Protective Effects of Dexmedetomidine and Oxycodone in Patients Undergoing Limb Ischemia-Reperfusion

Cheng, Wenjie; Wang, Mingjie; Liu, Peng; Zhao, Shuang; Liu, Xin; Wang, Xiuli

doi:10.12659/msm.918261

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…Both clinically and experimentally, different molecules have been proposed for the prophylactic pharmacological treatment of IRI: (a) antioxidant compounds, such as equivalents of superoxide dismutase (SOD), malondialdehyde (MDA), allopurinol, melatonin, N-acetylcysteine (NAC) [ 12 , 13 , 14 , 15 ]; (b) statins [ 16 , 17 ]; and (c) anesthetics, such as propofol, sevoflurane, dexmedetomidine or oxycodone [ 18 , 19 ]. Another proposed therapeutic approach is the so-called “ischemic conditioning”, first described in myocardium [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Folinic Acid Administration on Lower Limb Ischemia/Reperfusion Injury in Rats

et al. 2021

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Surgery under ischemic conditions, lasting up to 3 h, is routinely performed in orthopedic surgery, causing undesirable injury due to ischemia-reperfusion syndrome, with short and medium-term functional repercussions. To date, there is no established prophylactic treatment. In this work we evaluated folinic acid (FA) in a rodent model of lower limb ischemia-reperfusion (IRI-LL). 36 male WAG rats underwent 3 h of lower limb ischemia. In the saline group, rats received intraperitoneal administration of saline (used as vehicle for treatment). In the experimental group, rats were pretreated with FA (2.5 mg/kg) before the end of ischemia. After ischemia, animals were sacrificed at 3 h, 24 h or 14 days (for biochemical determination (Na+, K+, Cl-, urea, creatinine, CK, LDH, ALP, ALT, and AST), pathological assessment, or functional study using the rotarod test; respectively). Another six animals were used to establish the reference values. The prophylactic administration of FA significantly reduced the elevation of biochemical markers, especially those that most directly indicate muscle damage (CK and LDH). In addition, it also improved direct tissue damage, both in terms of edema, weight, PMN infiltrate and percentage of damaged fibers. Finally, the administration of FA allowed the animals to equal baseline values in the rotarod test; what did not occur in the saline group, where pre-ischemia levels were not recovered. Following 3 h of lower limb ischemia, FA minimizes the increase of CK and LDH, as well as local edema and leukocyte infiltration, allowing a faster recovery of limb functionality. Therefore, it could be considered as a prophylactic treatment when tourniquet is used in clinics.

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Section: Introductionmentioning

confidence: 99%

Effects of Folinic Acid Administration on Lower Limb Ischemia/Reperfusion Injury in Rats

et al. 2021

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“…Oxycodone, for instance, has antioxidant and anti-inflammatory properties that protect against surgical stress by inhibiting the production of proinflammatory cytokines and lipid peroxidation. 5 Therefore, it would be of interest to perform a more comprehensive analysis of potential pharmacologic influence on the results.…”

Section: To the Editormentioning

confidence: 99%