Protective effects of ethyl acetate fraction of <i>Lawsonia inermis</i> fruits extract against carbon tetrachloride-induced oxidative damage in rat liver

Hsouna, Anis Ben; Saoudi, Mongi; Culioli, Gérald; Blache, Yves; Ghlissi, Zohra; Chaabane, Rim; Feki, Abdelfattah El; Jaoua, Samir; Trigui, Mohamed

doi:10.1177/0748233713502839

Cited by 21 publications

(11 citation statements)

References 34 publications

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“…Pretreatment of rats with ethyl acetate fraction of fruits of Lawsonia inermis at a dose of 250 mg/kg bw and gallic acid significantly lowered some serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase. Ethyl acetate fraction and gallic acid also caused significant reduction in the hepatic thiobarbituric acid reactive substances and increased antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) in liver from oxidative stress induced by CCl4 [108].…”

Section: Hepatoprotective Activitymentioning

confidence: 95%

A Review on Lawsonia Inermis: A Potential Medicinal Plant

Al-Snafi

2019

Int J Curr Pharm Sci

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Lawsonia inermis (Family: Lythraceae) contained carbohydrates, phenolic, flavonoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin and tannins. It also contained 2-hydroxy-1,4-naphthoquinone (lawsone). Many alkaloids, naphthoquinone derivatives, phenolics and flavonoids were isolated from different parts of Lawsonia inermis. The pharmacological studies showed that Lawsonia inermis showed antibacterial, antifungal, antiparasitic, molluscicidal, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic, antiulcer, antidiarrhoeal, diuretic, anticancer and many other pharmacological effects. The current review will highlight the chemical constituents and pharmacological effects of Lawsonia inermis.Lawsonia inermis Linn (Family: Lythraceae) which is commonly known as henna, mainly present in subtropical and tropical areas and is used in all over the world. It was used for over 9000 y for its cosmetic values as a dye. The phytochemical analysis of Lawsonia inermis revealed the presence of carbohydrates, phenolic, flavanoids, saponins, proteins, alkaloids, terpenoids, quinones, coumarins, xanthones, fat, resin and tannins. It also contained 2-hydroxy-1,4naphthoquinone (lawsone). Many alkaloids, napthoquinone derivatives, phenolics and flavonoids were isolated from different parts of Lawsonia inermis. The pharmacological studies showed that Lawsonia inermis showed antibacterial, antifungal, antiparasitic, molluscicidal, antioxidant, hepatoprotective, central nervous, analgesic, anti-inflammatory, antipyretic, wound and burn healing, immunomodulatory, antiurolithiatic, antidiabetic, hypolipidemic, antiulcer, antidiarrhoeal, diuretic, anticancer and many other pharmacological effects. The current review will highlight the chemical constituents and pharmacological effects of Lawsonia inermis. Plant profile SynonymsAlcanna spinosa, Leaves of Lawsonia inermis provide an important cosmetic dye. Henna leaves were extensively used for centuries in the Middle East, the Far East and Northern Africa as dye for nails, hands, hair and textile. Henna was also used in treating skin problems, headache, jaundice, amebiasis and enlargement of the spleen [20,21]. Parts used medicinallyWhole plant, roots, fruits, stem, leaves, barks, inflorescence, rhizome, bulbs, latex, seeds, flowers and oil were used in different ailments [20]. Physiochemical characteristicsPhysiochemical investigation of leaf showed that the total ash was (14.60 %), acid insoluble ash (4.50 %), water soluble ash (3.0 %), loss on drying (4.5 %), alcohol soluble extractive value (3.8 % w/w) and aqueous extractive value (5.0 % w/w) [22]. Chemical constituentsThe preliminary phytochemical analysis of the aqueous extract of Lawsonia inermis revealed the presence of carbohydrates, phenolic compounds, flavonoids, saponins, proteins, alkaloids, terpenoids, 2 quinones, coumarins, xanthones, 6% fat, 2-3% resin and 7-8%...

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Section: Hepatoprotective Activitymentioning

confidence: 95%

A Review on Lawsonia Inermis: A Potential Medicinal Plant

Al-Snafi

2019

Int J Curr Pharm Sci

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“…Research has shown that Lawsonia inermis fruit extracts can protect the liver from oxidative stress induced by carbon tetrachloride (CCl 4 ). 79 Guha et al explored antioxidant activity of L. inermis extracts for preventing Cr(VI)-induced DNA damage. They found that the extracts showed significant potential in scavenging free radicals (DPPH • and ABTS •+ ) and Fe 3+ and in inhibiting LP.…”

Section: Chromium-carcinogenicity Chemopreventionmentioning

confidence: 99%

Carcinogenicity of chromium and chemoprevention: a brief update

Song

et al. 2017

OTT

205

103

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Chromium has two main valence states: hexavalent chromium (Cr[VI]) and trivalent chromium (Cr[III]). Cr(VI), a well-established human carcinogen, can enter cells by way of a sulfate/phosphate anion-transport system, and then be reduced to lower-valence intermediates consisting of pentavalent chromium (Cr[V]), tetravalent chromium (Cr[IV]) or Cr(III) via cellular reductants. These intermediates may directly or indirectly result in DNA damage or DNA–protein cross-links. Although Cr(III) complexes cannot pass easily through cell membranes, they have the ability to accumulate around cells to induce cell-surface morphological alteration and result in cell-membrane lipid injuries via disruption of cellular functions and integrity, and finally to cause DNA damage. In recent years, more research, including in vitro, in vivo, and epidemiological studies, has been conducted to evaluate the genotoxicity/carcinogenicity induced by Cr(VI) and/or Cr(III) compounds. At the same time, various therapeutic agents, especially antioxidants, have been explored through in vitro and in vivo studies for preventing chromium-induced genotoxicity/carcinogenesis. This review aims to provide a brief update on the carcinogenicity of Cr(VI) and Cr(III) and chemoprevention with different antioxidants.

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“…Gallic acid ( 12 ) and its derivative methyl gallate ( 13 ) are the common plant phenolics that have been isolated from the BHP of Lawsonia inermis and showed significant hepatoprotective effect at an IP (intraperitoneal) dose of 294 μ M/kg gallic acid (GA) in CCl 4 -intoxicated rats ( Figure 9 ) [ 170 ]. The study did not reveal any molecular mechanism of GA but demonstrated that the protective effect was observed by lowered serum biochemical parameters, a significant reduction of hepatic ROS, and an increase in antioxidant enzymes, as well as normalized hepatocellular necrosis, vacuolization, and inflammatory cell infiltration.…”

Section: Resultsmentioning

confidence: 99%

Section: Longamentioning

confidence: 99%

Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect

Rouf

Ghosh

Uzzaman

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Liver diseases are quite prevalant in many densely populated countries, including Bangladesh. The liver and its hepatocytes are targeted by virus and microbes, as well as by chemical environmental toxicants, causing wide-spread disruption of metabolic fuctions of the human body, leading to death from end-stage liver diseases. The aim of this review is to systematically explore and record the potential of Bangladeshi ethnopharmacological plants to treat liver diseases with focus on their sources, constituents, and therapeutic uses, including mechanisms of actions (MoA). A literature survey was carried out using Pubmed, Google Scholar, ScienceDirect, and Scopus databases with articles reported until July, 2020. A total of 88 Bangladeshi hepatoprotective plants (BHPs) belonging to 47 families were listed in this review, including Euphorbiaceae, Cucurbitaceae, and Compositae families contained 20% of plants, while herbs were the most cited (51%) and leaves were the most consumed parts (23%) as surveyed. The effect of BHPs against different hepatotoxins was observed via upregulation of antioxidant systems and inhibition of lipid peroxidation which subsequently reduced the elevated liver biomarkers. Different active constituents, including phenolics, curcuminoids, cucurbitanes, terpenoids, fatty acids, carotenoids, and polysaccharides, have been reported from these plants. The hepatoameliorative effect of these constituents was mainly involved in the reduction of hepatic oxidative stress and inflammation through activation of Nrf2/HO-1 and inhibition of NF-κB signaling pathways. In summary, BHPs represent a valuable resource for hepatoprotective lead therapeutics which may offer new alternatives to treat liver diseases.

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Protective effects of ethyl acetate fraction of Lawsonia inermis fruits extract against carbon tetrachloride-induced oxidative damage in rat liver

Cited by 21 publications

References 34 publications

A Review on Lawsonia Inermis: A Potential Medicinal Plant

A Review on Lawsonia Inermis: A Potential Medicinal Plant

Carcinogenicity of chromium and chemoprevention: a brief update

Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect

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