Protective Effects ofBorago officinalisExtract on Amyloidβ-Peptide(25–35)-Induced Memory Impairment in Male Rats: A Behavioral Study

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the protective effects of Borago officinalis (borage) extract on Amyloid β (Aβ)-Induced memory impairment. Wistar male rats received intrahippocampal (IHP) injection of the Aβ(25–35) and borage extract throughout gestation (100 mg/kg). Learning and memory functions in the rats were examined by the passive avoidance and the Morris water maze (MWM) tasks. Finally, the antioxidant capacity of hippocampus was measured using ferric ion reducing antioxidant power (FRAP) assay. The results showed that Aβ(25–35) impaired step-through latency and time in dark compartment in passive avoidance task. In the MWM, Aβ(25–35) significantly increased escape latency and traveled distance. Borage administration attenuated the Aβ-induced memory impairment in both the passive avoidance and the MWM tasks. Aβ induced a remarkable decrease in antioxidant power (FRAP value) of hippocampus and borage prevented the decrease of the hippocampal antioxidant status. This data suggests that borage could improve the learning impairment and oxidative damage in the hippocampal tissue following Aβ treatment and that borage consumption may lead to an improvement of AD-induced cognitive dysfunction.

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

“…Many species of Boraginaceae family are grown in Iran and some of them are used in ethnomedicine [4] . However, there were no studies about their antiglycation properties and therefore, in the present study, we investigated the in vitro effects of aqueous and hydroethanol extracts of E. italicum, A. arvensis and T. incanum on albumin, hemoglobin, and crystalline glycation reactions.…”

“…Some of these plants grow in Iran and used widely in Iran's folk medicine [2,3] . It has been reported that Borage (Borago officinalis L.) was useful for its antipyretic, antihypertensive, antispasmodic, aphrodisiac and diuretic properties [4,5] . Previous findings showed that some species of Boraginaceae were used for the treatment of hemorrhoids [6] .…”

Estudos Pré-Clínicos E Clínicos De Espécies Vegetais Selecionadas De Países Pertencentes Ao Mercosul E Aspectos Toxicológicos

“…Estudos fitoquímicos mostraram que B. officinalis é composta por taninos, reninas, ácido ascórbico, beta-caroteno, niacina, riboflavina, ácido rosmarínico e flavonoides. Porém, é considerada como fonte de áci-do gama-linolênico, o qual possui efeitos benéficos no envelhecimento do cérebro, melhorando também a memória (37 É utilizada para regular o metabolismo e o sistema hormonal, indicada para amenizar sintomas da menopausa, como as ondas de calor. Ainda, é usada para aliviar e curar resfriados, bronquite e infecções respiratórias, por ter ação anti-inflamatória (36).…”

Effects of hydroalcoholic extract of <i>Borago officinalis</i> on naloxone-precipitated withdrawal syndrome in morphine-dependent mice

“…The solution was kept at room temperature for one week. Then, the extract filtered and the filtered solution was left at 37°C temperature for evaporation of alcohol and water in it (Ghahremanitamadon et al, 2014).…”