Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats

Xu, Qiang; Li, Q.-G.; Fan, Gang; Liu, Q.-H.; Mi, Fuli; Liu, B.

doi:10.1590/1414-431x20165286

Cited by 11 publications

(7 citation statements)

References 31 publications

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“…We assessed changes in bioelectric parameters of heart functioning ( Table 2) when acute cardiac infarction occurred and detected that P and T waves amplitudes were 3 (p<0.05) and 6 (p<0.05) times greater respectively in animals from the negative control group against falsely operated ones, and QT interval was by 87.8% longer in them. Besides, R wave amplitude was 3.3 times (p<0.05) smaller in rats from the negative control group against falsely operated animals and these data are consistent with literature [16]. Preventive introduction of Meldonium resulted in favorable dynamics of changes in cardiac muscle electrophysiology in rats under cardiac infarction as P wave amplitude and QT interval length were 2 times (p<0.05) and by 68.7% (p<0.05) lower respectively against animals from the negative control group, and R wave amplitude was 3.2 times greater (p<0.05).…”

supporting

confidence: 92%

Cardiotropic properties of chromone-3-aldehyde derivatives under an experimental cardiac infarction complicated with hypercholesterolemia

Voronkov¹,

Pozdnyakov²,

Rukovitsyna³

et al. 2019

Health Risk Analysis

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Cardiac infarction still remains a leading cause of mortality among population. There are a lot of risk factors causing the disease and complicating it; undoubtedly, they require correction. Our research goal was to experimentally assess cardiotropic peculiarities of 4 chromone-3-aldehyde derivatives (coded as Х3АF, Х3АFOK, X3ANO 2 , and X3ANO 2 ОК) as medications aimed at minimizing risks of acute cardiac infarction complicated with hypercholesterolemia. The experiment was performed on 70 male Wistar rats (pubescent, with body weight being equal to 220-240 grams); the animals were divided into 7 equal experimental groups, 10 animals in each. The first group was made up of falsely operated animals. We modeled atherogenesis in 60 remaining rats via oral introduction of 3 % cholesterol dissolved in sunflower oil; the solution was introduced daily for 14 days. We also modeled acute cardiac infarction in them via ligating the left descending coronary artery with a silk thread. After 24 hours we performed electrocardiography to assess changes in QT range, and P, R, and T peaks amplitude. We also determined sizes of necrosis zones and ischemic damage foci in the cardiac muscle via double dying with Evans blue and tetrazolium chloride. We detected that compounds encoded as X3ANO 2 , X3ANO 2 OK, X3AF and X3AFOK had hypocholesteremic and cardiotropic effects which led to electrophysiological properties returning to physiological standards and a decrease in ischemia/necrosis zones in the cardiac muscle under cardiac infarction. Objects encoded as X3ANO 2 OK and X3AFOK were more pharmacologically active than X3ANO 2 and X3AF, and X3ANO 2 OK substance was comparable to a reference medication, Meldonium in our case, in terms of its activity. Overall, the examined substances can be considered medications able to minimize risks of acute cardiac infarction complicated with hypercholesterolemia.

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supporting

confidence: 92%

Cardiotropic properties of chromone-3-aldehyde derivatives under an experimental cardiac infarction complicated with hypercholesterolemia

Voronkov¹,

Pozdnyakov²,

Rukovitsyna³

et al. 2019

Health Risk Analysis

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“…Fentanyl protects the heart against myocardial IR injury via δ-receptor crosstalk with adenosine A1-receptors and mitochondrial K ATP-linked mechanisms. [ 27 ]…”

Section: Discussionmentioning

confidence: 99%

Cardiac preconditioning effect of ketamine–dexmedetomidine versus fentanyl–propofol during arrested heart revascularization

et al. 2020

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Background: Myocardial damage due to ischemia and reperfusion is still unavoidable during coronary surgery. Anesthetic agents have myocardial preconditioning effect. Ketamine has sympathomimetic effect, while dexmedetomidine has a sympatholytic effect in addition to anesthetic, analgesic, and anti-inflammatory properties of both the drugs. This study was carried out to compare ketamine–dexmedetomidine (KD) combination with fentanyl–propofol (FP) combination on the release of cardiac troponin T (cTnT) and outcome after coronary artery bypass graft. Patients and Methods: Ninety adult patients who underwent coronary artery bypass grafting (CABG) were assigned to receive either KD base anesthesia (KD group) or FP anesthesia (FP group). Trends of high-sensitive cTnT, CK-MB, and serum cortisol were followed in the first postoperative 24 h. Other outcomes were vital signs, weaning from cardiopulmonary bypass, tracheal extubation time, and echocardiographic findings. Results: There was a significant lower release of cTnT in KD group than FP group during its peak values at 6 h after aortic unclamping (92.01 ± 7.332 in KD versus 96.73 ± 12.532 ng.L −1 P = 0.032). significant lower levels of serum cortisol levels were noted KD group than in FP group at 6 and 12 h after aortic unclamping P < 0.001. As regard tracheal extubation time, patients assigned to KD group extubated earlier than whom in FP group 202.22 ± 28.674 versus 304.67 ± 40.598 min respectively P < 0.001. Conclusion: The use of KD during on-pump CABG confers better myocardial protective and anti-inflammatory effect than fentanyl propofol.

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“…Moreover, TSG (25 μ M) reverses OGD-R-induced neuronal injury, intracellular ROS generation, and mitochondrial membrane potential dissipation and attenuates H 2 O 2 -induced increase in [Ca 2+ ] i [ 18 ]. Xu et al [ 88 ] showed an ameliorating effect of TSG against focal cerebral I/R injury-induced apoptosis that can be attributed to its antioxidative actions. Doses of 0.038, 0.114, and 0.342 g/kg/day of TSG administered intragastrically at the onset of I/R in rats for 7 days result in a significant increase in GSH-Px and SOD activities ( P < 0.05) but a decrease in the MDA content ( P < 0.01) [ 88 ].…”

Section: Neuroprotective Effectmentioning

confidence: 99%

“…Xu et al [ 88 ] showed an ameliorating effect of TSG against focal cerebral I/R injury-induced apoptosis that can be attributed to its antioxidative actions. Doses of 0.038, 0.114, and 0.342 g/kg/day of TSG administered intragastrically at the onset of I/R in rats for 7 days result in a significant increase in GSH-Px and SOD activities ( P < 0.05) but a decrease in the MDA content ( P < 0.01) [ 88 ]. In another study that involves TUNEL staining, the intraperitoneal administration of TSG at dosages of 15 and 40 mg/kg at the onset of reperfusion after 90 min of middle cerebral artery occlusion (MCAO) in mice causes significant reductions in the brain infarct volume and the number of positive cells in the cerebral cortex compared with those of the MCAO group [ 18 ].…”

Section: Neuroprotective Effectmentioning

confidence: 99%

Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum

Zhang

Chen

2018

Oxidative Medicine and Cellular Longevity

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Polygonum multiflorum Thunb. (PM), a traditional Chinese medicinal herb, has been widely used in the Orient as a tonic and antiaging agent. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG, C20H22O9, FW = 406.38928) is one of the active components extracted from PM. TSG is an antioxidant agent, which exhibits remarkable antioxidative activities in vivo and in vitro. The antioxidant effect of TSG is achieved by its radical-scavenging effects. TSG can inhibit apoptosis and protect neuronal cells against injury through multifunctional cytoprotective pathways. TSG performs prophylactic and therapeutic activities against Alzheimer's disease, Parkinson's disease, and cerebral ischemia/reperfusion injury. It is also antiatherosclerotic and anti-inflammatory. However, the mechanisms underlying these pharmacological activities are unclear. This study aimed at reviewing experimental studies and describing the effectiveness and possible mechanisms of TSG.

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Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats

Cited by 11 publications

References 31 publications

Cardiotropic properties of chromone-3-aldehyde derivatives under an experimental cardiac infarction complicated with hypercholesterolemia

Cardiotropic properties of chromone-3-aldehyde derivatives under an experimental cardiac infarction complicated with hypercholesterolemia

Cardiac preconditioning effect of ketamine–dexmedetomidine versus fentanyl–propofol during arrested heart revascularization

Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum

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