Protective effects of dietary polyphenols from black soybean seed coats on islet and renal function in streptozotocin‐induced diabetic rats

Qiu, Ju; Zhu, Hong; Liu, Peng; Wang, Jing; Lu, Lingang

doi:10.1002/jsfa.8726

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Previous studies identified anthocyanins and procyanidins as the two main types of polyphenols and described their antidiabetic effects. Qiu et al [92] demonstrated that the phenolic-enriched crude extract increased the concentrations of serum insulin and GLP-1 in streptozotocin-induced diabetic rats after 8 weeks of treatment. However, they did not identify any specific compound in the extract.…”

Section: Natural Products As Stimulants Of Glp-1 and Gip Secretionmentioning

confidence: 99%

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

et al. 2019

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Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.

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Section: Natural Products As Stimulants Of Glp-1 and Gip Secretionmentioning

confidence: 99%

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

et al. 2019

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“…Peony total glucosides prevent renal tubular interstitial damage in rats with diabetic nephropathy and delay the development of diabetic nephropathy [37]. HEI DOU reduces blood sugar, blood lipids, serum creatinine, and blood urea nitrogen in streptozotocin (STZ)-induced diabetic rats [38], and long-term low-dose HEI DOU protects diabetic renal insu ciency [39]. Although, the effects of individual components of QBYSF have been examined in diabetic murine models and in patients, the mechanism of QBYSF on diabetic kidney disease is not clear yet.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology-Based Investigation into the Mechanisms of Qibangyishen Formula for the Treatment of Diabetic Kidney Disease

Wang

2021

Preprint

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Background Diabetic kidney disease is the main microvascular complication of diabetes, and new treatment strategies are needed. We investigated the multi-component, multi-target, and multi-path mechanism of Qibangyishen formula for the treatment of diabetic kidney disease by network pharmacology methods. Methods We collected the active ingredients and targets of Qibangyishen formula and examined diabetic kidney disease-related genes by searching the ETCM, TCMID, and DisGeNet databases. We constructed and analyzed the genetic network through Cytoscape software and used the STRING platform for pathway enrichment analysis. Results We uncovered 421 active ingredients of Qibangyishen formula, corresponding to 748 targets. A network analysis screen revealed 47 hub-node targets, and 13 of these targets were diabetic kidney disease-related disease genes. Further functional analysis identified 26 targets acting on 11 pathways related to the development of diabetic kidney disease, including PI3K-Akt, thyroid hormone, neurotrophin, Wnt, chemokine, and osteoclast differentiation signaling pathways. Conclusions This study suggests that Qibangyishen formula regulates multiple genes and biological processes related to diabetic kidney disease and provides a foundation for further research and clinical applications.

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