Protective effects of Ficus racemosa stem bark against doxorubucin-induced renal and testicular toxicity

Abstract

Background:Ficus racemosa Linn. (Moraceae) bark is a rich source of phenolic compounds known to possess potential antioxidant activity offering numerous health benefits.Materials and Methods:The present study evaluated the protective effects of sequential acetone extract of Ficus racemosa bark at two doses (FR250; 250 mg kg-1 and FR500; 500 mg kg-1 p.o.) against doxorubicin-induced renal and testicular toxicity in rats.Results:Doxorubicin administration resulted in significant decrease (P ≤ 0.05) in total protein and glutathione concentrations, while increased (P ≤ 0.05) serum urea, creatinine and thiobarbituric acid reactive substances (TBARS). Extract pretreatment restored biochemical parameters toward normalization. FR250 and FR500 decreased serum creatinine levels by 22.5% and 44%, while serum urea levels were decreased by 30.4% and 58.8%, respectively. Extract pretreatment (500 mg kg-1) decreased TBARS and increased glutathione levels in the kidney and testis to control levels. These observations were substantiated by histopathological studies, wherein normal renal and testicular architecture was restored in FR500 group.Conclusion:Doxorubicin exposure results in pronounced oxidative stress, and administration of F. racemosa stem bark extract offers significant renal and testicular protection by inhibiting lipidperoxidation-mediated through scavenging free radicals.

Pathological and Ultra-structural Changes in Testis of Rats due to Doxorubicin Toxicity and its Amelioration with Quercetin

“…These findings are in accordance with the earlier scientists (kato et al, (2001), Patil et al, (2009), Bashandy and Amin (2012, and Ahmed et al, (2013). The interstitial tissue was widened due to severe edema and vacuoles were noticed, this could be attributed to endothelial dysfunction and oxidative stress in the vascular wall as reported by Venderamani et al, (2010) and Brilhantae et al, (2011).…”

Assessment of the Antitumor Potentiality of Newly Designed Steroid Derivatives: Pre-Clinical Study

“…The results of Ezzat et al, (2005) showed that serum ALP activity is significantly increased upon treatment of mice with DOXO versus the controls. DOXO is also known as nephrotoxic candidate that produces chronic progressive glomerular disease manifested by increased plasma creatinine and urea levels in association with extensive glomerular lesions, tubular dilatation, vacuolization of renal glomeruli, protein deposits in tubular lumen and stromal fibrosis (Injac et al, 2008;Ahmed et al, 2013). These findings explained the present results of the insignificant change in serum urea and creatinine levels in HCC group treated with DOXO (1).…”

Protective Effects of Rosmarinic Acid on Doxorubicin-Induced Testicular Damage

“…Because of its known antioxidant properties, the effects of Ficus racemosa on the kidneys and testes have been assessed, and this plant was shown to reduce DXR-induced damage in both these organs. However, it is not always possible to identify the active ingredient in plant extracts, and the authors of this previous study stressed that further studies were required to identify the active ingredient(s) [20]. In our study, we chose to use isolated RA to evaluate the effectiveness of specific molecules.…”