Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis

Gong, Guohua; Yuan, Qin; Huang, Wen; Zhou, Shu; Wu, Xiaohua; Yang, Xiaohua; Zhao, Yinlan; Li, Dan

doi:10.1016/j.cbi.2010.02.005

Cited by 99 publications

(62 citation statements)

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“…Hypolipidemic and antioxidative effects of diosgenin was observed in rats fed with high fat and high cholesterol diet (Gong et al 2010). Diosgenin also reduces intracellular ROS levels and apoptosis induced by H 2 O 2 in human vein endothelial cells (Gong et al 2010). Anti-thrombotic effect has also been attributed to diosgenin (Corbiere et al 2003;Gong et al 2011).…”

Section: Introductionmentioning

confidence: 85%

“…In previous study, we found that this agent reduces the myocardial reperfusion injury through its capacity to inhibit the production of inflammatory cytokines in rat (Ebrahimi et al 2014). Hypolipidemic and antioxidative effects of diosgenin was observed in rats fed with high fat and high cholesterol diet (Gong et al 2010). Diosgenin also reduces intracellular ROS levels and apoptosis induced by H 2 O 2 in human vein endothelial cells (Gong et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts

Badalzadeh¹,

Yavari²,

Chalabiani³

2015

gpb

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Abstract. The contribution of reactive oxygen species and oxidative stress in the pathogenesis of ischemia-reperfusion (I/R) injury has been supported by many studies. The effect of diosgenin on oxidative stress induced by I/R injury was evaluated in this study. Rat hearts were subjected to 30 minutes of global ischemia followed by 90 minutes of reperfusion. 5-hydroxydecanoate (5-HD) was used before administration of diosgenin and before ischemia. The activities of myocardial creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured. Administration of diosgenin before ischemia significantly lowered CK and MDA levels as compared with control group (p < 0.05) and increased GPX (p < 0.05) and SOD (p < 0.01) activities in comparison with control group. Pre-administration of 5-HD significantly attenuated the protective effects of diosgenin. In conclusion, opening of mitochondrial ATP-sensitive K + channels and attenuating of oxidative stress can be suggested as underlying mechanisms for cardioprotective effect of diosgenin in I/R injury.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts

Badalzadeh¹,

Yavari²,

Chalabiani³

2015

gpb

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“…The experimental model used in this study was adapted from Gong et al (2010), wherein the high-fat diet consisted of 10% powdered egg yolk, 7.5% pork fat, 1% cholesterol, 0.25% cholic acid and 81.25% of commercial diet for rats. In 100 g, the diet contained 380.9 kcal, 37.7 g carbohydrate, 21.3 g protein, 16.1 g lipids and 1237.7 mg cholesterol.…”

Section: Methodsmentioning

confidence: 99%

Effects of Consumption of Noni (Morinda citrifolia) in Rats Fed a High-Fat Diet

Machado¹,

Sousa²,

Montenegro³

et al. 2016

IJMP

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Objective: To evaluate the effects of noni consumption on risk factors for cardiovascular disease, fasting glucose and hepatic and renal function in rats fed a high-fat diet. Methods: 18 Wistar rats were divided into three groups. Group control (C) was fed with high-fat diet and water. Group's noni juice (NJ) and noni infusion (NI) received the same diet and noni juice and infusion, respectively, for 4 weeks. After this time were assessed anthropometric measurements, adiposity, organ weights and biochemical measurements. Results: Groups NJ and NI had higher waist circumference compared to group C (C=11.0 cm, NJ=12.8 cm and NI=14.0 cm, p<0.05), lower serum creatinine (C=0.8 mg/dL, NJ=0.2 mg/dL and NI=0.3 mg/dL, p<0.05), and higher blood urea nitrogen/creatinine ratio (C=92.7, NJ=349.3 and NI=230.4, p<0.05). Noni infusion consumption promoted higher serum total cholesterol (C=59.7 mg/dL, NJ=60.1 mg/dL and NI=99.8 mg/dL, p<0.05) and LDL (C=48.5 mg/dL, NJ=42.0 mg/dL and NI=78.7 mg/dL, p<0.05). Conclusion: Consumption of noni, either as juice or as infusion, promoted higher waist circumference and blood urea nitrogen/creatinine ratio. Furthermore, noni infusion consumption promoted increased of serum total cholesterol and LDL

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“…It has estrogenic activity and represents the most important bioactive phytochemical in fenugreek, used as raw precursor for the industrial, large scale synthesis of steroidal drugs and hormones such as testosterone, norethisterone, glucocorticoids and progesterone. Diosgenin also exhibited anticancer and antiaging activities, as well as cardioprotective and contraceptive properties (Aradhna et al, 1992;Liu et al, 1993;Qin et al, 1997;Dias et al, 2007;Lee et al, 2007;Tada et al, 2009;Yan et al, 2009;Gong et al, 2010;Agarwal et al, 2015). Russell Marker and colleagues developed the semisynthesis of (1995); Sharma et al (1996) Seeds Diabetes control in type 1 diabetes patients Sharma et al (1990) 4-Hydroxyisoleucine extracted from seeds Increase of insulin secretion Sauvaire et al (1998) Various parts Increased number of insulin receptors Raghuram et al (1994) Various parts Increase of insulin secretion in animals Ethan et al (2003) Alkaloids, flavonoids, saponins Decrease of lipaemia, glycaemia and cholagogic for treating diabetes mellitus Izzo et al (2005) Extract rich in saponins Decrease of hypercholesterolemia in rats Petit et al (1995) Seeds Management of long-term diabetes complications Ribes et al (1986) Seeds Decrease of glycemia in diabetic patients Sowmya and Rajyalakhsmi (1999) Various parts Treatment of hyperglycemia in type-1 diabetic rats Basch et al (2003) Aqueous extract (various parts) Ulcer protective Srinivasan (2006) Diet with 30% fenugreek seeds In female rabbits: antifertility and reduction of developing foetuses…”

Section: Diosgeninmentioning

confidence: 99%

Review on Fenugreek (Trigonella foenum-graecum L.) and its Important Secondary Metabolite Diosgenin

Chaudhary¹,

Chaudhary²,

Chikara³

et al. 2018

Not Bot Horti Agrobo

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Fenugreek (Trigonella foenum-graecum L.) is a medicinal plant used worldwide since ancient times. Its use as smelling agent and spice was documented since 15 th century. The genus Trigonella includes around 260 species diffused worldwide and belonging to Fabaceae family. In the last decades, a number of studies highlighted the biological activities and therapeutic properties of this species mainly attributed to bioactive secondary metabolites such as alkaloids, flavonoids, steroids and saponins. In particular, diosgenin, a steroidal saponin, has been investigated for its medicinal uses and fenugreek has been reported as source of raw material for the production of steroidal hormones. This review article focuses on the cultivation, genetics, ecophysiology and traditional uses of fenugreek, as well as on its medicinal properties, phytochemical and nutrient contents. Extraction procedures and pharmacological activities of diosgenin are also reviewed, as well as methods for its chemical analyses. This review focuses on the medicinal importance of Fenugreek and its important secondary metabolite diosgenin. The review article complies the results of pre-clinical studies conducted to establish the various medicinal applications of diosgenin. This will help researcher to discover fundamental role of diosgenin as a potential product for drug manufacturers and use of fenugreek as a source of diosgenin.

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Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis

Cited by 99 publications

References 50 publications

Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts

Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts

Effects of Consumption of Noni (Morinda citrifolia) in Rats Fed a High-Fat Diet

Review on Fenugreek (Trigonella foenum-graecum L.) and its Important Secondary Metabolite Diosgenin

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