Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis

Karadağ, Ahmet; Оздемир, Рамазан; Kurt, Ahmet; Parlakpınar, Hakan; Polat, Alaadin; Vardı, Nigar; Taşlıdere, Elif; Karaman, Abdurrahman

doi:10.1016/j.jpedsurg.2014.10.053

Cited by 31 publications

(16 citation statements)

References 32 publications

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“…All of these play a major role in cellular defense and in the repair systems against oxidative stress and inflammatory response. A large number of experiments have proved that dexpanthenol has anti‐inflammatory and antioxidant properties (Karadag et al, ; Liew, Jee, Yap, & Yong, ; Ozdemir et al, ). Based on the above evidence, the increase in pantothenic acid in the MF‐treated group contributed to alleviating lung injury.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Wang¹,

Liu²,

Cao³

et al. 2018

Biomedical Chromatography

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This study aimed to investigate the efficacy of mangiferin, including its known antioxidant and anti-inflammatory effects on sepsis-induced lung injury induced by a classical cecal ligation and puncture (CLP) models in mouse using a metabolomics approach. A total of 24 mice were randomly divided into four groups: the sham group was given saline before sham operation. The CLP group received the CLP operation only. HMF and LMF groups were given mangiferin treatment of high dose and low dose of mangiferin, respectively, before the CLP operation. One week after treatment, the mice were sacrificed and their lungs were collected for metabolomics analysis. We developed ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry to perform lung metabolic profiling analysis. With the methods of principal component analysis and partial least squares discriminant analysis, 58 potential metabolites associated with amino acid metabolism, purine metabolism, lipid metabolism and energy regulation were observed to be increased or reduced in HMF and LMF groups compared with the CLP group. Conclusively, our results suggest that mangiferin plays a protective role in the moderation of sepsis-induced lung injury through reducing oxidative stress, regulating lipid metabolism and energy biosynthesis.

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Section: Discussionmentioning

confidence: 99%

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Wang¹,

Liu²,

Cao³

et al. 2018

Biomedical Chromatography

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“…Dexpanthenol (DXP) is an alcoholic analog of pantothenic acid which is oxidized to pantothenic acid inside the peripheral tissues. It reduces the ultraviolet‐induced decrease of glutathione content, attenuates lipid peroxidation, and partly protects the cells against apoptosis produced by ultraviolet irradiation 2,3 . It also induces the co‐enzyme A and ATP synthesis within the cell.…”

mentioning

confidence: 99%

Dexpanthenol may be a novel treatment for male androgenetic alopecia: Analysis of nine cases

Kutlu

2020

Dermatologic Therapy

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“…Also as these newer modalities are expensive, the ability to define a population which may be at risk for developing severe disease, these diagnostic and treatment modalities can be used judiciously for at risk population. [27][28][29][30] Our findings are limited by the retrospective nature of our study, although we validated the data extraction from charts, variation in nursing documentation of clinical signs may have altered our findings. Use of this multi-parameter scoring tool to determine whether more aggressive treatment for at risk infants for developing NEC stage 2 and 3, even before radiological confirmation of pneumatosis intestinalis, may result in a less severe course of NEC and improve morbidity and mortality.…”

Section: Discussionmentioning

confidence: 83%

Early prediction of severity of necrotizing enterocolitis in preterm infants: A composite scoring tool

Grino

Miller

Carrasquilla-Lopez

et al. 2016

Clinical Nursing Studies

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Background: Necrotizing enterocolitis (NEC) predominantly affects preterm infants and is associated with high mortality and morbidity. There is no composite scoring tool that predicts the severity of NEC in preterm infants early in the disease process before it is established. Methods: A retrospective chart review was performed on NEC cases (n = 41) defined as infants who developed NEC stage ≥ 2 with pneumatosis intestinalis, and controls (n = 41) defined as infants with NEC stage 1, to develop a scoring tool that utilized the preterm infant's clinical status, feeding practices, radiographic and laboratory findings at set time-points (7 days, 2 days and 24 and 12 hours) before the suspicion of NEC to predict the severity of NEC. Repeated measures analysis along with sensitivity, specificity and area under curve were measured to compare the composite risk score between cases and controls. Results: The composite risk score was higher among the cases at 24 hours (2.73 ± 0.20 vs. 2.20 ± 0.20, p < .05) and 12 hours (4.20 ± 0.22 vs. 2.50 ± 0.22, p < .001) but not on 2 day (2.37 ± 0.17 vs. 2.18 ± 0.17, p = .42) prior to the suspicion of NEC to predict the severity of the disease. Feeding practices, gastric residuals, and laboratory signs of inflammation were main determinants of the final score. The most discriminatory score to differentiate between NEC stage 1 and NEC stage 2 and 3 was ≤ 2. Conclusions: This scoring system is easy to use as it utilizes normally collected data and can predict the severity of the disease enabling the physician to make decisions regarding appropriate timing of correct treatment. Further larger prospective studies are required to validate this pilot study describing NEC severity prediction tool.

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Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis

Cited by 31 publications

References 32 publications

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Dexpanthenol may be a novel treatment for male androgenetic alopecia: Analysis of nine cases

Early prediction of severity of necrotizing enterocolitis in preterm infants: A composite scoring tool

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