Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis

Askari, Hasan; Seifi, Behjat; Kadkhodaee, Mehri; Sanadgol, Nima; Elshiekh, Mohammed; Ranjbaran, Mina; Ahghari, Parisa

doi:10.17179/excli2017-711

Cited by 15 publications

(11 citation statements)

References 37 publications

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“…Intending to utilize the antioxidative impact, several groups have investigated the potential therapeutic benefits of hydrogen sulfide or supersulfides for kidney diseases [ 32 , 33 ]. Askari et al demonstrated that NaHS, as a hydrogen sulfide donor, attenuated kidney dysfunctions in 5/6-nephrectomy CKD model mice by modulating redox balance [ 34 ]. Cao et al have shown the therapeutic effect of Na 2 S 4 on cisplatin-induced acute kidney injury [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways

Ikeda-Imafuku,

Fukuta,

Tuan Giam Chuang

et al. 2024

Pharmaceuticals

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Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI). Antioxidants are, therefore, thought to aid in the recovery of illnesses linked to oxidative stress. Supersulfide species have been shown to have substantial antioxidative activity; however, due to their limited bioavailability, few supersulfide donors have had their actions evaluated in vivo. In this study, human serum albumin (HSA) and N-acetyl-L-cysteine polysulfides (NACSn), which have polysulfides in an oxidized form, were conjugated to create a supersulfide donor. HSA is chosen to be a carrier of NACSn because of its extended blood circulation and high level of biocompatibility. In contrast to a supersulfide donor containing reduced polysulfide in HSA, the NACSn-conjugated HSAs exhibited stronger antioxidant activity than HSA and free NACSn without being uptaken by the cells in vitro. The supersulfide donor reduced the levels of blood urea nitrogen and serum creatinine significantly in a mouse model of rhabdomyolysis-induced AKI. Supersulfide donors significantly reduced the expression of oxidative stress markers in the kidney. These results indicate that the developed supersulfide donor has the therapeutic effect on rhabdomyolysis-induced AKI.

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Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways

Ikeda-Imafuku,

Fukuta,

Tuan Giam Chuang

et al. 2024

Pharmaceuticals

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“…Treatment with NaHS reduced BP and increased creatinine clearance. NaHS has also been shown to reduce malondialdehyde levels and increase superoxide dismutase activity [ 77 ].…”

Section: Involvement Of H 2 S In Chronic Kidney Di...mentioning

confidence: 99%

“…One study has shown that H 2 S can effectively inhibit cleaved caspase–3 activity and thus reduce the extent of renal apoptosis [ 77 ]. Therefore, we predict that a reduction in cleaved caspase–3 activity may be a key step for H 2 S to play an antiapoptotic role, but a large number of experiments are still needed to verify this hypothesis [ 81 ].…”

Section: Involvement Of H 2 S In Chronic Kidney Di...mentioning

confidence: 99%

The roles of hydrogen sulfide in renal physiology and disease states

Feng

et al. 2022

Renal Failure

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Hydrogen sulfide (H 2 S), an endogenous gaseous signaling transmitter, has gained recognition for its physiological effects. In this review, we aim to summarize and discuss existing studies about the roles of H 2 S in renal functions and renal disease as well as the underlying mechanisms. H 2 S is mainly produced by four pathways, and the kidneys are major H 2 S–producing organs. Previous studies have shown that H 2 S can impact multiple signaling pathways via sulfhydration. In renal physiology, H 2 S promotes kidney excretion, regulates renin release and increases ATP production as a sensor for oxygen. H 2 S is also involved in the development of kidney disease. H 2 S has been implicated in renal ischemia/reperfusion and cisplatin–and sepsis–induced kidney disease. In chronic kidney diseases, especially diabetic nephropathy, hypertensive nephropathy and obstructive kidney disease, H 2 S attenuates disease progression by regulating oxidative stress, inflammation and the renin–angiotensin–aldosterone system. Despite accumulating evidence from experimental studies suggesting the potential roles of H 2 S donors in the treatment of kidney disease, these results need further clinical translation. Therefore, expanding the understanding of H 2 S can not only promote our further understanding of renal physiology but also lay a foundation for transforming H 2 S into a target for specific kidney diseases.

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“…Deficiency of H 2 S and its anti-oxidant, anti-inflammatory, and cytoprotective properties may contribute to the progression of CKD and mortality [ 2 ]. H 2 S biosynthesis inhibitors significantly worsen renal parameters [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes

Farahat

Kherkheulidze

Nopp

et al. 2023

Toxins

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Impaired polymorphonuclear leukocyte (PMNL) functions contribute to increased infections and cardiovascular diseases in chronic kidney disease (CKD). Uremic toxins reduce hydrogen sulfide (H2S) levels and the anti-oxidant and anti-inflammatory effects of H2S. Its biosynthesis occurs as a side process of transsulfuration and in the disposal of adenosylhomocysteine, a transmethylation inhibitor and proposed uremic toxin. PMNL chemotaxis was measured by the under-agarose method, phagocytosis, and oxidative burst by flow cytometry in whole blood and apoptosis by determining DNA content by flow cytometry and morphological features by fluorescence microscopy. Sodium hydrogen sulfide (NaHS), diallyl trisulphide (DATS) and diallyl disulphide (DADS), cysteine, and GYY4137 were used as H2S-producing substances. Increased H2S concentrations did not affect chemotaxis and phagocytosis. NaHS primed PMNL oxidative burst activated by phorbol 12-myristate 13-acetate (PMA) or E. coli. Both DATS and cysteine significantly decreased E. coli-activated oxidative burst but had no effect on PMA stimulation. While NaHS, DADS, and cysteine attenuated PMNL apoptosis, GYY4137 decreased their viability. Experiments with signal transduction inhibitors suggest that the intrinsic apoptosis pathway is mainly involved in GYY4137-induced PMNL apoptosis and that GYY4137 and cysteine target signaling downstream of phosphoinositide 3-kinase.

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Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis

Cited by 15 publications

References 37 publications

Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways

Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways

The roles of hydrogen sulfide in renal physiology and disease states

Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes

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