Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats

Ozmerdiven, Gokhun; Vuruşkan, Berna Aytaç; Kaygısız, Onur; Vuruşkan, Hakan

doi:10.4149/bll_2017_045

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…In the study of Sugimoto et al [ 17 ] investigating the effect of tadalafil at a dose of 10 mg/kg for 30 days in the rat prostate in a nonbacterial prostatitis model, it was reported that tadalafil showed anti-inflammatory and stromal anti-proliferative effects at this dose and time. In addition these, in the study of Özmerdiven et al, it was reported that tadalafil had positive effects on post-ESWL renal damage [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, it is possible to find many studies using tadalafil as an exogenous antioxidant to reduce various organ damage due to ROS. However, these studies differ from each other in terms of their results [ 1 , 15 – 18 ]. With this study model, we investigated the effects of hyperoxia on the rat kidneys and whether tadalafil has an effect to reduce this damage, to shed some light on this issue.…”

Section: Introductionmentioning

confidence: 99%

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The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

et al. 2022

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Purpose Continuous oxygen therapy to compensate for decreased oxygen saturation in the blood is a life-saving treatment used in case lung involvement. Excess oxygen delivery was reported to be a common situation, in which about 50% of the patients showed hyperoxemia and 4% in severe hyperoxemia. In this work, we investigated the effects of hyperoxia on the rat kidneys and whether tadalafil has an effect to reduce this damage. Materials and methods Three groups of 8 male rats each weighing 300–350 g were formed. The groups were divided into the control group, hyperoxia group, and hyperoxia and tadalafil administered group for 10 days. At the end of the 10th day, blood and kidney samples were taken for biochemical analysis (SOD and NO levels) and histopathological examination. Results While our findings showed that SOD levels were significantly different among the control and experimental groups and within the experimental groups, no statistical difference was found in terms of NO levels among the groups (Table 1). While the glomerular and tubular injury was higher in the Hyperoxia group and the Hyperoxia + Tadalafil group than in the control group ( p < 0.001), as a result of the rate of severe glomerular and tubular injury in the hyperoxia group, was 62.5% and 43.8% and in the group given tadalafil was 43.8% and 31.3%, respectively (Table 2). Conclusions Exposure to hyperoxia condition causes renal glomerular and tubular damage, and tadalafil does not show a protective effect on this damage according to this study’s dose and exposure time.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

et al. 2022

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Assessment of the nephroprotective efficacy of steroid therapy by analyzing concentrations of new markers of the renal damage at the extracorporeal remote shock wave lithotripsy in children

Zorkin,

Nikulin,

Semikina

et al. 2024

Russian Journal of Pediatric Surgery

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BACKGROUND: for several decades, the remote shock wave lithotripsy was a leading technique for surgical management of concretions in the upper urinary tract. The key reason for its wide spread was minimal invasion combined with high efficiency. However, it has been proven that after each lithotripsy session the acute kidney injury develops. Currently, there is no any curative strategy aimed to protect the renal parenchyma from pathological impacts of shock wave energy. AIM: to evaluate Prednisolone nephroprotective efficacy after analysing dynamic levels of biomarkers of kidney damage during the remote shock wave lithotripsy in children. METHODS: 108 children with urolithiasis after a session of remote shock wave lithotripsy were enrolled in the study. All patients were divided into two groups of 54 participants in each. Participants from the control group were treated according to the standard protocol. Participants from the studied group, in addition to the traditional therapy, were prescribed Prednisolone orally at dosage 0.5 mg/kg once a day for 2 days before the session of external shock wave lithotripsy and 2 hours before the surgery. Urine and blood samples were taken from all patients: before surgery, 45 minutes and 24 hours after it. Biomarker concentration was assessed in all samples. RESULTS: The biomarker concentration in the urine differed statistically significantly in patients of the studied group and of the control one. The most pronounced changes were noted 45 minutes after the surgery. A statistically significant concentration increase of all studied biomarkers was revealed in patients from the control group. In children from the studied group, concentration of kidney damage molecule 1 did not change, and lipocalin concentration associated with neutrophil gelatinase, tissue inhibitor of metalloproteinase 2 and hepatic forms of fatty acid binding protein increased statistically significantly less than in patients of the control group. Interleukin 18 concentration in the blood serum of patients from the control group increased statistically significantly, while in patients from the studied group - statistically insignificantly. CONCLUSION: A statistically significant decrease in the concentration of studied biomarkers, and, consequently, less degree of renal damage in the studied group, can promote implementation of the glucocorticoid therapy as a medical support during the external shock wave lithotripsy in children.

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Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review

Georgiadis

Zisis

Docea

et al. 2020

JCM

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Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is), currently available as first-line therapy of erectile dysfunction in humans, have shown a beneficial potential of reno-protection through various reno-protective mechanisms. The aim of this work is to provide a comprehensive overview of the available literature on the reno-protective properties of PDE5Is in the various forms of AKI. Medline was systematically searched from 1946 to November 2019 to detect all relevant animal and human studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. In total, 83 studies were included for qualitative synthesis. Sildenafil is the most widely investigated compound (42 studies), followed by tadalafil (20 studies), icariin (10 studies), vardenafil (7 studies), zaprinast (4 studies), and udenafil (2 studies). Even though data are limited, especially in humans with inconclusive or negative results of only two clinically relevant studies available at present, the results of animal studies are promising. The reno-protective action of PDE5Is was evident in the vast majority of studies, independently of the AKI type and the agent applied. PDE5Is appear to improve the renal functional/histopathological alternations of AKI through various mechanisms, mainly by affecting regional hemodynamics, cell expression, and mitochondrial response to oxidative stress and inflammation.

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Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats

Cited by 3 publications

References 19 publications

The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

Assessment of the nephroprotective efficacy of steroid therapy by analyzing concentrations of new markers of the renal damage at the extracorporeal remote shock wave lithotripsy in children

Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review

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