Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Sirmali, Rana; Armağan, Abdullah; Öktem, Faruk; Uz, Efkan; Kırbaş, Aynur; Dönmez, Soner; Yilmaz, Hacı; Sılay, Mesrur Selçuk; Sırmalı, Mehmet

doi:10.3906/sag-1310-38

Cited by 18 publications

(22 citation statements)

References 31 publications

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“…24 This cellular dysfunction and disintegrity might play a role in the etiopathology of remote organ damage including liver, kidney and lung in lower limb ischemia-reperfusion injury. [3][4][5]16 The kidneys are particularly involved in the remote alteration phenomenon following skeletal muscle ischemia-reperfusion injuries. 23 Although a diversity of mechanisms exist, oxidative stress, inflammatory response, and the apoptosis are believed to be the primary causes.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, several animal studies showed that hind limb I/R injury affected several organs, including the kidneys, liver and lungs. [3][4][5] The highly selective and potent a2-adrenergic agonist dexmedetomidine (DXM) is an effective sedative, anxiolytic, and analgesic agent 6 with protective effects against I/R injury in several organs, including the heart, 7 brain, 8 and kidneys, 9 probably due to the antioxidant and anti-inflammatory properties of the compound. [10][11][12] Curcumin (CUR) has a long history of therapeutic use in Indian and Chinese medicine and has several pharmacological properties, including antioxidant, anti-inflammatory, antiviral, antimicrobial, antifungal, as well as anticancer activities.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

et al. 2016

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Curcumin and dexmedetomidine have been shown to have protective effects in ischemia-reperfusion injury on various organs. However, their protective effects on kidney tissue against ischemia-reperfusion injury remain unclear. We aimed to determine whether curcumin or dexmedetomidine prevents renal tissue from injury that was induced by hind limb ischemia-reperfusion in rats. Fifty rats were divided into five groups: sham, control, curcumin (CUR) group (200 mg/kg curcumin, n ¼ 10), dexmedetomidine (DEX) group (25 lg/kg dexmedetomidine, n ¼ 10), and curcumin-dexmedetomidine (CUR-DEX) group (200 mg/kg curcumin and 25 lg/kg dexmedetomidine). Curcumin and dexmedetomidine were administered intraperitoneally immediately after the end of 4 h ischemia, just 5 min before reperfusion. The extremity re-perfused for 2 h and then blood samples were taken and total antioxidant capacity (TAC), total oxidative status (TOS) levels, and oxidative stress index (OSI) were measured, and renal tissue samples were histopathologically examined. The TAC activity levels in blood samples were significantly lower in the control than the other groups (p < 0.01 for all comparisons). The TOS activity levels in blood samples were significantly higher in Control group and than the other groups (p < 0.01 for all comparison). The OSI were found to be significantly increased in the control group compared to others groups (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in the sham, CUR, DEX, and CUR-DEX groups, compared with the control group (p < 0.01). Rat hind limb ischemia-reperfusion causes histopathological changes in the kidneys. Curcumin and dexmedetomidine administered intraperitoneally was effective in reducing oxidative stress and renal histopathologic injury in an acute hind limb I/R rat model. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

et al. 2016

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“…Metabolites of erdosteine have two sulfhydryl groups and they take part in free radical scavenging and antioxidant activity (13). Free radical scavenging properties of erdosteine have been shown in experimental and clinical studies (1,6,7,11).…”

Section: Discussionmentioning

confidence: 99%

“…If blood flow is reestablished after reperfusion, substances produced as a result of oxidation may unexpectedly induce increased rates of mortality and morbidity because of systemic complications. Following local edema and muscle tissue necrosis, systemic inflammatory response syndrome and multiple organ failure (e.g., kidney, respiratory, and circulatory systems) generally occur as reperfusion accelerates (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

Özer¹,

Demirtaş²,

Çomu³

et al. 2018

Turk J Med Sci

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Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods:Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control' , n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion' , n = 6), and an ischemia/ reperfusion group with erdosteine at 150 mg kg -1 , intraperitoneally (group 'ischemia/reperfusion -erdosteine' , n = 6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were conducted.Results: Comparisons of the control and ischemia/reperfusion -erdosteine groups revealed similar results (P = 0.051). The values of the ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion -erdosteine groups (P < 0.0001 and P = 0.024, respectively). Relative resistance, a marker of erythrocyte deformability, was increased significantly by ischemia/ reperfusion compared to the control and ischemia/reperfusion -erdosteine groups (P < 0.05). Conclusion:We detected unfavorable effects of ischemia/reperfusion on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversing undesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies with larger volumes.

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Dexmedetomidine protects against lung injury induced by limb ischemia‐reperfusion via the TLR4/MyD88/NF‐κB pathway

Xue

Chen

Tang

et al. 2019

The Kaohsiung J of Med Scie

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Dexmedetomidine (DEX) can protect the lung from ischemia-reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. The aims of this study were to determine whether DEX attenuates lung injury following lower extremity I/R and to investigate the related toll-like receptor 4 (TLR4) signaling pathway. Twenty-eight SD rats were divided into four groups (n = 7): Sham, I/R, I/R + DEX (25 μg/kg prior to ischemia), and I/R + DEX + Atip (250 μg/kg atipamezole before DEX treatment). Lower extremity I/R was induced by left femoral artery clamping for 3 hours and followed by 2 hours reperfusion. Quantitative alveolar damage and the wet/dry (W/D) ratio were calculated. Interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)α in the bronchoalveolar lavage fluid (BALF) and serum and myeloperoxidase (MPO) in the lung were measured. The TLR4 and MyD88 mRNA expression levels were measured by RT-PCR, nuclear factor (NF)-κB, and phosphorylated NF-κB by western blot, respectively. Quantitative alveolar damage, W/D ratio, MPO, BALF and serum IL-1, IL-6, and TNF-α, and TLR4, MyD88, NF-κB, and p-NF-κB expression significantly increased in the I/R group relative to the Sham group. DEX preconditioning significantly reduced lung edema, and histological injury relative to the I/R group. Serum and BALF IL-1, IL-6, and TNF-α levels, MPO activity and TLR4, MyD88, NF-κB, and p-NF-κB expression were also significantly reduced in the I/R + DEX group compared with the I/R group. Atipamezole partially reversed all the aforementioned effects. DEX preconditioning protects the lungs against lower extremity I/R injury via α2-adrenoceptor-dependent and α2-adrenoceptor-independent mechanisms. It also suppresses the TLR4 pathway and reduces inflammation. K E Y W O R D S acute lung injury, dexmedetomidine, limb ischemia/reperfusion injury, toll-like receptor 4

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Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats

Cited by 18 publications

References 31 publications

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

Dexmedetomidine protects against lung injury induced by limb ischemia‐reperfusion via the TLR4/MyD88/NF‐κB pathway

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