Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat model

Kaya, Serkan; Kaya, Sinem; Polat, Elif; Gürboğa, Zeynep Fidanol; Duran, Yasin; Polat, Fatin Rüştü; Okuyan, Hamza Malik; Karaboğa, İhsan

doi:10.5606/tgkdc.dergisi.2020.18816

Cited by 7 publications

(6 citation statements)

References 42 publications

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“…Free radicals are molecules that are extremely reactive and have the potential to induce the injury into the cells and tissues in the body 4,5 . This can lead to inflammation, which is a response by the body's immune system to try to remove the damaging agents and repair the damaged tissue 5,34 .…”

Section: Discussionmentioning

confidence: 99%

“…ALI is a clinical condition that is characterized by inflammation in the lung tissues and it is consider as the common cause of lung dysfunction. It is identified by inflammation and the build‐up of fluids in the lungs, which can hinder the efficient transfer of oxygen from the air to the blood 3–5 . This alteration can cause the difficulty in the breathing and also exhibit the low oxygen level in the blood (hypoxemia).…”

Section: Introductionmentioning

confidence: 99%

“…It is identified by inflammation and the build-up of fluids in the lungs, which can hinder the efficient transfer of oxygen from the air to the blood. [3][4][5] This alteration can cause the difficulty in the breathing and also exhibit the low oxygen level in the blood (hypoxemia). Severe hypoxemia, which refers to low levels of oxygen in the blood, is a prevalent complication of ALI.…”

Section: Introductionmentioning

confidence: 99%

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Gossypin exert lipopolysaccharide induced lung inflammation via alteration of Nrf2/HO‐1 and NF‐κB signaling pathway

Huang

Wang²,

Hussain

et al. 2023

Environmental Toxicology

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Acute Lung Injury (ALI) is a critical medical condition that induces the injury into the lung tissue, resulting in decreased the oxygen levels in the circulation and finally causes the respiratory failure. In this study, we try to made effort for scrutinized the preventive effect of gossypin against lipopolysaccharide (LPS) induced lung inflammation and explore the underlying mechanism. LPS (7.5 mg/kg) was used for induction the lung inflammation in the rats and rats were received the oral administration of gossypin (5, 10 and 15 mg/kg). The wet to dry weight lung ratio and lung index were estimated. The bronchoalveolar lavage fluid (BALF) were collected to determination the inflammatory cells, total protein, macrophages and neutrophils. ELISA kits were used for the estimation of antioxidant, inflammatory cytokines, inflammatory parameters, nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) parameters. Finally, we used the lung tissue for scrutinize the alteration in the lung histopathology. Gossypin treatment significantly (p < .001) reduced the W/D ratio of lung tissue and lung index. Gossypin significantly (p < .001) decreased the total cells, neutrophils, macrophages and total protein in BALF. It is also altered the level of inflammatory cytokines, antioxidant and inflammatory parameters, respectively. Gossypin improved the level of Nrf2 and HO-1 at dose dependent manner. Gossypin treatment remarkably enhance the ALI severity via balancing the structural integrity of lung tissue, decrease the thickness of the alveolar wall, decline the pulmonary interstitial edema, and number of inflammatory cells in the lung tissue. Gossypin is a

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gossypin exert lipopolysaccharide induced lung inflammation via alteration of Nrf2/HO‐1 and NF‐κB signaling pathway

Huang

Wang²,

Hussain

et al. 2023

Environmental Toxicology

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“…Yeh et al, 2007). Its aglycone part, namely hesperitin, is reported to inhibit TNF‐α, IL‐1β, and IL‐6 significantly by hindering multiple pathways like JNK, NF‐κB, and MAPK based on the in vitro (Choi & Lee, 2010; Ren et al, 2016) and in vivo investigations (Kaya, 2020; J. Ye et al, 2019). In a clinical study involving human adults, hesperidin exhibited a significant reduction of IL‐6 level at an oral dose of 160 mg/day (Buscemi et al, 2012; Pla‐Pagà et al, 2019).…”

Section: Potential Of Flavonoids To Be Phytotherapeutics For Sars‐cov‐2 Infectionmentioning

confidence: 99%

“…On the other hand, EGCG suppresses the secretion of IL-6, IL-1β, and TNF-ɑ in fluoride (Shanmugam et al, 2016) and sea aspiration (Liu, Dong, et al, 2014 Overall, it could be summarized that EGCG could be a potential candidate to combat SARS-Cov-2. Its aglycone part, namely hesperitin, is reported to inhibit TNF-α, IL-1β, and IL-6 significantly by hindering multiple pathways like JNK, NF-κB, and MAPK based on the in vitro (Choi & Lee, 2010;Ren et al, 2016) and in vivo investigations (Kaya, 2020;J. Ye et al, 2019).…”

Section: Egcgmentioning

confidence: 99%

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2

Gour

Manhas

Bag

et al. 2021

Phytotherapy Research

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Emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection, COVID‐19, has become the global panic since December 2019, which urges the global healthcare professionals to identify novel therapeutics to counteract this pandemic. So far, there is no approved treatment available to control this public health issue; however, a few antiviral agents and repurposed drugs support the patients under medical supervision by compromising their adverse effects, especially in emergency conditions. Only a few vaccines have been approved to date. In this context, several plant natural products‐based research studies are evidenced to play a crucial role in immunomodulation that can prevent the chances of infection as well as combat the cytokine release storm (CRS) generated during COVID‐19 infection. In this present review, we have focused on flavonoids, especially epicatechin, epigallocatechin gallate, hesperidin, naringenin, quercetin, rutin, luteolin, baicalin, diosmin, ge nistein, biochanin A, and silymarin, which can counteract the virus‐mediated elevated levels of inflammatory cytokines leading to multiple organ failure. In addition, a comprehensive discussion on available in silico, in vitro, and in vivo findings with critical analysis has also been evaluated, which might pave the way for further development of phytotherapeutics to identify the potential lead candidatetoward effective and safe management of the SARS‐CoV‐2 disease.

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Protective effect of olopatadine hydrochloride against LPS-induced acute lung injury: via targeting NF-κB signaling pathway

Kaur,

Rana,

Matta

et al. 2023

Inflammopharmacol

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Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat model

Cited by 7 publications

References 42 publications

Gossypin exert lipopolysaccharide induced lung inflammation via alteration of Nrf2/HO‐1 and NF‐κB signaling pathway

Gossypin exert lipopolysaccharide induced lung inflammation via alteration of Nrf2/HO‐1 and NF‐κB signaling pathway

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2

Protective effect of olopatadine hydrochloride against LPS-induced acute lung injury: via targeting NF-κB signaling pathway

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