Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice

Han, Hyoung‐Min; Hong, Su‐Hyun; Park, Heung‐Sik; Jung, Jae‐Chul; Kim, Jong‐Sik; Lee, Yong‐Tae; Lee, Eun‐Woo; Choi, Yung Hyun; Kim, Byung‐Woo; Kim, Cheol‐Min; Kang, Kyung‐Hwa

doi:10.3892/etm.2016.3929

“…From 3 weeks postimmunization, the severity of arthritis was evaluated every 3 days. The arthritis score was quantified based on swelling and redness (graded from 0 to 4 for each paw; 0: normal; 1: slight swelling and redness; 2: moderate swelling and redness; 3: severe swelling and redness in large joints and moderate swelling and redness in small joints; 4: most severe swelling and redness in large joints and severe swelling and redness in small joints) [38].…”

Section: Induction and Clinical Assessment Of Arthritismentioning

confidence: 99%

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

Li

¹

,

Yang

²

,

Qin

³

et al. 2020

View full text Add to dashboard Cite

Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice. Results: The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws was observed in type II collagen-induced arthritis (CIA) mice. Besides, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6C hi monocytes, decreased B cells and CD4 + T cells, were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significantly higher levels of serum IL-4 and IL-17 than those in CIA mice. Conclusions: Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of the immune response in mice with CIA.

show abstract

“…A result suggest that pretreatment with noncytotoxic concentrations of fructus sophorae extract (FSE) xhibitsantiin amatoryactivitybyinhibitingin ammatorymediaandcytokinesthroughtheinactivationofNF-κB, ERK and JNK, and it may offer therapeutic potential for creating in ammatory diseases associated with macroactivity [8]. The present results suggest that FSE may protect against in ammation and bone damage, and would be a valuable candidate for further investigation as a novel anti-arthritic agent [9]. Data suggested that the addition of SOWPa (from Sanguisorba o cialis L. Rosaceae) to PRP increased the reproductive capacity of ACL bers by blocking the TLR-4/NF-κ B pathway.…”

Section: Introductionmentioning

confidence: 89%

Research on the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking

Shu

¹

,

Zhang

²

,

Wang

³

et al. 2021

Preprint

0

View full text Add to dashboard Cite

Background: To predict the mechanism of Huaijiao Diyu Decoction in the treatment of colorectal cancer. Methods: The active components and related targets of 7 kinds of Chinese medicinal materials were collected from the database of Chinese medicinal materials. CRC related targets are obtained from the Genes card database. cross targets of disease and drug targets were input into the STRING database to construct protein-protein interaction networks.GO enrichment analysis and KEGG enrichment analysis using clusterProfiler packets in the language, Finally, the interaction between core components and core targets is discussed by molecular docking.Result: TCMSP database prompts, There are 34 active compounds mapping 114 targets in Sophora japonica decoction; G enecards database prompts, A total of 858 targets are closely related to CRC, The two data sets map each other to obtain 114 intersection targets. Core components of Sophora flavescens decoction in treating CRC may be quercetin, kaempferol, luteolin, The core therapeutic targets may be PTGS2、PTGS1、HSP90AA1 and AR, CRC related pathways involve multiple molecular functions such as cell proliferation, apoptosis, cell signal transduction, metabolism, endocrine, tumor immunity, transcription and cell metabolism. Molecular docking results show that the binding ability of PTGS1、PTGS2、AR to core components is strong, The Vina value (binding energy) of the interaction between PTGS1 protein and core components is the best, -7.9kcal/mol . Conclusion: This study demonstrates the mechanism of multi-component, multi-target and multi-pathway action in the treatment of CRC, Can provide the idea for clarifying the specific mechanism of Huaijiao Diyu decoction in the treatment of CRC in the future.

show abstract

“…The days. The arthritis score was quantified based on swelling and redness (graded from 0-4 for each paw; 0: normal; 1: slight swelling and redness; 2: moderate swelling and redness; 3: severe swelling and redness in large joints and moderate swelling and redness in small joints; 4: most severe swelling and redness in large joints and severe swelling and redness in small joints ) [12].…”

Section: Methodsmentioning

confidence: 99%

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

li

¹

,

Yang

²

,

Qin

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice. Results: The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws was observed in type II collagen-induced arthritis (CIA) mice. Besides, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6C hi monocytes, decreased B cells and CD4 + T cells, were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significantly higher levels of serum IL-4 and IL-17 than those in CIA mice. Conclusions: Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of the immune response in mice with CIA.

show abstract

Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice

Cited by 11 publications

References 32 publications

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

Research on the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

Contact Info

Product

Resources

About