Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent

Abstract

The efficacy of dietary curcumin in TNBS colitis varies in BALB/c and SJL/J mouse strains. Although the exact mechanism underlying these differences is unclear, the results suggest that the therapeutic value of dietary curcumin may differ depending on the nature of immune dysregulation in IBD.

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

“…• Inhibited the TNBS-induced colitis and splenocyte proliferation in BALB/c mice but not in NKT-deficient SJL/J mice (Billerey-Larmonier et al, 2008).…”

“…Numerous reports have been published suggesting that oral administration of curcumin down-regulates TNF-a expression both in the serum and in the tissue of animals (Nanji et al, 2003;Yao et al, 2004;Sharma et al, 2007a;Billerey-Larmonier et al, 2008;Larmonier et al, 2008;Ung et al, 2010;El-Moselhy et al, 2011;Gutierres et al, 2012) ( Table 2). Attenuation of TNF-a levels by curcumin has been noted in mice (Leyon and Kuttan, 2003), rats (Siddiqui et al, 2006) and rabbits (Yao et al, 2004;Huang et al, 2008).…”

Curcumin inhibits interferon-γ signaling in colonic epithelial cells

“…Up to 8 g daily administered to patients for 3 mo did not cause toxicity (9). In our previously published studies, dietary curcumin supplementation leading to colitis prevention resulted in millimolar concentrations within the colonic lumen with no observable toxicity (6,26). However, in both humans and laboratory rodents, curcumin displays very low bioavailability with poor absorption and rapid metabolic elimination (3).…”

275 The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

“…Our laboratory has extensively studied the anti-inflammatory benefits of curcumin in murine IBD models. [17][18][19] More recently, we also demonstrated that curcumin inhibits colon cancer cell migration through physical interaction with and activation of PTPN1 tyrosine phosphatase to reduce the abnormally hyperphosphorylated and hyperactive form of cortactin, a protein implicated in cancer motility and tumor invasiveness. 20 We hypothesized that due to its poor bioavailability, orally administered curcumin as a dietary supplement targets and impacts primarily epithelial cells and the gut microbiota, and that curcumin may modulate colonic microbial ecology and prevent the progression of chronic colitis to CAC.…”