Protective effects of Hydrocotyle umbellata var. bonariensis Lam. (Araliaceae) on memory in sleep-impaired female mice

Barbosa, C.C.; Rodrigues, Thamyres Cunha; Ataídes, C.F.S.; Santos, Mateus Pereira dos; Ghedini, Paulo César; Junior, Walter Dias; Andersen, Mônica Levy; Mazaro-Costa, Renata

doi:10.1016/j.jep.2019.112183

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Cardiac arrhythmias induced by modulation of the QT interval via certain drugs including antiarrhythmics, antibiotics, antidepressants and neuroleptics, is a relatively frequent side effect of great clinical importance. 4 Hydrocotyle bonariensis, like most medicinal plants used in sub-Saharan Africa in the traditional management of cardiovascular disease, 5 , 6 has not been yet the subject of scientific studies evaluating its effect on the QT interval.…”

Section: Introductionmentioning

confidence: 99%

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy

Kaboua

Mouzou²,

Pakoussi³

et al. 2022

Journal of Traditional and Complementary Medicine

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Section: Introductionmentioning

confidence: 99%

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy

Kaboua

Mouzou²,

Pakoussi³

et al. 2022

Journal of Traditional and Complementary Medicine

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“…bonariensis (Lam.) Spreng], popularly known as ‘acariçoba’, have been used in traditional medicine delaying effects of aging, in the treatment of stress and neurological diseases [11,12] . Phytochemically, this species produce alkaloids, lignoids, terpenoids, poliacetylenes, and flavonoids, [13–22] with anxiolytic, allelopathic, antioxidant, and antimicrobial activities [12,23–25] .…”

Section: Introductionmentioning

confidence: 99%

“…Spreng], popularly known as 'acariçoba', have been used in traditional medicine delaying effects of aging, in the treatment of stress and neurological diseases. [11,12] Phytochemically, this species produce alkaloids, lignoids, terpenoids, poliacetylenes, and flavonoids, [13 -22] with anxiolytic, allelopathic, antioxidant, and antimicrobial activities. [12,[23][24][25] As part of our continuous studies aiming the discovery on new antitrypanosomal natural products, the crude hexane extract from H. bonariensis demonstrated activity against the trypomastigote forms of T. cruzi and was subjected to bioactivity-guided fractionation procedures to afford two chemically related dibenzylbutyrolactone lignans -hinokinin (1) and hibalactone (2).…”

Section: Introductionmentioning

confidence: 99%

Simplified Derivatives of Dibenzylbutyrolactone Lignans from Hydrocotyle bonariensis as Antitrypanosomal Candidates

Souza

Costa-Silva

Morais

et al. 2021

Chemistry & Biodiversity

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The search for the pharmacophore of a bioactive compound, crucial for drug discovery studies, involves the adequate arrangement of different atoms in the molecule. As part of a continuous work aiming discovery of new drug candidates against the protozoan parasite Trypanosoma cruzi, the hexane extract of Hydrocotyle bonariensis was subjected to a bioactivity‐guided fractionation to afford two chemically related dibenzylbutyrolactone lignans – hinokinin (1) and hibalactone (2). Compounds 1 and 2 showed activity against trypomastigote with EC50 values of 17.0 and 69.4 μM, respectively. Compound 1 was also active against the clinically relevant form of the parasite, amastigotes, displaying an EC50 value of 34.4 μM. The structure‐activity relationship (SAR) indicated that the absence of the double bond at C‐7 is a crucial feature for the increment of the antiparasitic activity. The lethal action of the most potent compound 1 was investigated in the trypomastigotes. The fluorescent‐based assay with SYTOX Green demonstrated a significant alteration of the plasma membrane permeability of the parasite. Additionally, compound 1 demonstrated no significant hemolytic activity in mice erythrocytes at 200 μM. To search the pharmacophore, three different simplified compounds – 3,4‐methylenedioxydihydrocinnamic acid (3), 3,4‐methylenedioxydihydrocinnamic alcohol (4) and 3,4‐methylenedioxycinnamic acid (5) – were prepared and tested against T. cruzi. These derivatives displayed EC50 values of 37.2 (3), 25.8 (4) and 73.5 (5) μM against trypomastigotes, and 41.3 (3) and 48.2 (4) μM against amastigotes, whereas compound 5 was inactive. Except for compound 2, which resulted in a CC50 value of 114.5 μM, all compounds showed no mammalian cytotoxicity at 200 μM. An in silico ADMET study was performed and predicted values demonstrated an acceptable drug‐likeness profile for compounds 1–5. Despite the minor reduction in the potency, the simplified derivatives retained the antitrypanosomal activity against the intracellular amastigotes, even with 95 % reduction of their molecular weight. Additionally, in silico studies suggested them as more soluble compounds, making these simplified structures promising scaffolds for optimization studies in Chagas disease.

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REM sleep deprivation induced by the modified multi-platform method has detrimental effects on memory: A systematic review and meta-analysis

Diao,

Li,

Sun

et al. 2023

Behavioural Brain Research

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Protective effects of Hydrocotyle umbellata var. bonariensis Lam. (Araliaceae) on memory in sleep-impaired female mice

Cited by 6 publications

References 36 publications

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy

Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy

Simplified Derivatives of Dibenzylbutyrolactone Lignans from Hydrocotyle bonariensis as Antitrypanosomal Candidates

REM sleep deprivation induced by the modified multi-platform method has detrimental effects on memory: A systematic review and meta-analysis

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