Protective effects of Aloe sterols against <scp>UVB</scp>‐induced photoaging in hairless mice

Misawa, Eriko; Tanaka, Miyuki; Stenmark-Askmalm, Marie; Nabeshima, Kazumi; Yao, Ru; Yamauchi, Kouji; Abe, Fumiaki; Yamamoto, Yuki; Furukawa, Fukumi

doi:10.1111/phpp.12286

Cited by 39 publications

(26 citation statements)

References 39 publications

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“…3). A fibroblast collagenase, MMP-13, is the key enzyme responsible for breaking down dermal components (31,32). Once the MMP-13 activation initiates degradation of fibrillary type I and III collagen, further processing is performed by MMP-3 and MMP-9 (23).…”

Section: Discussionmentioning

confidence: 99%

Orally Administered Polysaccharide Derived from Blackcurrants (Ribes nigrum L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

Ashigai

Komano

Wang

et al. 2018

J Nutr Sci Vitaminol

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Blackcurrants (Ribes nigrum L.) have various benefits for human health. In particular, a polysaccharide derived from blackcurrant was found to be an immunostimulating food ingredient in a mouse model. We named a polysaccharide derived from blackcurrant cassis polysaccharide (CAPS). In a previous clinical study, we reported that CAPS affects skin dehydration, demonstrating its effectiveness against skin inflammation was related to atopic dermatitis; skin inflammation caused skin dehydration. However, there are no studies regarding CAPS effectiveness against skin dehydration. The current study aimed to investigate CAPS effectiveness against skin dehydration. We further demonstrate the effect of oral administration of CAPS on skin dehydration caused by ultraviolet (UV) irradiation-induced inflammation in mice. We found that CAPS administration suppresses skin dehydration caused by UV irradiation. We also found that CAPS decreases interleukin-6 and matrix metalloproteinase transcription levels in the mouse skin. These results show that CAPS improves skin hydration in UV-irradiated mice.

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Section: Discussionmentioning

confidence: 99%

Orally Administered Polysaccharide Derived from Blackcurrants (Ribes nigrum L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

Ashigai

Komano

Wang

et al. 2018

J Nutr Sci Vitaminol

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“…The bioactive components in A. vera have been reported to have antifungal, antiseptic, antiviral, antibacterial, anti-inflammatory, antioxidant, immuno-modulatory and wound healing properties 61,62 . Several studies also demonstrated beneficial effects of A. vera on UVB-induced damage [63][64][65] .…”

Section: Aloe Veramentioning

confidence: 96%

Ultraviolet A protective potential of plant extracts and phytochemicals

Škařupová

Vostalová

Svobodová

2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

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“…They have also been found to decrease the expression of MMP-2 and MMP-9, protecting collagen and the ECM from degradation, in UVB-irradiated hairless mice [ 47 ]. In addition, studies have showed that oral Aloe sterol may encourage the production of hyaluronic acid in human dermal fibroblasts [ 49 ]. Further studies are needed to determine the role of oral Aloe sterols and optimal daily allowance while accessing for supplementation health risks.…”

Section: Potential Future Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals: A Review

Souyoul

Saussy

Lupo

2018

Dermatol Ther (Heidelb)

116

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Skin aging is continuously influenced by various internal and external factors such as the biologic progression of cells, ultraviolet (UV) radiation, tobacco, nutritional deficiencies, and hormonal imbalances that lead to the degradation of skin cells. Through the degradation of skin cells, free radicals and inflammation weaken repair mechanisms and result in collagen and elastic fiber breakdown. The appearance of aging skin is highlighted by skin roughness, wrinkling, pigmentation change, telangiectasias, loss of elasticity, and decreased firmness, all of which are accelerated by these internal and external factors. Throughout the years, nutraceuticals have been studied to delay and fight against these internal and external factors, many of which are found in foods and byproducts consumed naturally. The aim of this review is to aid dermatologists in understanding the mechanism of action of popular nutraceuticals and their possible efficacy in antiaging and skin health.

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Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice

Abstract: The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin, and our results suggest that Aloe sterols may prevent skin photoaging through the anti-inflammation and MMP regulation.

Cited by 39 publications

References 39 publications

Orally Administered Polysaccharide Derived from Blackcurrants (<i>Ribes nigrum</i> L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

Orally Administered Polysaccharide Derived from Blackcurrants (<i>Ribes nigrum</i> L.) Improves Skin Hydration in Ultraviolet-Irradiated Hairless Mice

Ultraviolet A protective potential of plant extracts and phytochemicals

Nutraceuticals: A Review

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