Protective Effects of Lepidium meyenii (Maca) Aqueous Extract and Lycopene on Testosterone Propionate-Induced Prostatic Hyperplasia in Mice

Abstract

The inhibitory effect of maca extractant, lycopene, and their combination was evaluated in benign prostatic hyperplasia (BPH) mice induced by testosterone propionate. Mice were divided into a saline group, solvent control group and testosterone propionate-induced BPH mice [BPH model group, solvent BPH model group, benzyl glucosinolate group (1.44 mg/kg), maca group (60 mg/kg), lycopene treated (15, 5, and 2.5 mg/kg), maca (30 mg/kg) combine lycopene treated (7.5, 2.5, and 1.25 mg/kg), and finasteride treated]. Benzyl glucosinolate was used in order to evaluate its pharmacological activity on BPH to find out whether it is the major active component of maca aqueous extract. Finasteride was used as positive control. The compounds were administered once for 30 successive days. Compared with solvent BPH model group, BPH mice fed with maca (30 mg/kg) and lycopene (7.5 mg/kg) combination exhibited significant reductions in the prostatic index, prostatic acid phospatase, estradiol, testosterone, and dihydrotestosterone levels in serum. They also had similar histological compared with those aspects observed in the mice in the solvent control group. The results indicated that combination of maca and lycopene synergistically inhibits BPH in mice. Copyright © 2017 John Wiley & Sons, Ltd.

Testosterone inhibits aneurysm formation and vascular inflammation in male mice

“…Control mice were administered the same volume of safflower seed oil (Sigma-Aldrich) at the same time. The doses of testosterone administration in this study were based on Zhao et al (2014), Ren et al (2017), andZou et al (2017) and the results of our preliminary experiment in the aorta.…”

Therapeutic effect of iodised serum milk protein, lycopene and their combination on benign prostatic hyperplasia induced in rats

“…This is consistent with results of other works in which lycopene was used in several experimental BPH models. It was previously shown that lycopene isomers and lycopene in combination with Lepidium meyenii extract exert inhibitory effect on propionate‐induced BPH in mice (Zou et al., 2014, 2017). In addition, lycopene is effective in chemically induced prostatitis model through reduction in oxidative stress and inflammation pathways (Zhao et al., 2020).…”

“…A large group of natural compounds, including carotenoids, are used for BPH treatment or prophylaxis since they are quite effective and have low toxicity (Cicero et al., 2019). Among them, lycopene is one of the most promising agents as it is able to inhibit BPH both in the experiments and in patients (Dulińska‐Litewka et al., 2021; Zou et al., 2014, 2017). Still, its interaction with other supplementations which also have an inhibitory effect on BPH is poorly studied.…”

A Randomized, Double-Blind, Placebo-Controlled Study of a Nutraceutical Supplement for Promoting Hair Growth in Perimenopausal, Menopausal, and Postmenopausal Women With Thinning Hair

“…28 It also has adaptogenic effects, reducing stress-induced corticosterone levels, 29 and targets DHT. 30 Astaxanthin is an antioxidant 600-times more potent than vitamin C. It possesses anti-inflammatory and antioxidant properties, improving oxidative status overall and in aging skin. 31,32 In the current study, the daily use of this blend of nutraceutical-grade extracts significantly increased the number of terminal and vellus hairs in perimenopausal, menopausal, and post-menopausal women.…”