Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

“…Figure shows a summary of the effects of RSV on AGE‐induced complications of oxidative stress, inflammatory responses, cellular immune reactions, insulin responses, and atherosclerosis. Numerous studies have revealed that AGEs induce oxidative stress by increasing the production of ROS and hepatic lipid peroxides, and decreasing hepatic glutathione levels . It has been reported that RSV dose‐dependently reduced ROS and advanced oxidation protein product levels dose‐dependently in MGO‐treated rats …”

“…Numerous studies have revealed that AGEs induce oxidative stress by increasing the production of ROS and hepatic lipid peroxides, and decreasing hepatic glutathione levels. 24,46,67 It has been reported that RSV dose-dependently reduced ROS and advanced oxidation protein product levels dose-dependently in MGO-treated rats. 24 The simultaneous increases in AGE and ROS levels in mitochondria in hyperglycemia indicates that AGEs could F I G U R E 3 A simplified mechanistic model of RSV in the neutralization of AGE-induced damaging agents.…”

Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

“…FA has also been reported as anti-inflammatory (Gohil et al 2012;Murakami et al 2002), anti-diabetic (Mancuso and Santangelo 2014;Ohnishi et al 2004;Song et al 2014), hepatoprotective (Krishnan et al 2013;Kim et al 2011;Al Maruf et al 2015;Panneerselvam et al 2013), anti-hyperlipidemic, andanti-atherogenic (Marimuthu et al 2013;Kwon et al 2010), neuroprotective Koh 2012Koh , 2013, anti-cancer, and anti-apoptotic effects (Serafim et al 2011;Thakkar et al 2014). However, the potential usefulness of this compound has not yet been explored in painful neuropathy.…”

Ferulic Acid and Naturally Occurring Compounds Bearing a Feruloyl Moiety: A Review on Their Structures, Occurrence, and Potential Health Benefits

“…Fetoni and others () provided functional in vivo evidence that FA limits noise‐induced hearing loss in the guinea‐pig, not only by its radical‐scavenging ability in the peritraumatic period, but also due to the upregulation of the cytoprotective enzyme heme oxygenase‐1 (HO‐1) in guinea‐pig cochleae. Further protective effects of FA have been recently described on kidneys (Alam and others ), the liver (Maruf and others ), intestine (He and others ), and pancreas (Roy and others ), among others.…”