Protective effects of electroacupuncture on cardiac function in rats subjected to thoracic surgery trauma

Zhang, Huan‐Huan; Xia, Chunmei; Jiang, Meiyan; Wang, Jin; Cao, Yunxia; Shen, Lei; Wang, Mengya; Zhu, Dawei

doi:10.1016/j.brainresbull.2012.06.008

Cited by 13 publications

(8 citation statements)

References 31 publications

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“…Additionally, chlorogenic acids are devoid of effects on synaptic function in ‘physiological’-like conditions and the use of slices excludes the possible involvement of peripheral effects of chlorogenic acids that can indirectly impact brain function 62 , 63 . This strongly supports a new working hypothesis that CA might affect either metabolic or antioxidant processes in astrocytes 31 or neuro-inflammatory-like reactivity in microglia 56 to indirectly control synaptic dysfunction upon hypoxia. This would be in accordance with the ability of chlorogenic acids to control antioxidant and inflammatory processes related to glial cells in in vivo models of ischemia 33 , 34 .…”

Section: Discussionsupporting

confidence: 79%

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes

Dobrachinski

Silva

et al. 2021

Sci Rep

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The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unknown if they control synaptic function. We now used electrophysiological recordings in mouse hippocampal slices to test if realistic concentrations of chlorogenic acids directly affect synaptic transmission and plasticity. 3-(3,4-dihydroxycinnamoyl)quinic acid (CA, 1–10 μM) and 5-O-(trans-3,4-dihydroxycinnamoyl)-D-quinic acid (NCA, 1–10 μM) were devoid of effect on synaptic transmission, paired-pulse facilitation or long-term potentiation (LTP) and long-term depression (LTD) in Schaffer collaterals-CA1 pyramidal synapses. However, CA and NCA increased the recovery of synaptic transmission upon re-oxygenation following 7 min of oxygen/glucose deprivation, an in vitro ischemia model. Also, CA and NCA attenuated the shift of LTD into LTP observed in hippocampal slices from animals with hippocampal-dependent memory deterioration after exposure to β-amyloid 1–42 (2 nmol, icv), in the context of Alzheimer’s disease. These findings show that chlorogenic acids do not directly affect synaptic transmission and plasticity but can indirectly affect other cellular targets to correct synaptic dysfunction. Unraveling the molecular mechanisms of action of chlorogenic acids will allow the design of hitherto unrecognized novel neuroprotective strategies.

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Section: Discussionsupporting

confidence: 79%

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes

Dobrachinski

Silva

et al. 2021

Sci Rep

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“…The results are consistent with publications of lower levels of evidence such as case reports, case series, and animal studies in the field of cardiac surgery. 20,33 The results of animal studies should be interpreted with caution, especially as a different response of opioid receptors following EA has been demonstrated in healthy animals versus animals receiving a painful stimuli. 15 To elucidate the general influence of acupuncture, Ren et al 34 examined the brain of 12 healthy volunteers in a functional magnetic resonance imaging during acupuncture application.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Electroacupuncture in Cardiac Anesthesia and Intensive Care

Asmussen

Przkora

Maybauer

et al. 2017

J Intensive Care Med

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“…Negative controls were obtained by excluding the primary antibody [34, 35]. The c-fos-positive neurons were observed under a light microscope at high-power field (HPF) magnification [36], and the average number of c-fos-positive neurons was counted single-blind using the imaging software (Image-Pro Plus, Media Cybernetics, Inc., USA).…”

Section: Methodsmentioning

confidence: 99%

Antipruritic effect of cold stimulation at the Quchi Acupoint (LI11) in Mice

Tsai

Chen

et al. 2014

BMC Complement Altern Med

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BackgroundAcupuncture and moxibustion are used to treat pruritus and atopic dermatitis. However, whether cold stimulation (defined as that the temperature conducted under skin temperature) of acupoints affects itching in experimental murine models remains unclear.MethodsThe present study was designed to determine the therapeutic effects of different thermal stimulations at the Quchi acupoint (LI11) in a murine model in which scratching behaviour was elicited by subcutaneous injection with a pruritogenic agent (compound 48/80). Male ICR mice were divided into several groups as follows: control (saline), those receiving compound 48/80 and compound 48/80 with various thermal stimulations (5°C–45°C) at LI11 (n = 6 per group). The scratch response of each animal to these stimulations was recorded for 30 min. The antipruritic effect of the acupoint was further evaluated in LI11 and sham (non-acupoint) groups (n = 6 per group).ResultsTreatment with lower temperature (20°C) at the LI11 acupoint significantly attenuated compound 48/80-induced scratching; however, this antipruritic effect was not observed with stimulation at the sham point. The expression of c-fos in the neuron of the cervical spine induced by compound 48/80 was suppressed by cold stimulation at LI11. The antipruritic effect of cold stimulation was blocked by ruthium red (RR), a non-selective transient receptor potential (TRP) channel blocker, suggesting that TRP channels may play an important role in the antipruritic effect of cold stimulation at LI11 in mice.ConclusionsThis study demonstrated that cold stimulation at LI11 attenuated compound 48/80-induced scratching behaviour in mice, possibly by a TRP-related pathway.

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Protective effects of electroacupuncture on cardiac function in rats subjected to thoracic surgery trauma

Cited by 13 publications

References 31 publications

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Meta-Analysis of Electroacupuncture in Cardiac Anesthesia and Intensive Care

Antipruritic effect of cold stimulation at the Quchi Acupoint (LI11) in Mice

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