Protective effects of Dialium guineense pulp on aspirin-induced gastric mucosal injury in albino rats

Abstract

The numerous challenges and detrimental effects connected with the treatment of peptic ulcers in the world today calls for alternative attention. Ethnomedicinally, Dialium guineense pulp (DAGP) has numerous pharmacological activities. This study investigated the antiulcer activities of Dialium guineense pulp on gastric mucosa injury induced with aspirin in albino Wistar rats. DAGP extract was orally administered at doses of 250, 500 and 1000 mg/kg bw (mg per kg of the body weight) per day for 3 or 7 days followed by 400 mg/kg bw oral aspirin administration. Ulcer indices were determined, followed by a biochemical estimation of antioxidant enzymes using gastric mucosal tissue from the stomach. Student's t-test was used to compare significant differences among groups of animals at P ≤ 0.05. The results showed that Dialium guineense pulp caused a significant decrease (P ≤ 0.05) in the ulcer index in aspirin induced rats. This decrease in ulcer index is dose dependent and 1000 mg/kg bw per day caused the highest decrease in 7 days. The results showed a significant increase (P ≤ 0.05) in lipid peroxidation and a decrease (P ≤ 0.05) in antioxidant enzymes activities in the aspirin-induced ulcerated rats. Oral administration of DAGP increased antioxidant enzymes activities and decreased injury in the gastric mucosa in ulcer induced rats. Therefore, this study showed that DAGP exhibited anti-ulcer potential and that the gastrointestinal protection may be through the scavenging action of free radicals by its constituent antioxidants. Thus, Dialium guineense pulp has ameliorative medicinal potential for the curing of gastric disorders.

Anti-Ulcerogenic and Toxicological Evaluation of Polyphenol Rich Extract of Cochlospermum Planchonii Roots in Tissues of Aspirin-Induced Ulcerogenic Rats

“…Thus, the increase in the aggressive factors aforementioned following the administration of Aspirin in this study confirmed that ulcerative stage has been established suggesting a good model for ulceration in rats. This finding is similar to those previous studies [26][27][28]. Likewise, the volume of the gastric juice and acidity are inversely proportional to the pH of the juice, this indicates that the low pH observed in this study is a reflection of the increase in gastric acid secretion due to aspirin administration.…”