Deficits in Mice

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