“…One of the major obstacles of ovary transplantation appears to be ischemia/reperfusion (IR) injury occurring during the time period required for the revascularization of the transplanted tissue, which consequently leads to cytokine and free radical release, platelet activation, and apoptosis (Demeestere et al 2009, Hemadi et al 2009, Karaca et al 2009, Commin et al 2012, causing massive primordial follicle loss and shorter lifespan of the transplanted ovary (Demeestere et al 2009, Soleimani et al 2011. Therefore, the application of any approach to minimize ischemic injury during the initial post-transplantation period and establishment of angiogenesis in the ovarian grafts such as the choice of the transplantation site (Israely et al 2003, 2006, Soleimani et al 2008, the use of antioxidants (Nugent et al 1998, Sapmaz et al 2003, Sayyah-Melli et al 2011, angiogenic factors (Commin et al 2012), and hormonal factors (Yang et al 2008, Wang et al 2012 can play an important role in the success of ovarian tissue transplantation (Suzuki et al 2008, Yang et al 2008.…”