Protective Effects of Fucoidan, a P- and L-Selectin Inhibitor, in Murine Acute Pancreatitis

Carvalho, Ana Carla da Silva; Sousa, Rhamon B.; Franco, Álvaro Xavier; Costa, José Victor Gomes; Neves, Luara Manuela; Ribeiro, Ronaldo A.; Sutton, Robert; Criddle, David N.; Soares, Pedro Marcos Gomes; Souza, Michael

doi:10.1097/mpa.0b013e3182a63b9d

Cited by 44 publications

(25 citation statements)

References 37 publications

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“…The levels of cytokines and MPO were significantly reduced showing its pharmacological effect. The intervention attenuated histological pattern in both the models thus supporting the biochemical results (Carvalho et al , ). Hence, inhibition of P‐selectins may prove to be a novel approach to combat the inflammation associated with AP.…”

Section: Herbal Remedies Used For Treating Pancreatitissupporting

confidence: 84%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Herbal Remedies Used For Treating Pancreatitissupporting

confidence: 84%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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“…Not only did the oral formulations alleviate the macroscopic pathologies such as body weight and stool consistency, they also significantly reduced the underlying intestinal inflammation. Although previous reports have demonstrated anti-inflammatory activities of fucoidan and fucoidan-containing extracts in different experimental models in vitro and in vivo [18, 22, 31–36], this is the first report to demonstrate that dietary fucoidan extracts from Fucus vesiculosus are highly effective in ameliorating experimental colitis through a consistent downregulation of a significant number of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 72%

Fucoidan Extracts Ameliorate Acute Colitis

Lean

Eri

Fitton³

et al. 2015

PLoS ONE

104

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Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease, are an important cause of morbidity and impact significantly on quality of life. Overall, current treatments do not sustain a long-term clinical remission and are associated with adverse effects, which highlight the need for new treatment options. Fucoidans are complex sulphated, fucose-rich polysaccharides, found in edible brown algae and are described as having multiple bioactivities including potent anti-inflammatory effects. Therefore, the therapeutic potential of two different fucoidan preparations, fucoidan-polyphenol complex (Maritech Synergy) and depyrogenated fucoidan (DPF) was evaluated in the dextran sulphate sodium (DSS) mouse model of acute colitis. Mice were treated once daily over 7 days with fucoidans via oral (Synergy or DPF) or intraperitoneal administration (DPF). Signs and severity of colitis were monitored daily before colons and spleens were collected for macroscopic evaluation, cytokine measurements and histology. Orally administered Synergy and DPF, but not intraperitoneal DPF treatment, significantly ameliorated symptoms of colitis based on retention of body weight, as well as reduced diarrhoea and faecal blood loss, compared to the untreated colitis group. Colon and spleen weight in mice treated with oral fucoidan was also significantly lower, indicating reduced inflammation and oedema. Histological examination of untreated colitis mice confirmed a massive loss of crypt architecture and goblet cells, infiltration of immune cells and oedema, while all aspects of this pathology were alleviated by oral fucoidan. Importantly, in this model, the macroscopic changes induced by oral fucoidan correlated significantly with substantially decreased production of at least 15 pro-inflammatory cytokines by the colon tissue. Overall, oral fucoidan preparations significantly reduce the inflammatory pathology associated with DSS-induced colitis and could therefore represent a novel nutraceutical option for the management of IBD.

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“…However, we demonstrated that only fucoidans derived from U. pinnatifida and M. pyrifera could inhibit neutrophil apoptosis at low concentration. The most plausible hypothesis to explain the specific inhibitory effect of fucoidans on neutrophil apoptosis could be their ability to react with L- and P-selectins on neutrophils [ 19 ]. It is well-established that L-selectin is efficiently shed from the surface of neutrophils and down-regulation of L-selectin is induced during programmed neutrophil apoptosis [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

Zhang

Oda

Yu³

et al. 2015

Marine Drugs

164

130

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Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, such as promoting activation of dendritic cells (DCs), natural killer (NK) cells and T cells, and enhancing anti-viral and anti-tumor responses. However, the immune-modulatory effect of fucoidan from different seaweed extracts has not been thoroughly analyzed and compared. We analyzed fucoidans obtained from Ascophyllum nodosum (A. nodosum), Macrocystis pyrifera (M. pyrifera), Undaria pinnatifida (U. pinnatifida) and Fucus vesiculosus (F. vesiculosus) for their effect on the apoptosis of human neutrophils, activation of mouse NK cells, maturation of spleen DCs, proliferation and activation of T cells, and the adjuvant effect in vivo. Fucoidans from M. pyrifera and U. pinnatifida strongly delayed human neutrophil apoptosis at low concentration, whereas fucoidans from A. nodosum and F. vesiculosus delayed human neutrophil apoptosis at higher concentration. Moreover, fucoidan from M. pyrifera promoted NK cell activation and cytotoxic activity against YAC-1 cells. In addition, M. pyrifera fucoidan induced the strongest activation of spleen DCs and T cells and ovalbumin (OVA) specific immune responses compared to other fucoidans. These data suggest that fucoidan from M. pyrifera can be potentially useful as a therapeutic agent for infectious diseases, cancer and an effective adjuvant for vaccine.

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Protective Effects of Fucoidan, a P- and L-Selectin Inhibitor, in Murine Acute Pancreatitis

Abstract: Fucoidan reduced the severity of acute pancreatitis in mice by decreasing neutrophil infiltration and systemic inflammation, suggesting that modulation of selectins may constitute a promising therapeutic approach.

Cited by 44 publications

References 37 publications

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

Fucoidan Extracts Ameliorate Acute Colitis

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

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